diff --git a/pkgs/development/python-modules/wxPython/4.0.nix b/pkgs/development/python-modules/wxPython/4.0.nix
index 406493362c4..a1cee317e34 100644
--- a/pkgs/development/python-modules/wxPython/4.0.nix
+++ b/pkgs/development/python-modules/wxPython/4.0.nix
@@ -9,10 +9,18 @@
 , python
 , doxygen
 , ncurses
-, wxGTK
+, libintl
 , numpy
 , pillow
 , six
+, wxGTK
+, wxmac
+, IOKit
+, Carbon
+, Cocoa
+, AudioToolbox
+, OpenGL
+, CoreFoundation
 }:
 
 buildPythonPackage rec {
@@ -26,8 +34,16 @@ buildPythonPackage rec {
 
   doCheck = false;
 
-  nativeBuildInputs = [ pkgconfig which doxygen wxGTK ];
-  buildInputs = [ ncurses wxGTK.gtk ];
+  nativeBuildInputs = [ pkgconfig which doxygen ]
+  ++ (if stdenv.isDarwin then [ wxmac ] else [ wxGTK ]);
+
+  buildInputs = [ ncurses libintl ]
+  ++ (if stdenv.isDarwin
+  then
+    [ AudioToolbox Carbon Cocoa CoreFoundation IOKit OpenGL ]
+  else
+    [ wxGTK.gtk ]
+  );
 
   DOXYGEN = "${doxygen}/bin/doxygen";
 
@@ -50,7 +66,7 @@ buildPythonPackage rec {
     ${python.interpreter} setup.py install --skip-build --prefix=$out
   '';
 
-  passthru = { inherit wxGTK; };
+  passthru = { wxWidgets = if stdenv.isDarwin then wxmac else wxGTK; };
 
 
   meta = {
diff --git a/pkgs/top-level/python-packages.nix b/pkgs/top-level/python-packages.nix
index 4fc535f60f4..e6fdcace951 100644
--- a/pkgs/top-level/python-packages.nix
+++ b/pkgs/top-level/python-packages.nix
@@ -8121,6 +8121,7 @@ in {
 
   wxPython_4_0 = callPackage ../development/python-modules/wxPython/4.0.nix {
     inherit (pkgs) pkgconfig;
+    inherit (pkgs.darwin.apple_sdk.frameworks) AudioToolbox Carbon Cocoa CoreFoundation IOKit OpenGL;
     wxGTK = pkgs.wxGTK30.override {
       withGtk2 = false;
       withWebKit = true;