diff --git a/pkgs/development/libraries/science/math/openblas/default.nix b/pkgs/development/libraries/science/math/openblas/default.nix
index 42eaf71942e..5b3fd57551d 100644
--- a/pkgs/development/libraries/science/math/openblas/default.nix
+++ b/pkgs/development/libraries/science/math/openblas/default.nix
@@ -115,7 +115,7 @@ stdenv.mkDerivation {
       "NUM_THREADS=64"
       "INTERFACE64=${if blas64 then "1" else "0"}"
       "NO_STATIC=1"
-    ]
+    ] ++ stdenv.lib.optional (stdenv.hostPlatform.libc == "musl") "NO_AFFINITY=1"
     ++ mapAttrsToList (var: val: var + "=" + val) config;
 
   doCheck = true;