diff --git a/pkgs/applications/virtualization/OVMF/default.nix b/pkgs/applications/virtualization/OVMF/default.nix
index e475c4ed78a..e203106587b 100644
--- a/pkgs/applications/virtualization/OVMF/default.nix
+++ b/pkgs/applications/virtualization/OVMF/default.nix
@@ -17,9 +17,13 @@ let
     throw "Unsupported architecture";
 
   version = lib.getVersion edk2;
+  buildType = if stdenv.isDarwin then
+    "CLANGPDB"
+  else
+    "GCC5";
 in
 
-edk2.mkDerivation projectDscPath {
+edk2.mkDerivation projectDscPath buildType {
   name = "OVMF-${version}";
 
   outputs = [ "out" "fd" ];
@@ -57,6 +61,6 @@ edk2.mkDerivation projectDscPath {
     description = "Sample UEFI firmware for QEMU and KVM";
     homepage = https://github.com/tianocore/tianocore.github.io/wiki/OVMF;
     license = stdenv.lib.licenses.bsd2;
-    platforms = ["x86_64-linux" "i686-linux" "aarch64-linux"];
+    platforms = ["x86_64-linux" "i686-linux" "aarch64-linux" "x86_64-darwin"];
   };
 }
diff --git a/pkgs/development/compilers/edk2/default.nix b/pkgs/development/compilers/edk2/default.nix
index 47aa8e249f8..2ba02a29488 100644
--- a/pkgs/development/compilers/edk2/default.nix
+++ b/pkgs/development/compilers/edk2/default.nix
@@ -1,4 +1,17 @@
-{ stdenv, fetchgit, fetchpatch, libuuid, python3, iasl, bc }:
+{
+    stdenv,
+    clangStdenv,
+    fetchgit,
+    fetchpatch,
+    libuuid,
+    python3,
+    iasl,
+    bc,
+    clang_9,
+    llvmPackages_9,
+    overrideCC,
+    lib,
+}:
 
 let
   pythonEnv = python3.withPackages (ps: [ps.tkinter]);
@@ -12,7 +25,12 @@ else if stdenv.isAarch64 then
 else
   throw "Unsupported architecture";
 
-edk2 = stdenv.mkDerivation {
+buildStdenv = if stdenv.isDarwin then
+  overrideCC clangStdenv [ clang_9 llvmPackages_9.llvm llvmPackages_9.lld ]
+else
+  stdenv;
+
+edk2 = buildStdenv.mkDerivation {
   pname = "edk2";
   version = "201911";
 
@@ -25,8 +43,10 @@ edk2 = stdenv.mkDerivation {
 
   buildInputs = [ libuuid pythonEnv ];
 
-  makeFlags = [ "-C BaseTools" ];
-  NIX_CFLAGS_COMPILE = "-Wno-return-type -Wno-error=stringop-truncation";
+  makeFlags = [ "-C BaseTools" ]
+    ++ lib.optional (stdenv.isDarwin) [ "BUILD_CC=clang BUILD_CXX=clang++ BUILD_AS=clang" ];
+
+  NIX_CFLAGS_COMPILE = "-Wno-return-type" + lib.optionalString (!stdenv.isDarwin) " -Wno-error=stringop-truncation";
 
   hardeningDisable = [ "format" "fortify" ];
 
@@ -38,15 +58,15 @@ edk2 = stdenv.mkDerivation {
 
   enableParallelBuilding = true;
 
-  meta = with stdenv.lib; {
+  meta = with lib; {
     description = "Intel EFI development kit";
     homepage = https://sourceforge.net/projects/edk2/;
     license = licenses.bsd2;
-    platforms = [ "x86_64-linux" "i686-linux" "aarch64-linux" ];
+    platforms = [ "x86_64-linux" "i686-linux" "aarch64-linux" "x86_64-darwin" ];
   };
 
   passthru = {
-    mkDerivation = projectDscPath: attrs: stdenv.mkDerivation ({
+    mkDerivation = projectDscPath: buildType: attrs: buildStdenv.mkDerivation ({
       inherit (edk2) src;
 
       buildInputs = [ bc pythonEnv ] ++ attrs.buildInputs or [];
@@ -65,7 +85,7 @@ edk2 = stdenv.mkDerivation {
 
       buildPhase = ''
         runHook preBuild
-        build -a ${targetArch} -b RELEASE -t GCC5 -p ${projectDscPath} -n $NIX_BUILD_CORES $buildFlags
+        build -a ${targetArch} -b RELEASE -t ${buildType} -p ${projectDscPath} -n $NIX_BUILD_CORES $buildFlags
         runHook postBuild
       '';