diff --git a/pkgs/development/python-modules/generic/catch_conflicts.py b/pkgs/development/python-modules/generic/catch_conflicts.py
index 35512bb44d3..bb82900c65a 100644
--- a/pkgs/development/python-modules/generic/catch_conflicts.py
+++ b/pkgs/development/python-modules/generic/catch_conflicts.py
@@ -9,7 +9,7 @@ for f in sys.path:
     for req in pkg_resources.find_distributions(f):
         if req not in packages[req.project_name]:
             # some exceptions inside buildPythonPackage
-            if req.project_name in ['setuptools', 'pip']:
+            if req.project_name in ['setuptools', 'pip', 'wheel']:
                 continue
             packages[req.project_name].append(req)
 
diff --git a/pkgs/top-level/python-packages.nix b/pkgs/top-level/python-packages.nix
index 8da5f111b7c..176a975d5bf 100644
--- a/pkgs/top-level/python-packages.nix
+++ b/pkgs/top-level/python-packages.nix
@@ -23607,6 +23607,9 @@ in modules // {
 
     propagatedBuildInputs = with self; [ jsonschema ];
 
+    # We add this flag to ignore the copy installed by bootstrapped-pip
+    installFlags = [ "--ignore-installed" ];
+
     meta = {
       description = "A built-package format for Python";
       license = with licenses; [ mit ];