diff --git a/pkgs/development/libraries/science/biology/elastix/default.nix b/pkgs/development/libraries/science/biology/elastix/default.nix
index 4d98b12928f..e55a72fb9f8 100644
--- a/pkgs/development/libraries/science/biology/elastix/default.nix
+++ b/pkgs/development/libraries/science/biology/elastix/default.nix
@@ -1,32 +1,26 @@
-{ stdenv, fetchFromGitHub, fetchpatch, cmake, itk, python3 }:
+{ stdenv, fetchFromGitHub, fetchpatch, cmake, itk, python3, Cocoa }:
 
 stdenv.mkDerivation rec {
   pname    = "elastix";
-  version = "5.0.0";
+  version = "5.0.1";
 
   src = fetchFromGitHub {
     owner  = "SuperElastix";
     repo   = pname;
     rev    = version;
-    sha256 = "1zrl7rz4lwsx88b2shnl985f3a97lmp4ksbd437h9y0hfjq8l0lj";
+    sha256 = "1mx8kkak2d3ibfrxrh8jkmh2zkdlgl9h578wiw3617zcwaa97bxw";
   };
 
   patches = [
     (fetchpatch {
-      name = "itk-5.1-compat.patch";
-      url = "https://github.com/SuperElastix/elastix/commit/402e9a26f22f805b8f2db00c00e59f75fa1783ad.patch";
-      sha256 = "1il6gc1lgy78i0w6gkkppr61nh6g0yjspbfk19hcz20778m5jhz9";
-    })
-    (fetchpatch {
-      name = "fix-osx-build.patch";
-      url = "https://github.com/SuperElastix/elastix/commit/52e1dc3928046f9fbb85d4b2ecd0d5175fa9695d.patch";
-      sha256 = "1hf7kgx1jv497pf0x5wj79sy1wncxcvhrkix9w086lcr8zwxvn9q";
+      name = "install-executables.patch";  # https://github.com/SuperElastix/elastix/issues/305
+      url = "https://github.com/SuperElastix/elastix/commit/8e26cdc0d66f6030c7be085fdc424d84d4fc7546.patch";
+      sha256 = "12y9wbpi9jlarnw6fk4iby97jxvx5g4daq9zqblbcmn51r134bj5";
     })
   ];
 
-
   nativeBuildInputs = [ cmake python3 ];
-  buildInputs = [ itk ];
+  buildInputs = [ itk ] ++ stdenv.lib.optionals stdenv.isDarwin [ Cocoa ];
 
   doCheck = !stdenv.isDarwin;  # usual dynamic linker issues
 
diff --git a/pkgs/top-level/all-packages.nix b/pkgs/top-level/all-packages.nix
index 3a15e49b650..667503f6e80 100644
--- a/pkgs/top-level/all-packages.nix
+++ b/pkgs/top-level/all-packages.nix
@@ -12342,7 +12342,9 @@ in
 
   egl-wayland = callPackage ../development/libraries/egl-wayland {};
 
-  elastix = callPackage ../development/libraries/science/biology/elastix { };
+  elastix = callPackage ../development/libraries/science/biology/elastix {
+    inherit (darwin.apple_sdk.frameworks) Cocoa;
+  };
 
   enchant1 = callPackage ../development/libraries/enchant/1.x.nix { };