diff --git a/pkgs/development/interpreters/python/cpython/2.7/default.nix b/pkgs/development/interpreters/python/cpython/2.7/default.nix
index 5842f6fb309..15b21b5bed9 100644
--- a/pkgs/development/interpreters/python/cpython/2.7/default.nix
+++ b/pkgs/development/interpreters/python/cpython/2.7/default.nix
@@ -6,7 +6,7 @@
 , openssl
 , readline
 , sqlite
-, tcl ? null, tk ? null, xlibsWrapper ? null, libX11 ? null, x11Support ? false
+, tcl ? null, tk ? null, tix ? null, xlibsWrapper ? null, libX11 ? null, x11Support ? false
 , zlib
 , callPackage
 , self
@@ -150,6 +150,10 @@ in stdenv.mkDerivation {
 
     setupHook = ./setup-hook.sh;
 
+    postPatch = optionalString (x11Support && (tix != null)) ''
+          substituteInPlace "Lib/lib-tk/Tix.py" --replace "os.environ.get('TIX_LIBRARY')" "os.environ.get('TIX_LIBRARY') or '${tix}/lib'"
+    '';
+
     postInstall =
       ''
         # needed for some packages, especially packages that backport
diff --git a/pkgs/development/interpreters/python/cpython/3.3/default.nix b/pkgs/development/interpreters/python/cpython/3.3/default.nix
index 6a543a8a0ee..3ab0de96704 100644
--- a/pkgs/development/interpreters/python/cpython/3.3/default.nix
+++ b/pkgs/development/interpreters/python/cpython/3.3/default.nix
@@ -6,7 +6,7 @@
 , openssl
 , readline
 , sqlite
-, tcl ? null, tk ? null, libX11 ? null, xproto ? null, x11Support ? false
+, tcl ? null, tk ? null, tix ? null, libX11 ? null, xproto ? null, x11Support ? false
 , zlib
 , callPackage
 , self
@@ -50,6 +50,10 @@ in stdenv.mkDerivation {
 
   NIX_LDFLAGS = stdenv.lib.optionalString stdenv.isLinux "-lgcc_s";
 
+  postPatch = optionalString (x11Support && (tix != null)) ''
+    substituteInPlace "Lib/tkinter/tix.py" --replace "os.environ.get('TIX_LIBRARY')" "os.environ.get('TIX_LIBRARY') or '${tix}/lib'"
+  '';
+
   preConfigure = ''
     for i in /usr /sw /opt /pkg; do	# improve purity
       substituteInPlace ./setup.py --replace $i /no-such-path
diff --git a/pkgs/development/interpreters/python/cpython/3.4/default.nix b/pkgs/development/interpreters/python/cpython/3.4/default.nix
index 623fa5d74f6..e081a60c6bc 100644
--- a/pkgs/development/interpreters/python/cpython/3.4/default.nix
+++ b/pkgs/development/interpreters/python/cpython/3.4/default.nix
@@ -6,7 +6,7 @@
 , openssl
 , readline
 , sqlite
-, tcl ? null, tk ? null, libX11 ? null, xproto ? null, x11Support ? false
+, tcl ? null, tk ? null, tix ? null, libX11 ? null, xproto ? null, x11Support ? false
 , zlib
 , callPackage
 , self
@@ -55,6 +55,10 @@ in stdenv.mkDerivation {
     substituteInPlace configure --replace '-Wl,-stack_size,1000000' ' '
   '';
 
