diff --git a/pkgs/development/web/nodejs/disable-darwin-v8-system-instrumentation.patch b/pkgs/development/web/nodejs/disable-darwin-v8-system-instrumentation.patch
new file mode 100644
index 00000000000..63e9107b33d
--- /dev/null
+++ b/pkgs/development/web/nodejs/disable-darwin-v8-system-instrumentation.patch
@@ -0,0 +1,16 @@
+Disable v8 system instrumentation on Darwin
+
+On Darwin, the v8 system instrumentation requires the header "os/signpost.h"
+which is available since apple_sdk 11+. See: https://github.com/nodejs/node/issues/39584
+
+--- old/tools/v8_gypfiles/features.gypi
++++ new/tools/v8_gypfiles/features.gypi
+@@ -62,7 +62,7 @@
+       }, {
+         'is_component_build': 0,
+       }],
+-      ['OS == "win" or OS == "mac"', {
++      ['OS == "win"', {
+         # Sets -DSYSTEM_INSTRUMENTATION. Enables OS-dependent event tracing
+         'v8_enable_system_instrumentation': 1,
+       }, {
diff --git a/pkgs/development/web/nodejs/v12.nix b/pkgs/development/web/nodejs/v12.nix
index 66cf2e4904d..7717dfa6c9c 100644
--- a/pkgs/development/web/nodejs/v12.nix
+++ b/pkgs/development/web/nodejs/v12.nix
@@ -8,7 +8,7 @@ let
 in
   buildNodejs {
     inherit enableNpm;
-    version = "12.22.4";
-    sha256 = "0k6dwkhpmjcdb71zd92a5v0l82rsk06p57iyjby84lhy2fmlxka4";
+    version = "12.22.6";
+    sha256 = "0yhgkcp7lx5nglxsrybbjymx1fys3wkbbhkj6h6652gnp0b2y0n2";
     patches = lib.optional stdenv.isDarwin ./bypass-xcodebuild.diff;
   }
diff --git a/pkgs/development/web/nodejs/v14.nix b/pkgs/development/web/nodejs/v14.nix
index 3b04f751b48..1ec04407f89 100644
--- a/pkgs/development/web/nodejs/v14.nix
+++ b/pkgs/development/web/nodejs/v14.nix
@@ -7,7 +7,7 @@ let
 in
   buildNodejs {
     inherit enableNpm;
-    version = "14.17.4";
-    sha256 = "0b6gadc53r07gx6qr6281ifr5m9bgprmfdqyz9zh5j7qhkkz8yxf";
+    version = "14.17.6";
+    sha256 = "0pmd0haav2ychhcsw44klx6wfn8c7j1rsw08rc8hcm5i3h5wsn7l";
     patches = lib.optional stdenv.isDarwin ./bypass-xcodebuild.diff;
   }
diff --git a/pkgs/development/web/nodejs/v16.nix b/pkgs/development/web/nodejs/v16.nix
index 305baadecac..805e62be8d6 100644
--- a/pkgs/development/web/nodejs/v16.nix
+++ b/pkgs/development/web/nodejs/v16.nix
@@ -8,6 +8,7 @@ let
 in
   buildNodejs {
     inherit enableNpm;
-    version = "16.4.1";
-    sha256 = "1a1aygksmbafxvrs8g2jv0y1jj3cwyclk0qbqxkn5qfq5r1i943n";
+    version = "16.8.0";
+    sha256 = "14k3njj382im3q4k6dhsxdk07gs81hw2k0nrixfvlw1964k04ydq";
+    patches = [ ./disable-darwin-v8-system-instrumentation.patch ];
   }