diff --git a/pkgs/applications/science/math/mathematica/default.nix b/pkgs/applications/science/math/mathematica/default.nix
index 7cd1b2eb99f..5553bb0505f 100644
--- a/pkgs/applications/science/math/mathematica/default.nix
+++ b/pkgs/applications/science/math/mathematica/default.nix
@@ -9,6 +9,7 @@
 , freetype
 , gcc
 , glib
+, libssh2
 , ncurses
 , opencv
 , openssl
@@ -44,9 +45,11 @@ stdenv.mkDerivation rec {
     gcc.cc
     gcc.libc
     glib
+    libssh2
     ncurses
     opencv
     openssl
+    stdenv.cc.cc.lib
     unixODBC
     xkeyboard_config
     libxml2
@@ -93,7 +96,7 @@ stdenv.mkDerivation rec {
     # Fix library paths
     cd $out/libexec/Mathematica/Executables
     for path in mathematica MathKernel Mathematica WolframKernel wolfram math; do
-      sed -i -e "2iexport LD_LIBRARY_PATH=${zlib}/lib:\''${LD_LIBRARY_PATH}\n" $path
+      sed -i -e "2iexport LD_LIBRARY_PATH=${zlib}/lib:${stdenv.cc.cc.lib}/lib:${libssh2}/lib:\''${LD_LIBRARY_PATH}\n" $path
     done
 
     # Fix xkeyboard config path for Qt
@@ -102,7 +105,7 @@ stdenv.mkDerivation rec {
     done
 
     # Remove some broken libraries
-    rm $out/libexec/Mathematica/SystemFiles/Libraries/Linux-x86-64/libz.so*
+    rm -f $out/libexec/Mathematica/SystemFiles/Libraries/Linux-x86-64/libz.so*
   '';
 
   preFixup = ''
diff --git a/pkgs/applications/science/math/mathematica/l10ns.nix b/pkgs/applications/science/math/mathematica/l10ns.nix
index 51fb489be7e..c75c91be059 100644
--- a/pkgs/applications/science/math/mathematica/l10ns.nix
+++ b/pkgs/applications/science/math/mathematica/l10ns.nix
@@ -7,6 +7,12 @@
 let allVersions = with lib; flip map
   # N.B. Versions in this list should be ordered from newest to oldest.
   [
+    {
+      version = "12.1.0";
+      lang = "en";
+      language = "English";
+      sha256 = "15m9l20jvkxh5w6mbp81ys7mx2lx5j8acw5gz0il89lklclgb8z7";
+    }
     {
       version = "12.0.0";
       lang = "en";