diff --git a/nixos/modules/services/web-apps/nextcloud.nix b/nixos/modules/services/web-apps/nextcloud.nix
index 4bfa564a67f..4352e0e1c0f 100644
--- a/nixos/modules/services/web-apps/nextcloud.nix
+++ b/nixos/modules/services/web-apps/nextcloud.nix
@@ -407,40 +407,13 @@ in {
             The package can be upgraded by explicitly declaring the service-option
             `services.nextcloud.package`.
           '';
-
-        # FIXME(@Ma27) remove as soon as nextcloud properly supports
-        # mariadb >=10.6.
-        isUnsupportedMariadb =
-          # All currently supported Nextcloud versions are affected.
-          (versionOlder cfg.package.version "23")
-          # This module uses mysql
-          && (cfg.config.dbtype == "mysql")
-          # MySQL is managed via NixOS
-          && config.services.mysql.enable
-          # We're using MariaDB
-          && (getName config.services.mysql.package) == "mariadb-server"
-          # MariaDB is at least 10.6 and thus not supported
-          && (versionAtLeast (getVersion config.services.mysql.package) "10.6");
-
       in (optional (cfg.poolConfig != null) ''
           Using config.services.nextcloud.poolConfig is deprecated and will become unsupported in a future release.
           Please migrate your configuration to config.services.nextcloud.poolSettings.
         '')
         ++ (optional (versionOlder cfg.package.version "19") (upgradeWarning 18 "20.09"))
         ++ (optional (versionOlder cfg.package.version "20") (upgradeWarning 19 "21.05"))
-        ++ (optional (versionOlder cfg.package.version "21") (upgradeWarning 20 "21.05"))
-        ++ (optional (versionOlder cfg.package.version "22") (upgradeWarning 21 "21.11"))
-        ++ (optional isUnsupportedMariadb ''
-            You seem to be using MariaDB at an unsupported version (i.e. at least 10.6)!
-            Please note that this isn't supported officially by Nextcloud. You can either
-
-            * Switch to `pkgs.mysql`
-            * Downgrade MariaDB to at least 10.5
-            * Work around Nextcloud's problems by specifying `innodb_read_only_compressed=0`
-
-            For further context, please read
-            https://help.nextcloud.com/t/update-to-next-cloud-21-0-2-has-get-an-error/117028/15
-          '');
+        ++ (optional (versionOlder cfg.package.version "21") (upgradeWarning 20 "21.05"));
 
       services.nextcloud.package = with pkgs;
         mkDefault (
diff --git a/nixos/tests/nextcloud/with-mysql-and-memcached.nix b/nixos/tests/nextcloud/with-mysql-and-memcached.nix
index c0df773eaaa..639a3f4c873 100644
--- a/nixos/tests/nextcloud/with-mysql-and-memcached.nix
+++ b/nixos/tests/nextcloud/with-mysql-and-memcached.nix
@@ -42,13 +42,6 @@ in {
         enable = true;
         bind = "127.0.0.1";
         package = pkgs.mariadb;
-
-        # FIXME(@Ma27) Nextcloud isn't compatible with mariadb 10.6,
-        # this is a workaround.
-        # See https://help.nextcloud.com/t/update-to-next-cloud-21-0-2-has-get-an-error/117028/22
-        extraOptions = ''
-          innodb_read_only_compressed=0
-        '';
         initialScript = pkgs.writeText "mysql-init" ''
           CREATE USER 'nextcloud'@'localhost' IDENTIFIED BY 'hunter2';
           CREATE DATABASE IF NOT EXISTS nextcloud;