diff --git a/pkgs/development/tools/build-managers/cmake/setup-hook.sh b/pkgs/development/tools/build-managers/cmake/setup-hook.sh
index f095103ee04..c21e10bb061 100755
--- a/pkgs/development/tools/build-managers/cmake/setup-hook.sh
+++ b/pkgs/development/tools/build-managers/cmake/setup-hook.sh
@@ -75,6 +75,13 @@ cmakeConfigurePhase() {
     # And build always Release, to ensure optimisation flags
     cmakeFlags="-DCMAKE_BUILD_TYPE=${cmakeBuildType:-Release} -DCMAKE_SKIP_BUILD_RPATH=ON $cmakeFlags"
 
+    # Disable user package registry to avoid potential side effects
+    # and unecessary attempts to access non-existent home folder
+    # https://cmake.org/cmake/help/latest/manual/cmake-packages.7.html#disabling-the-package-registry
+    cmakeFlags="-DCMAKE_EXPORT_NO_PACKAGE_REGISTRY=ON $cmakeFlags"
+    cmakeFlags="-DCMAKE_FIND_PACKAGE_NO_PACKAGE_REGISTRY=ON $cmakeFlags"
+    cmakeFlags="-DCMAKE_FIND_PACKAGE_NO_SYSTEM_PACKAGE_REGISTRY=ON $cmakeFlags"
+
     if [ "$buildPhase" = ninjaBuildPhase ]; then
         cmakeFlags="-GNinja $cmakeFlags"
     fi