diff --git a/pkgs/applications/science/misc/root/default.nix b/pkgs/applications/science/misc/root/default.nix
index 385500459de..0eb846a73a3 100644
--- a/pkgs/applications/science/misc/root/default.nix
+++ b/pkgs/applications/science/misc/root/default.nix
@@ -6,11 +6,11 @@
 
 stdenv.mkDerivation rec {
   pname = "root";
-  version = "6.20.08";
+  version = "6.22.06";
 
   src = fetchurl {
     url = "https://root.cern.ch/download/root_v${version}.source.tar.gz";
-    sha256 = "1s9sqapw2f31m3gcm8nyg7dl8g9mgj92ny28jsli9j08955j4byh";
+    sha256 = "0mqvj42nax0bmz8h83jjlwjm3xxjy1n0n10inc8csip9ly28fs64";
   };
 
   nativeBuildInputs = [ makeWrapper cmake pkgconfig ];
@@ -70,7 +70,14 @@ stdenv.mkDerivation rec {
     "-Dxrootd=OFF"
   ]
   ++ stdenv.lib.optional (stdenv.cc.libc != null) "-DC_INCLUDE_DIRS=${stdenv.lib.getDev stdenv.cc.libc}/include"
-  ++ stdenv.lib.optional stdenv.isDarwin "-DOPENGL_INCLUDE_DIR=${OpenGL}/Library/Frameworks";
+  ++ stdenv.lib.optionals stdenv.isDarwin [
+    "-DOPENGL_INCLUDE_DIR=${OpenGL}/Library/Frameworks"
+    "-DCMAKE_DISABLE_FIND_PACKAGE_Python2=TRUE"
+
+    # fatal error: module map file '/nix/store/<hash>-Libsystem-osx-10.12.6/include/module.modulemap' not found
+    # fatal error: could not build module '_Builtin_intrinsics'
+    "-Druntime_cxxmodules=OFF"
+  ];
 
   enableParallelBuilding = true;
 
diff --git a/pkgs/applications/science/misc/root/sw_vers.patch b/pkgs/applications/science/misc/root/sw_vers.patch
index 339ac2f5bd2..b2ee1b6a4ce 100644
--- a/pkgs/applications/science/misc/root/sw_vers.patch
+++ b/pkgs/applications/science/misc/root/sw_vers.patch
@@ -1,19 +1,7 @@
-diff a/build/unix/compiledata.sh b/build/unix/compiledata.sh
---- a/build/unix/compiledata.sh
-+++ b/build/unix/compiledata.sh
-@@ -41,7 +41,7 @@ EXPLLINKLIBS="\$LinkedLibs"
- 
- if [ "$ARCH" = "macosx" ] || [ "$ARCH" = "macosx64" ] || \
-    [ "$ARCH" = "macosxicc" ]; then
--   macosx_minor=`sw_vers | sed -n 's/ProductVersion://p' | cut -d . -f 2`
-+   macosx_minor=12
-    SOEXT="so"
-    if [ $macosx_minor -ge 5 ]; then
-       if [ "x`echo $SOFLAGS | grep -- '-install_name'`" != "x" ]; then
 diff a/cmake/modules/SetUpMacOS.cmake b/cmake/modules/SetUpMacOS.cmake
 --- a/cmake/modules/SetUpMacOS.cmake
 +++ b/cmake/modules/SetUpMacOS.cmake
-@@ -8,17 +8,8 @@ set(ROOT_ARCHITECTURE macosx)
+@@ -8,17 +8,10 @@ set(ROOT_ARCHITECTURE macosx)
  set(ROOT_PLATFORM macosx)
  