+  postPatch = optionalString (x11Support && (tix != null)) ''
+    substituteInPlace "Lib/tkinter/tix.py" --replace "os.environ.get('TIX_LIBRARY')" "os.environ.get('TIX_LIBRARY') or '${tix}/lib'"
+  '';
+
   preConfigure = ''
     for i in /usr /sw /opt /pkg; do	# improve purity
       substituteInPlace ./setup.py --replace $i /no-such-path
diff --git a/pkgs/development/interpreters/python/cpython/3.5/default.nix b/pkgs/development/interpreters/python/cpython/3.5/default.nix
index 7172e429f23..92f9d66ea52 100644
--- a/pkgs/development/interpreters/python/cpython/3.5/default.nix
+++ b/pkgs/development/interpreters/python/cpython/3.5/default.nix
@@ -6,7 +6,7 @@
 , openssl
 , readline
 , sqlite
-, tcl ? null, tk ? null, libX11 ? null, xproto ? null, x11Support ? false
+, tcl ? null, tk ? null, tix ? null, libX11 ? null, xproto ? null, x11Support ? false
 , zlib
 , callPackage
 , self
@@ -55,6 +55,10 @@ in stdenv.mkDerivation {
     substituteInPlace configure --replace '-Wl,-stack_size,1000000' ' '
   '';
 
+  postPatch = optionalString (x11Support && (tix != null)) ''
+    substituteInPlace "Lib/tkinter/tix.py" --replace "os.environ.get('TIX_LIBRARY')" "os.environ.get('TIX_LIBRARY') or '${tix}/lib'"
+  '';
+
   preConfigure = ''
     for i in /usr /sw /opt /pkg; do	# improve purity
       substituteInPlace ./setup.py --replace $i /no-such-path
diff --git a/pkgs/development/interpreters/python/cpython/3.6/default.nix b/pkgs/development/interpreters/python/cpython/3.6/default.nix
index 8892b0f5c71..795bd746725 100644
--- a/pkgs/development/interpreters/python/cpython/3.6/default.nix
+++ b/pkgs/development/interpreters/python/cpython/3.6/default.nix
@@ -7,7 +7,7 @@
 , openssl
 , readline
 , sqlite
-, tcl ? null, tk ? null, libX11 ? null, xproto ? null, x11Support ? false
+, tcl ? null, tk ? null, tix ? null, libX11 ? null, xproto ? null, x11Support ? false
 , zlib
 , callPackage
 , self
@@ -55,6 +55,10 @@ in stdenv.mkDerivation {
     substituteInPlace configure --replace '-Wl,-stack_size,1000000' ' '
   '';
 
+  postPatch = optionalString (x11Support && (tix != null)) ''
+    substituteInPlace "Lib/tkinter/tix.py" --replace "os.environ.get('TIX_LIBRARY')" "os.environ.get('TIX_LIBRARY') or '${tix}/lib'"
+  '';
+
   preConfigure = ''
     for i in /usr /sw /opt /pkg; do	# improve purity
       substituteInPlace ./setup.py --replace $i /no-such-path
diff --git a/pkgs/development/interpreters/python/pypy/2.7/default.nix b/pkgs/development/interpreters/python/pypy/2.7/default.nix
index 1fd9eaee430..1cc2f95791f 100644
--- a/pkgs/development/interpreters/python/pypy/2.7/default.nix
+++ b/pkgs/development/interpreters/python/pypy/2.7/default.nix
@@ -1,5 +1,5 @@
 { stdenv, fetchurl, zlib ? null, zlibSupport ? true, bzip2, pkgconfig, libffi
-, sqlite, openssl, ncurses, python, expat, tcl, tk, xlibsWrapper, libX11
+, sqlite, openssl, ncurses, python, expat, tcl, tk, tix, xlibsWrapper, libX11
 , makeWrapper, callPackage, self, gdbm, db
 # For the Python package set
 , pkgs, packageOverrides ? (self: super: {})
@@ -35,6 +35,7 @@ let
       };
       in ''
       patch lib-python/2.7/test/test_pyexpat.py < '${expatch}'
+      substituteInPlace "lib-python/2.7/lib-tk/Tix.py" --replace "os.environ.get('TIX_LIBRARY')" "os.environ.get('TIX_LIBRARY') or '${tix}/lib'"
     '';
 
     buildInputs = [ bzip2 openssl pkgconfig python libffi ncurses expat sqlite tk tcl xlibsWrapper libX11 makeWrapper gdbm db ]