116 lines
4.8 KiB
Plaintext
116 lines
4.8 KiB
Plaintext
|
Various paragraphs from the PDR regarding various brands of Yohimbine:
|
|||
|
|
---------------------------------------------------------------------
|
|||
|
|
|
|||
|
|
Yohimbine is an indolealkylamine alkaloid [this is the same group that
|
|||
|
|
includes Psilocybin] with chemical similarity to
|
|||
|
|
reserpine. It is the principal alkaloid of the bark of the West African
|
|||
|
|
'Corynanthe yohimbe' tree and is aslo found in Rauwolfia Serpentina.
|
|||
|
|
|
|||
|
|
"... causes erectile stimulation without increasing sexual desire."
|
|||
|
|
|
|||
|
|
OVERDOSAGE: Daily doses of 20-30mg may produce increases in heart rate and
|
|||
|
|
blood pressure, piloerection [hair stands on end/goosebumps] and rhinorrhea
|
|||
|
|
[runny nose]. More severe symptoms may include paresthesias [local numbness],
|
|||
|
|
incoordination, tremulousness and a DISSOCIATIVE STATE [spaced-out dreamlike
|
|||
|
|
feeling of unreality] with higher doses.
|
|||
|
|
|
|||
|
|
WARNING: Generally this drug is not proposed for use in females and certainly
|
|||
|
|
must not be used during pregnancy. Neither is this drug proposed for use in
|
|||
|
|
pediatric, geriatric, or cardio-renal patients with gastric or duodenal ulcer
|
|||
|
|
history. Nor should it be used in conjunction with mood altering drugs such
|
|||
|
|
as antidepressants, or in psychiatric patients in general.
|
|||
|
|
|
|||
|
|
ADVERSE REACTIONS: Yohimbine readily penetrates the CNS and produces a
|
|||
|
|
complex pattern of responses at lower doses than required to produce
|
|||
|
|
alpha-adrenergic blockade. These include antiduresis [reduced urination] a
|
|||
|
|
general picture of central excitation including elevation of blood pressure
|
|||
|
|
and heart rate increased motor activity, irritability and tremor. Sweating
|
|||
|
|
nausea and vomiting are common after parenteral [not by digestion]
|
|||
|
|
administration of the drug. Also dizzyness, headache, skin flushing reported
|
|||
|
|
when used orally.
|
|||
|
|
|
|||
|
|
----
|
|||
|
|
Brand Name Mfr. Dose Drug
|
|||
|
|
---------- -------------------------- ---- -----------------------
|
|||
|
|
APHRODYNE Star 5.4mg Yohimbine hydrochloride
|
|||
|
|
ACTIBINE Consolidated Midland 5mg Yohimbine hydrochloride
|
|||
|
|
YOHIMEX Kramer Yohimbine hydrochloride
|
|||
|
|
YOCON Palisades Pharmaceuticals 5.4mg Yohimbine
|
|||
|
|
|
|||
|
|
"Yohimbine blocks presynaptic alpha-2-adrenergic receptors. It's action on
|
|||
|
|
peripheral blood vessels resembles that of reserpine, though it is weaker and
|
|||
|
|
of short duration. Yohimbine's peripheral autonomic nervous system effect is
|
|||
|
|
to increase parasympathetic (cholinergic) and decrease sympathetic
|
|||
|
|
(adrenergic) activity.
|
|||
|
|
|
|||
|
|
...
|
|||
|
|
|
|||
|
|
Yohimbine exerts a stimulating action on the mood and may increase anxiety.
|
|||
|
|
Such actions have not been adequately studied or related to dosage. Although
|
|||
|
|
they appear to require hight doses of the drug. Yohimbine has a mild
|
|||
|
|
anti-diuretic action, probably via stimulation of hypothalamic centers and
|
|||
|
|
release of posterior pituitary hormone.
|
|||
|
|
|
|||
|
|
Reportedly, Yohimbine exerts no significant influence on cardiac stimulation
|
|||
|
|
and other effects mediated by beta-adrenergic receptors, its effect on blood
|
|||
|
|
pressure, if any, would be to lower it; however, no adequate studies are at
|
|||
|
|
hand to quantitate this effect in terms of Yohimbine dosage.
|
|||
|
|
|
|||
|
|
YOCON is indicated as a sympathicolytic and mydriatic. It may have activity
|
|||
|
|
as an aphrodisiac.
|
|||
|
|
|
|||
|
|
----------------------------------------------------------------
|
|||
|
|
Yohimbine "Alpha-2-Adrenergic blocker"
|
|||
|
|
|
|||
|
|
( From Corynanthe yohimbe & Rauwolfia serpentina )
|
|||
|
|
|
|||
|
|
/\ /\
|
|||
|
|
// \ _____ / \
|
|||
|
|
| || || |
|
|||
|
|
| || || N
|
|||
|
|
\\ / \ / \ /\
|
|||
|
|
\/ \N/ \/ \
|
|||
|
|
H | |
|
|||
|
|
\ /\
|
|||
|
|
\/ \
|
|||
|
|
| |
|
|||
|
|
/\ /
|
|||
|
|
H3COOC \/
|
|||
|
|
|
|
|||
|
|
OH
|
|||
|
|
|
|||
|
|
|
|||
|
|
Psychoactive Plants pharmacologically and/or botanically related to Yohimbe:
|
|||
|
|
|
|||
|
|
Rubiaceae [plant family]
|
|||
|
|
Corynanthe yohimbe (yohimbine)
|
|||
|
|
Caffea arabica (caffeine)
|
|||
|
|
Psychotria viridis (DMT/other indolealkylamines)
|
|||
|
|
Chinchona officinalis (Quinine Bark - antimalarial)
|
|||
|
|
(wild:S.America. cultiv:Java)
|
|||
|
|
Apocynaceae
|
|||
|
|
Rauwolfia serpentina
|
|||
|
|
Rauwolfia canescens (alpha-yohimbine)
|
|||
|
|
Aspidosperma quebracho blanco ("White Quebracho") (Quebrachamine)
|
|||
|
|
Anacardiaceae
|
|||
|
|
Loxoptrygium lorentzii ("Quebracho Colorado" for tanning leather)
|
|||
|
|
============================
|
|||
|
|
Medical Dictionary (Crown books $28)
|
|||
|
|
used in Southern Cameroon
|
|||
|
|
yohimbine same as quebrachine
|
|||
|
|
used as aphrodisiac, and to treat arteriosclerosis and angina pectoris
|
|||
|
|
==============================
|
|||
|
|
Merck Index 11th ed:
|
|||
|
|
--
|
|||
|
|
Raubasine (delta-yohimbine, tetrahydroserpentine, ajmalicine, Circolene
|
|||
|
|
Hydrosarpan, Isoarteril, Lamuran)
|
|||
|
|
From yohimbe & rauwolfia
|
|||
|
|
Antihypertensive, Anti-ischemic (cerebral & peripheral)
|
|||
|
|
--
|
|||
|
|
Other Yohimbe isomers etc:
|
|||
|
|
Pseudoyohimbine (from yohimbe)
|
|||
|
|
allo-yohimbine (alloyohimbine, dihydroyohimbine)
|
|||
|
|
alpha-yohimbine (from Rauwolfia canescens)
|
|||
|
|
(corynanthine,isoyohimbine,mesoyohimbine,rauwolscine)
|
|||
|
|
|
|||
|
|
|