diff --git a/pkgs/development/python-modules/dnachisel/default.nix b/pkgs/development/python-modules/dnachisel/default.nix
new file mode 100644
index 00000000000..465f1bb5b4d
--- /dev/null
+++ b/pkgs/development/python-modules/dnachisel/default.nix
@@ -0,0 +1,41 @@
+{ lib
+, buildPythonPackage
+, fetchPypi
+, biopython
+, docopt
+, flametree
+, numpy
+, proglog
+, python-codon-tables
+ }:
+
+buildPythonPackage rec {
+  pname = "dnachisel";
+  version = "3.2.5";
+
+  src = fetchPypi {
+    inherit pname version;
+    sha256 = "35301c5eda0baca5902403504e0b5a22eb65da92c2bbd23199d95c4a6bf0ef37";
+  };
+
+  propagatedBuildInputs = [
+    biopython
+    docopt
+    flametree
+    numpy
+    proglog
+    python-codon-tables
+  ];
+
+  # no tests in tarball
+  doCheck = false;
+
+  pythonImportsCheck = [ "dnachisel" ];
+
+  meta = with lib; {
+    homepage = "https://github.com/Edinburgh-Genome-Foundry/DnaChisel";
+    description = "Optimize DNA sequences under constraints";
+    license = licenses.mit;
+    maintainers = with maintainers; [ prusnak ];
+  };
+}
diff --git a/pkgs/top-level/python-packages.nix b/pkgs/top-level/python-packages.nix
index af921af1cd9..05abf503128 100644
--- a/pkgs/top-level/python-packages.nix
+++ b/pkgs/top-level/python-packages.nix
@@ -1793,6 +1793,8 @@ in {
 
   dm-sonnet = callPackage ../development/python-modules/dm-sonnet { };
 
+  dnachisel = callPackage ../development/python-modules/dnachisel { };
+
   dnslib = callPackage ../development/python-modules/dnslib { };
 
   dnspython = if isPy3k then