diff --git a/pkgs/development/python-modules/Rtree/default.nix b/pkgs/development/python-modules/Rtree/default.nix
new file mode 100644
index 00000000000..7953829465b
--- /dev/null
+++ b/pkgs/development/python-modules/Rtree/default.nix
@@ -0,0 +1,29 @@
+{ stdenv, buildPythonPackage, fetchPypi, libspatialindex, numpy }:
+
+buildPythonPackage rec {
+  pname = "Rtree";
+  version = "0.8.3";
+
+  src = fetchPypi {
+    inherit pname version;
+    sha256 = "0jc62jbcqqpjcwcly7l9zk25bg72mrxmjykpvfiscgln00qczfbc";
+  };
+
+  propagatedBuildInputs = [ libspatialindex ];
+
+  patchPhase = ''
+    substituteInPlace rtree/core.py --replace \
+      "find_library('spatialindex_c')" "'${libspatialindex}/lib/libspatialindex_c${stdenv.hostPlatform.extensions.sharedLibrary}'"
+  '';
+
+  # Tests appear to be broken due to mysterious memory unsafe issues. See #36760
+  doCheck = false;
+  checkInputs = [ numpy ];
+
+  meta = with stdenv.lib; {
+    description = "R-Tree spatial index for Python GIS";
+    homepage = https://toblerity.org/rtree/;
+    license = licenses.lgpl21;
+    maintainers = with maintainers; [ bgamari ];
+  };
+}
diff --git a/pkgs/top-level/python-packages.nix b/pkgs/top-level/python-packages.nix
index 85179ccce3f..143aa179f91 100644
--- a/pkgs/top-level/python-packages.nix
+++ b/pkgs/top-level/python-packages.nix
@@ -14467,6 +14467,8 @@ in {
     };
   };
 
+  Rtree = callPackage ../development/python-modules/Rtree { inherit (pkgs) libspatialindex; };
+
   squaremap = buildPythonPackage rec {
     name = "squaremap-1.0.4";
     disabled = isPy3k;