diff --git a/pkgs/development/tools/build-managers/cmake/setup-hook.sh b/pkgs/development/tools/build-managers/cmake/setup-hook.sh
index 6f3d33bcaa7..5479067d637 100755
--- a/pkgs/development/tools/build-managers/cmake/setup-hook.sh
+++ b/pkgs/development/tools/build-managers/cmake/setup-hook.sh
@@ -53,10 +53,6 @@ cmakeConfigurePhase() {
     # we never want to use the global macOS SDK
     cmakeFlags="-DCMAKE_OSX_SYSROOT= $cmakeFlags"
 
-    # disable OSX deployment target
-    # we don't want our binaries to have a "minimum" OSX version
-    cmakeFlags="-DCMAKE_OSX_DEPLOYMENT_TARGET= $cmakeFlags"
-
     # correctly detect our clang compiler
     cmakeFlags="-DCMAKE_POLICY_DEFAULT_CMP0025=NEW $cmakeFlags"
 
diff --git a/pkgs/development/tools/misc/ccls/default.nix b/pkgs/development/tools/misc/ccls/default.nix
index c3a0e57bd7f..f442c16e351 100644
--- a/pkgs/development/tools/misc/ccls/default.nix
+++ b/pkgs/development/tools/misc/ccls/default.nix
@@ -15,10 +15,7 @@ stdenv.mkDerivation rec {
   nativeBuildInputs = [ cmake ];
   buildInputs = with llvmPackages; [ clang-unwrapped llvm rapidjson ];
 
-  cmakeFlags = [
-    "-DCCLS_VERSION=${version}"
-    "-DCMAKE_OSX_DEPLOYMENT_TARGET=${stdenv.macosVersionMin or ""}"
-  ];
+  cmakeFlags = [ "-DCCLS_VERSION=${version}" ];
 
   preConfigure = ''
     cmakeFlagsArray+=(-DCMAKE_CXX_FLAGS="-fvisibility=hidden -fno-rtti")
diff --git a/pkgs/development/tools/misc/cquery/default.nix b/pkgs/development/tools/misc/cquery/default.nix
index ccb4dd5b15a..87b3cbb7121 100644
--- a/pkgs/development/tools/misc/cquery/default.nix
+++ b/pkgs/development/tools/misc/cquery/default.nix
@@ -26,7 +26,6 @@ stdenv.mkDerivation {
   cmakeFlags = [
     "-DSYSTEM_CLANG=ON"
     "-DCLANG_CXX=ON"
-    "-DCMAKE_OSX_DEPLOYMENT_TARGET=${stdenv.macosVersionMin or ""}"
   ];
 
   shell = runtimeShell;
diff --git a/pkgs/servers/sql/mysql/8.0.x.nix b/pkgs/servers/sql/mysql/8.0.x.nix
index 64b4417ea60..3c1d1f6645c 100644
--- a/pkgs/servers/sql/mysql/8.0.x.nix
+++ b/pkgs/servers/sql/mysql/8.0.x.nix
@@ -31,7 +31,6 @@ self = stdenv.mkDerivation rec {
   outputs = [ "out" "static" ];
 
   cmakeFlags = [
-    "-DCMAKE_OSX_DEPLOYMENT_TARGET=${stdenv.macosVersionMin or ""}" # For std::shared_timed_mutex.
     "-DCMAKE_SKIP_BUILD_RPATH=OFF" # To run libmysql/libmysql_api_test during build.
     "-DFORCE_UNSUPPORTED_COMPILER=1" # To configure on Darwin.
     "-DWITH_ROUTER=OFF" # It may be packaged separately.