diff --git a/pkgs/applications/science/misc/root/default.nix b/pkgs/applications/science/misc/root/default.nix
index 97d8d4e7cee..03b20697310 100644
--- a/pkgs/applications/science/misc/root/default.nix
+++ b/pkgs/applications/science/misc/root/default.nix
@@ -1,19 +1,20 @@
-{ stdenv, lib, fetchurl, makeWrapper, cmake, gl2ps, gsl, libX11, libXpm, libXft
-, libXext, libGLU, libGL, libxml2, lz4, lzma, pcre, pkgconfig, python, xxHash
-, zlib
+{ stdenv, lib, fetchurl, makeWrapper, cmake, ftgl, gl2ps, glew, gsl, llvm_5
+, libX11, libXpm, libXft, libXext, libGLU, libGL, libxml2, lz4, lzma, pcre
+, pkgconfig, python, xxHash, zlib, zstd
+, libAfterImage, giflib, libjpeg, libtiff, libpng
 , Cocoa, OpenGL, noSplash ? false }:
 
 stdenv.mkDerivation rec {
   pname = "root";
-  version = "6.18.04";
+  version = "6.22.06";
 
   src = fetchurl {
     url = "https://root.cern.ch/download/root_v${version}.source.tar.gz";
-    sha256 = "196ghma6g5a7sqz52wyjkgvmh4hj4vqwppm0zwdypy33hgy8anii";
+    sha256 = "0mqvj42nax0bmz8h83jjlwjm3xxjy1n0n10inc8csip9ly28fs64";
   };
 
   nativeBuildInputs = [ makeWrapper cmake pkgconfig ];
-  buildInputs = [ gl2ps pcre zlib libxml2 lz4 lzma gsl xxHash python.pkgs.numpy ]
+  buildInputs = [ ftgl gl2ps glew pcre zlib zstd llvm_5 libxml2 lz4 lzma gsl xxHash libAfterImage giflib libjpeg libtiff libpng python.pkgs.numpy ]
     ++ lib.optionals (!stdenv.isDarwin) [ libX11 libXpm libXft libXext libGLU libGL ]
     ++ lib.optionals (stdenv.isDarwin) [ Cocoa OpenGL ]
     ;
@@ -38,6 +39,7 @@ stdenv.mkDerivation rec {
     "-DCMAKE_INSTALL_INCLUDEDIR=include"
     "-Dalien=OFF"
     "-Dbonjour=OFF"
+    "-Dbuiltin_llvm=OFF"
     "-Dcastor=OFF"
     "-Dchirp=OFF"
     "-Dclad=OFF"
@@ -69,7 +71,14 @@ stdenv.mkDerivation rec {
     "-Dxrootd=OFF"
   ]
   ++ stdenv.lib.optional (stdenv.cc.libc != null) "-DC_INCLUDE_DIRS=${stdenv.lib.getDev stdenv.cc.libc}/include"
-  ++ stdenv.lib.optional stdenv.isDarwin "-DOPENGL_INCLUDE_DIR=${OpenGL}/Library/Frameworks";
+  ++ stdenv.lib.optionals stdenv.isDarwin [
+    "-DOPENGL_INCLUDE_DIR=${OpenGL}/Library/Frameworks"
+    "-DCMAKE_DISABLE_FIND_PACKAGE_Python2=TRUE"
+
+    # fatal error: module map file '/nix/store/<hash>-Libsystem-osx-10.12.6/include/module.modulemap' not found
+    # fatal error: could not build module '_Builtin_intrinsics'
+    "-Druntime_cxxmodules=OFF"
+  ];
 
   enableParallelBuilding = true;
 
