116 lines
4.8 KiB
Plaintext
116 lines
4.8 KiB
Plaintext
Various paragraphs from the PDR regarding various brands of Yohimbine:
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Yohimbine is an indolealkylamine alkaloid [this is the same group that
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includes Psilocybin] with chemical similarity to
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reserpine. It is the principal alkaloid of the bark of the West African
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'Corynanthe yohimbe' tree and is aslo found in Rauwolfia Serpentina.
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"... causes erectile stimulation without increasing sexual desire."
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OVERDOSAGE: Daily doses of 20-30mg may produce increases in heart rate and
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blood pressure, piloerection [hair stands on end/goosebumps] and rhinorrhea
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[runny nose]. More severe symptoms may include paresthesias [local numbness],
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incoordination, tremulousness and a DISSOCIATIVE STATE [spaced-out dreamlike
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feeling of unreality] with higher doses.
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WARNING: Generally this drug is not proposed for use in females and certainly
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must not be used during pregnancy. Neither is this drug proposed for use in
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pediatric, geriatric, or cardio-renal patients with gastric or duodenal ulcer
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history. Nor should it be used in conjunction with mood altering drugs such
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as antidepressants, or in psychiatric patients in general.
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ADVERSE REACTIONS: Yohimbine readily penetrates the CNS and produces a
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complex pattern of responses at lower doses than required to produce
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alpha-adrenergic blockade. These include antiduresis [reduced urination] a
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general picture of central excitation including elevation of blood pressure
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and heart rate increased motor activity, irritability and tremor. Sweating
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nausea and vomiting are common after parenteral [not by digestion]
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administration of the drug. Also dizzyness, headache, skin flushing reported
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when used orally.
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----
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Brand Name Mfr. Dose Drug
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---------- -------------------------- ---- -----------------------
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APHRODYNE Star 5.4mg Yohimbine hydrochloride
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ACTIBINE Consolidated Midland 5mg Yohimbine hydrochloride
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YOHIMEX Kramer Yohimbine hydrochloride
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YOCON Palisades Pharmaceuticals 5.4mg Yohimbine
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"Yohimbine blocks presynaptic alpha-2-adrenergic receptors. It's action on
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peripheral blood vessels resembles that of reserpine, though it is weaker and
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of short duration. Yohimbine's peripheral autonomic nervous system effect is
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to increase parasympathetic (cholinergic) and decrease sympathetic
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(adrenergic) activity.
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...
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Yohimbine exerts a stimulating action on the mood and may increase anxiety.
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Such actions have not been adequately studied or related to dosage. Although
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they appear to require hight doses of the drug. Yohimbine has a mild
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anti-diuretic action, probably via stimulation of hypothalamic centers and
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release of posterior pituitary hormone.
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Reportedly, Yohimbine exerts no significant influence on cardiac stimulation
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and other effects mediated by beta-adrenergic receptors, its effect on blood
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pressure, if any, would be to lower it; however, no adequate studies are at
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hand to quantitate this effect in terms of Yohimbine dosage.
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YOCON is indicated as a sympathicolytic and mydriatic. It may have activity
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as an aphrodisiac.
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Yohimbine "Alpha-2-Adrenergic blocker"
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( From Corynanthe yohimbe & Rauwolfia serpentina )
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/\ /\
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// \ _____ / \
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\\ / \ / \ /\
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\/ \N/ \/ \
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H | |
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\ /\
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\/ \
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/\ /
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H3COOC \/
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OH
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Psychoactive Plants pharmacologically and/or botanically related to Yohimbe:
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Rubiaceae [plant family]
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Corynanthe yohimbe (yohimbine)
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Caffea arabica (caffeine)
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Psychotria viridis (DMT/other indolealkylamines)
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Chinchona officinalis (Quinine Bark - antimalarial)
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(wild:S.America. cultiv:Java)
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Apocynaceae
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Rauwolfia serpentina
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Rauwolfia canescens (alpha-yohimbine)
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Aspidosperma quebracho blanco ("White Quebracho") (Quebrachamine)
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Anacardiaceae
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Loxoptrygium lorentzii ("Quebracho Colorado" for tanning leather)
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============================
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Medical Dictionary (Crown books $28)
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used in Southern Cameroon
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yohimbine same as quebrachine
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used as aphrodisiac, and to treat arteriosclerosis and angina pectoris
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==============================
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Merck Index 11th ed:
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--
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Raubasine (delta-yohimbine, tetrahydroserpentine, ajmalicine, Circolene
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Hydrosarpan, Isoarteril, Lamuran)
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From yohimbe & rauwolfia
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Antihypertensive, Anti-ischemic (cerebral & peripheral)
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--
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Other Yohimbe isomers etc:
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Pseudoyohimbine (from yohimbe)
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allo-yohimbine (alloyohimbine, dihydroyohimbine)
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alpha-yohimbine (from Rauwolfia canescens)
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(corynanthine,isoyohimbine,mesoyohimbine,rauwolscine)
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