diff --git a/pkgs/development/compilers/gcc/10/default.nix b/pkgs/development/compilers/gcc/10/default.nix
index 1502b09cca6..c265fff2215 100644
--- a/pkgs/development/compilers/gcc/10/default.nix
+++ b/pkgs/development/compilers/gcc/10/default.nix
@@ -186,8 +186,7 @@ stdenv.mkDerivation ({
 
   dontDisableStatic = true;
 
-  # TODO(@Ericson2314): Always pass "--target" and always prefix.
-  configurePlatforms = [ "build" "host" ] ++ lib.optional (targetPlatform != hostPlatform) "target";
+  configurePlatforms = [ "build" "host" "target" ];
 
   configureFlags = import ../common/configure-flags.nix {
     inherit
diff --git a/pkgs/development/compilers/gcc/4.8/default.nix b/pkgs/development/compilers/gcc/4.8/default.nix
index 6a2121a8298..957c85cfde5 100644
--- a/pkgs/development/compilers/gcc/4.8/default.nix
+++ b/pkgs/development/compilers/gcc/4.8/default.nix
@@ -196,8 +196,7 @@ stdenv.mkDerivation ({
 
   dontDisableStatic = true;
 
-  # TODO(@Ericson2314): Always pass "--target" and always prefix.
-  configurePlatforms = [ "build" "host" ] ++ lib.optional (targetPlatform != hostPlatform) "target";
+  configurePlatforms = [ "build" "host" "target" ];
 
   configureFlags = import ../common/configure-flags.nix {
     inherit
diff --git a/pkgs/development/compilers/gcc/4.9/default.nix b/pkgs/development/compilers/gcc/4.9/default.nix
index 709288559d1..5d30f80edb2 100644
--- a/pkgs/development/compilers/gcc/4.9/default.nix
+++ b/pkgs/development/compilers/gcc/4.9/default.nix
@@ -209,8 +209,7 @@ stdenv.mkDerivation ({
 
   dontDisableStatic = true;
 
-  # TODO(@Ericson2314): Always pass "--target" and always prefix.
-  configurePlatforms = [ "build" "host" ] ++ lib.optional (targetPlatform != hostPlatform) "target";
+  configurePlatforms = [ "build" "host" "target" ];
 
   configureFlags = import ../common/configure-flags.nix {
     inherit
diff --git a/pkgs/development/compilers/gcc/6/default.nix b/pkgs/development/compilers/gcc/6/default.nix
index 93c9dde61fc..0ac54e093b4 100644
--- a/pkgs/development/compilers/gcc/6/default.nix
+++ b/pkgs/development/compilers/gcc/6/default.nix
@@ -232,8 +232,7 @@ stdenv.mkDerivation ({
 
   dontDisableStatic = true;
 
-  # TODO(@Ericson2314): Always pass "--target" and always prefix.
-  configurePlatforms = [ "build" "host" ] ++ lib.optional (targetPlatform != hostPlatform) "target";
+  configurePlatforms = [ "build" "host" "target" ];
 
   configureFlags = import ../common/configure-flags.nix {
     inherit
diff --git a/pkgs/development/compilers/gcc/7/default.nix b/pkgs/development/compilers/gcc/7/default.nix
index d9b4c639b5a..233d022514e 100644
--- a/pkgs/development/compilers/gcc/7/default.nix
+++ b/pkgs/development/compilers/gcc/7/default.nix
@@ -197,8 +197,7 @@ stdenv.mkDerivation ({
 
   dontDisableStatic = true;
 
-  # TODO(@Ericson2314): Always pass "--target" and always prefix.
-  configurePlatforms = [ "build" "host" ] ++ lib.optional (targetPlatform != hostPlatform) "target";
+  configurePlatforms = [ "build" "host" "target" ];
 
   configureFlags = import ../common/configure-flags.nix {
     inherit
diff --git a/pkgs/development/compilers/gcc/8/default.nix b/pkgs/development/compilers/gcc/8/default.nix
index 6ecf462d54d..4e57e43437f 100644
--- a/pkgs/development/compilers/gcc/8/default.nix
+++ b/pkgs/development/compilers/gcc/8/default.nix
@@ -182,8 +182,7 @@ stdenv.mkDerivation ({
 
   dontDisableStatic = true;
 
-  # TODO(@Ericson2314): Always pass "--target" and always prefix.
-  configurePlatforms = [ "build" "host" ] ++ lib.optional (targetPlatform != hostPlatform) "target";
+  configurePlatforms = [ "build" "host" "target" ];
 
   configureFlags = import ../common/configure-flags.nix {
     inherit
diff --git a/pkgs/development/compilers/gcc/9/default.nix b/pkgs/development/compilers/gcc/9/default.nix
index 7f35f5c7bb9..92810ecffaf 100644
--- a/pkgs/development/compilers/gcc/9/default.nix
+++ b/pkgs/development/compilers/gcc/9/default.nix
@@ -199,8 +199,7 @@ stdenv.mkDerivation ({
 
   dontDisableStatic = true;
 
-  # TODO(@Ericson2314): Always pass "--target" and always prefix.
-  configurePlatforms = [ "build" "host" ] ++ lib.optional (targetPlatform != hostPlatform) "target";
+  configurePlatforms = [ "build" "host" "target" ];
 
   configureFlags = import ../common/configure-flags.nix {
     inherit
diff --git a/pkgs/development/compilers/gcc/common/configure-flags.nix b/pkgs/development/compilers/gcc/common/configure-flags.nix
index fc4fbb34c50..4cf06cd4107 100644
--- a/pkgs/development/compilers/gcc/common/configure-flags.nix
+++ b/pkgs/development/compilers/gcc/common/configure-flags.nix
@@ -44,6 +44,9 @@ let
   crossMingw = targetPlatform != hostPlatform && targetPlatform.libc == "msvcrt";
   crossDarwin = targetPlatform != hostPlatform && targetPlatform.libc == "libSystem";
 
+  targetPrefix = lib.optionalString (stdenv.targetPlatform != stdenv.hostPlatform)
+                  "${stdenv.targetPlatform.config}-";
+
   crossConfigureFlags =
     # Ensure that -print-prog-name is able to find the correct programs.
     [
@@ -112,6 +115,18 @@ let
 
     # Basic configuration
     ++ [
+      # Force target prefix. The behavior if `--target` and `--host`
+      # are specified is inconsistent: Sometimes specifying `--target`
+      # always causes a prefix to be generated, sometimes it's only
+      # added if the `--host` and `--target` differ. This means that
+      # sometimes there may be a prefix even though nixpkgs doesn't
+      # expect one and sometimes there may be none even though nixpkgs
+      # expects one (since not all information is serialized into the
+      # config attribute). The easiest way out of these problems is to
+      # always set the program prefix, so gcc will conform to our
+      # expectations.
+      "--program-prefix=${targetPrefix}"
+
       (lib.enableFeature enableLTO "lto")
       "--disable-libstdcxx-pch"
       "--without-included-gettext"