diff --git a/pkgs/development/python-modules/pyspinel/default.nix b/pkgs/development/python-modules/pyspinel/default.nix
new file mode 100644
index 00000000000..990e2b28bd8
--- /dev/null
+++ b/pkgs/development/python-modules/pyspinel/default.nix
@@ -0,0 +1,21 @@
+{ buildPythonPackage, fetchPypi, lib, future, pyserial, ipaddress }:
+
+buildPythonPackage rec {
+  pname = "pyspinel";
+  version = "1.0.0a3";
+
+  src = fetchPypi {
+    inherit pname version;
+    sha256 = "0914a662d57a14bce9df21f22711b5c9b2fef37cf461be54ed35c6e229060fd4";
+  };
+
+  propagatedBuildInputs = [ pyserial ipaddress future ];
+
+  doCheck = false;
+
+  meta = {
+    description = "Interface to the OpenThread Network Co-Processor (NCP)";
+    homepage = "https://github.com/openthread/pyspinel";
+    maintainers = with lib.maintainers; [ gebner ];
+  };
+}
diff --git a/pkgs/top-level/python-packages.nix b/pkgs/top-level/python-packages.nix
index cc281887d8b..ec988ca4000 100644
--- a/pkgs/top-level/python-packages.nix
+++ b/pkgs/top-level/python-packages.nix
@@ -780,6 +780,8 @@ in {
     slurm = pkgs.slurm;
   };
 
+  pyspinel = callPackage ../development/python-modules/pyspinel {};
+
   pyssim = callPackage ../development/python-modules/pyssim { };
 
   pystache = callPackage ../development/python-modules/pystache { };