diff --git a/pkgs/applications/virtualization/virtualbox/default.nix b/pkgs/applications/virtualization/virtualbox/default.nix
index fe19f1f4a3e..4f792b4eb6e 100644
--- a/pkgs/applications/virtualization/virtualbox/default.nix
+++ b/pkgs/applications/virtualization/virtualbox/default.nix
@@ -23,7 +23,7 @@ let
   buildType = "release";
   # Use maintainers/scripts/update.nix to update the version and all related hashes or
   # change the hashes in extpack.nix and guest-additions/default.nix as well manually.
-  version = "6.1.18";
+  version = "6.1.22";
 
   iasl' = iasl.overrideAttrs (old: rec {
     inherit (old) pname;
@@ -40,7 +40,7 @@ in stdenv.mkDerivation {
 
   src = fetchurl {
     url = "https://download.virtualbox.org/virtualbox/${version}/VirtualBox-${version}.tar.bz2";
-    sha256 = "108d42b9b391b7a332a33df1662cf7b0e9d9a80f3079d16288d8b9487f427d40";
+    sha256 = "99816d2a15205d49362a31e8ffeb8262d2fa0678c751dfd0a7c43b2faca8be49";
   };
 
   outputs = [ "out" "modsrc" ];
@@ -103,8 +103,6 @@ in stdenv.mkDerivation {
       qtPluginPath = "${qtbase.bin}/${qtbase.qtPluginPrefix}:${qtsvg.bin}/${qtbase.qtPluginPrefix}:${qtwayland.bin}/${qtbase.qtPluginPrefix}";
     })
   ++ [
-    # NOTE: the patch for linux 5.11 can be removed when the next version of VirtualBox is released
-    ./linux-5-11.patch
     ./qtx11extras.patch
   ];
 
diff --git a/pkgs/applications/virtualization/virtualbox/extpack.nix b/pkgs/applications/virtualization/virtualbox/extpack.nix
index 4aa3ed1fd49..8c64337c6cb 100644
--- a/pkgs/applications/virtualization/virtualbox/extpack.nix
+++ b/pkgs/applications/virtualization/virtualbox/extpack.nix
@@ -12,7 +12,7 @@ fetchurl rec {
     # Manually sha256sum the extensionPack file, must be hex!
     # Thus do not use `nix-prefetch-url` but instead plain old `sha256sum`.
     # Checksums can also be found at https://www.virtualbox.org/download/hashes/${version}/SHA256SUMS
-    let value = "d609e35accff5c0819ca9be47de302abf094dc1b6d4c54da8fdda639671f267e";
+    let value = "6d33d9cc1c5a8f8a2a70e5aaaa778a341322d2ba7eb34f7de420fb5f312b9e87";
     in assert (builtins.stringLength value) == 64; value;
 
   meta = {
diff --git a/pkgs/applications/virtualization/virtualbox/guest-additions/default.nix b/pkgs/applications/virtualization/virtualbox/guest-additions/default.nix
index c35ebdb81d0..218d4983ca5 100644
--- a/pkgs/applications/virtualization/virtualbox/guest-additions/default.nix
+++ b/pkgs/applications/virtualization/virtualbox/guest-additions/default.nix
@@ -27,7 +27,7 @@ in stdenv.mkDerivation rec {
 
   src = fetchurl {
     url = "http://download.virtualbox.org/virtualbox/${version}/VBoxGuestAdditions_${version}.iso";
-    sha256 = "904432eb331d7ae517afaa4e4304e6492b7947b46ecb8267de7ef792c4921b4c";
+    sha256 = "bffc316a7b8d5ed56d830e9f6aef02b4e5ffc28674032142e96ffbedd905f8c9";
   };
 
   KERN_DIR = "${kernel.dev}/lib/modules/${kernel.modDirVersion}/build";
diff --git a/pkgs/applications/virtualization/virtualbox/linux-5-11.patch b/pkgs/applications/virtualization/virtualbox/linux-5-11.patch
deleted file mode 100644
index 66b70bf0d97..00000000000
--- a/pkgs/applications/virtualization/virtualbox/linux-5-11.patch
+++ /dev/null
@@ -1,12 +0,0 @@
-diff --git a/src/VBox/HostDrivers/VBoxNetFlt/linux/VBoxNetFlt-linux.c b/src/VBox/HostDrivers/VBoxNetFlt/linux/VBoxNetFlt-linux.c
-index 7033b45..c8178a6 100644
---- a/src/VBox/HostDrivers/VBoxNetFlt/linux/VBoxNetFlt-linux.c
-+++ b/src/VBox/HostDrivers/VBoxNetFlt/linux/VBoxNetFlt-linux.c
-@@ -39,6 +39,7 @@
- #endif
- #include <linux/netdevice.h>
- #include <linux/etherdevice.h>
-+#include <linux/ethtool.h>
- #include <linux/rtnetlink.h>
- #include <linux/miscdevice.h>
- #include <linux/inetdevice.h>