diff --git a/pkgs/applications/science/biology/bowtie2/default.nix b/pkgs/applications/science/biology/bowtie2/default.nix
index 715f5bb8bfa..4f5872de07d 100644
--- a/pkgs/applications/science/biology/bowtie2/default.nix
+++ b/pkgs/applications/science/biology/bowtie2/default.nix
@@ -2,13 +2,13 @@
 
 stdenv.mkDerivation rec {
   pname = "bowtie2";
-  version = "2.4.2";
+  version = "2.4.3";
 
   src = fetchFromGitHub {
     owner = "BenLangmead";
     repo = pname;
     rev = "v${version}";
-    sha256 = "11apzq7l1lk3yxw97g9dfr0gwnvfh58x6apifcblgd66gbip3y1y";
+    sha256 = "sha256-uEKTB8935YY6lpXv2tJBQ1hrRk63vALLQb6SUXsVyhQ=";
   };
 
   nativeBuildInputs = [ cmake ];