  if (CMAKE_SYSTEM_NAME MATCHES Darwin)
@@ -21,8 +9,8 @@ diff a/cmake/modules/SetUpMacOS.cmake b/cmake/modules/SetUpMacOS.cmake
 -                  COMMAND cut -d . -f 1-2
 -                  OUTPUT_VARIABLE MACOSX_VERSION OUTPUT_STRIP_TRAILING_WHITESPACE)
 -
--  MESSAGE(STATUS "Found a Mac OS X System ${MACOSX_VERSION}")
--
+   MESSAGE(STATUS "Found a macOS system ${MACOSX_VERSION}")
+ 
 -  if(MACOSX_VERSION VERSION_GREATER 10.7 AND ${CMAKE_CXX_COMPILER_ID} MATCHES Clang)
      set(libcxx ON CACHE BOOL "Build using libc++" FORCE)
 -  endif()
@@ -31,7 +19,7 @@ diff a/cmake/modules/SetUpMacOS.cmake b/cmake/modules/SetUpMacOS.cmake
      #TODO: check haveconfig and rpath -> set rpath true
      #TODO: check Thread, define link command
      #TODO: more stuff check configure script
-@@ -31,23 +22,7 @@ if (CMAKE_SYSTEM_NAME MATCHES Darwin)
+@@ -37,23 +30,7 @@ if (CMAKE_SYSTEM_NAME MATCHES Darwin)
         SET(CMAKE_CXX_FLAGS "${CMAKE_CXX_FLAGS} -m64")
         SET(CMAKE_C_FLAGS "${CMAKE_C_FLAGS} -m64")
         SET(CMAKE_Fortran_FLAGS "${CMAKE_Fortran_FLAGS} -m64")
@@ -56,7 +44,7 @@ diff a/cmake/modules/SetUpMacOS.cmake b/cmake/modules/SetUpMacOS.cmake
  
    if (CMAKE_COMPILER_IS_GNUCXX)
       message(STATUS "Found GNU compiler collection")
-@@ -98,7 +73,6 @@ if (CMAKE_SYSTEM_NAME MATCHES Darwin)
+@@ -115,7 +92,6 @@ if (CMAKE_SYSTEM_NAME MATCHES Darwin)
    endif()
  
    #---Set Linker flags----------------------------------------------------------------------
@@ -67,24 +55,24 @@ diff a/cmake/modules/SetUpMacOS.cmake b/cmake/modules/SetUpMacOS.cmake
 diff a/config/root-config.in b/config/root-config.in
 --- a/config/root-config.in
 +++ b/config/root-config.in
-@@ -305,12 +305,6 @@ macosxicc)
-    auxlibs="-lm -ldl"
+@@ -312,12 +312,6 @@ macosxicc)
     ;;
- macosx64)
--   # MacOS X with gcc (GNU cc v4.x) in 64 bit mode
+ macosx64|macosxarm64)
+    # MacOS X with gcc (GNU cc v4.x) in 64 bit mode
+-   macosx_major=`sw_vers | sed -n 's/ProductVersion://p' | cut -d . -f 1 | sed -e 's/^[[:space:]]*//'`
 -   macosx_minor=`sw_vers | sed -n 's/ProductVersion://p' | cut -d . -f 2`
 -   # cannot find the one linked to libGraf if relocated after built
--   if [ $macosx_minor -le 4 ]; then
+-   if [ $macosx_major -eq 10 -a $macosx_minor -le 4 ]; then
 -      rootlibs="$rootlibs -lfreetype"
 -   fi
     auxcflags="${cxxversionflag} -m64"
     auxldflags="-m64"
     auxlibs="-lm -ldl"
-@@ -371,18 +365,11 @@ freebsd* | openbsd* | linux*)
+@@ -378,18 +372,11 @@ freebsd* | openbsd* | linux*)
     done
     ;;
  macosx*)
--   if [ $macosx_minor -ge 5 ]; then
+-   if [ \( $macosx_major -eq 10 -a $macosx_minor -ge 5 \) -o $macosx_major -gt 10  ]; then
        auxcflags="-pthread $auxcflags"
        auxlibs="-lpthread $auxlibs"
 -   else
@@ -93,7 +81,7 @@ diff a/config/root-config.in b/config/root-config.in
 -   fi
     for f in $features ; do
        if test "x$f" = "xrpath" ; then
--         if [ $macosx_minor -ge 5 ]; then
+-         if [ \( $macosx_major -eq 10 -a $macosx_minor -ge 5 \) -o $macosx_major -gt 10  ]; then
              auxlibs="-Wl,-rpath,$libdir $auxlibs"
 -         fi
        fi