diff --git a/pkgs/development/libraries/libglvnd/default.nix b/pkgs/development/libraries/libglvnd/default.nix
index 1ef63c2406d..3124486f07a 100644
--- a/pkgs/development/libraries/libglvnd/default.nix
+++ b/pkgs/development/libraries/libglvnd/default.nix
@@ -35,8 +35,11 @@ stdenv.mkDerivation rec {
     "-Wno-error=array-bounds"
   ] ++ lib.optional stdenv.cc.isClang "-Wno-error");
 
-  # Indirectly: https://bugs.freedesktop.org/show_bug.cgi?id=35268
-  configureFlags  = lib.optional stdenv.hostPlatform.isMusl "--disable-tls";
+  configureFlags  = []
+    # Indirectly: https://bugs.freedesktop.org/show_bug.cgi?id=35268
+    ++ lib.optional stdenv.hostPlatform.isMusl "--disable-tls"
+    # Remove when aarch64-darwin asm support is upstream: https://gitlab.freedesktop.org/glvnd/libglvnd/-/issues/216
+    ++ lib.optional (stdenv.hostPlatform.isDarwin && stdenv.hostPlatform.isAarch64) "--disable-asm";
 
   outputs = [ "out" "dev" ];