diff --git a/pkgs/development/libraries/science/math/libhomfly/default.nix b/pkgs/development/libraries/science/math/libhomfly/default.nix
new file mode 100644
index 00000000000..e96ee475d7d
--- /dev/null
+++ b/pkgs/development/libraries/science/math/libhomfly/default.nix
@@ -0,0 +1,35 @@
+{ stdenv
+, fetchFromGitHub
+, autoreconfHook
+, boehmgc
+}:
+
+stdenv.mkDerivation rec {
+  version = "1.02r5";
+  name = "llibhomfly-${version}";
+
+  src = fetchFromGitHub {
+    owner = "miguelmarco";
+    repo = "libhomfly";
+    rev = version;
+    sha256 = "1szv8iwlhvmy3saigi15xz8vgch92p2lbsm6440v5s8vxj455bvd";
+  };
+
+  buildInputs = [
+    boehmgc
+  ];
+
+  nativeBuildInputs = [
+    autoreconfHook
+  ];
+
+  doCheck = true;
+
+  meta = with stdenv.lib; {
+    homepage = https://github.com/miguelmarco/libhomfly/;
+    description = "Library to compute the homfly polynomial of knots and links";
+    license = licenses.unlicense;
+    maintainers = with maintainers; [ timokau ];
+    platforms = platforms.all;
+  };
+}
diff --git a/pkgs/top-level/all-packages.nix b/pkgs/top-level/all-packages.nix
index a8eb4aadce6..701d72d7072 100644
--- a/pkgs/top-level/all-packages.nix
+++ b/pkgs/top-level/all-packages.nix
@@ -20502,6 +20502,8 @@ with pkgs;
 
   libbraiding = callPackage ../development/libraries/science/math/libbraiding { };
 
+  libhomfly = callPackage ../development/libraries/science/math/libhomfly { };
+
   # We have essentially 4 permutations of liblapack: version 3.4.1 or 3.5.0,
   # and with or without atlas as a dependency. The default `liblapack` is 3.4.1
   # with atlas. Atlas, when built with liblapack as a dependency, uses 3.5.0