diff --git a/pkgs/applications/science/misc/root/sw_vers.patch b/pkgs/applications/science/misc/root/sw_vers.patch
index 34af132c11f..b2ee1b6a4ce 100644
--- a/pkgs/applications/science/misc/root/sw_vers.patch
+++ b/pkgs/applications/science/misc/root/sw_vers.patch
@@ -1,19 +1,7 @@
-diff a/build/unix/compiledata.sh b/build/unix/compiledata.sh
---- a/build/unix/compiledata.sh
-+++ b/build/unix/compiledata.sh
-@@ -47,7 +47,7 @@ fi
- 
- if [ "$ARCH" = "macosx" ] || [ "$ARCH" = "macosx64" ] || \
-    [ "$ARCH" = "macosxicc" ]; then
--   macosx_minor=`sw_vers | sed -n 's/ProductVersion://p' | cut -d . -f 2`
-+   macosx_minor=12
-    SOEXT="so"
-    if [ $macosx_minor -ge 5 ]; then
-       if [ "x`echo $SOFLAGS | grep -- '-install_name'`" != "x" ]; then
 diff a/cmake/modules/SetUpMacOS.cmake b/cmake/modules/SetUpMacOS.cmake
 --- a/cmake/modules/SetUpMacOS.cmake
 +++ b/cmake/modules/SetUpMacOS.cmake
-@@ -2,17 +2,8 @@ set(ROOT_ARCHITECTURE macosx)
+@@ -8,17 +8,10 @@ set(ROOT_ARCHITECTURE macosx)
  set(ROOT_PLATFORM macosx)
  
  if (CMAKE_SYSTEM_NAME MATCHES Darwin)
@@ -21,8 +9,8 @@ diff a/cmake/modules/SetUpMacOS.cmake b/cmake/modules/SetUpMacOS.cmake
 -                  COMMAND cut -d . -f 1-2
 -                  OUTPUT_VARIABLE MACOSX_VERSION OUTPUT_STRIP_TRAILING_WHITESPACE)
 -
--  MESSAGE(STATUS "Found a Mac OS X System ${MACOSX_VERSION}")
--
+   MESSAGE(STATUS "Found a macOS system ${MACOSX_VERSION}")
+ 
 -  if(MACOSX_VERSION VERSION_GREATER 10.7 AND ${CMAKE_CXX_COMPILER_ID} MATCHES Clang)
      set(libcxx ON CACHE BOOL "Build using libc++" FORCE)
 -  endif()
@@ -31,7 +19,7 @@ diff a/cmake/modules/SetUpMacOS.cmake b/cmake/modules/SetUpMacOS.cmake
      #TODO: check haveconfig and rpath -> set rpath true
      #TODO: check Thread, define link command
      #TODO: more stuff check configure script
-@@ -25,23 +16,7 @@ if (CMAKE_SYSTEM_NAME MATCHES Darwin)
+@@ -37,23 +30,7 @@ if (CMAKE_SYSTEM_NAME MATCHES Darwin)
         SET(CMAKE_CXX_FLAGS "${CMAKE_CXX_FLAGS} -m64")
         SET(CMAKE_C_FLAGS "${CMAKE_C_FLAGS} -m64")
         SET(CMAKE_Fortran_FLAGS "${CMAKE_Fortran_FLAGS} -m64")
@@ -56,7 +44,7 @@ diff a/cmake/modules/SetUpMacOS.cmake b/cmake/modules/SetUpMacOS.cmake
  
    if (CMAKE_COMPILER_IS_GNUCXX)
       message(STATUS "Found GNU compiler collection")
-@@ -104,7 +79,6 @@ if (CMAKE_SYSTEM_NAME MATCHES Darwin)
+@@ -115,7 +92,6 @@ if (CMAKE_SYSTEM_NAME MATCHES Darwin)
    endif()
  
    #---Set Linker flags----------------------------------------------------------------------
@@ -67,33 +55,33 @@ diff a/cmake/modules/SetUpMacOS.cmake b/cmake/modules/SetUpMacOS.cmake
 diff a/config/root-config.in b/config/root-config.in
 --- a/config/root-config.in
 +++ b/config/root-config.in
-@@ -306,12 +306,6 @@ macosxicc)
-    auxlibs="-lm -ldl"
+@@ -312,12 +312,6 @@ macosxicc)
     ;;
- macosx64)
--   # MacOS X with gcc (GNU cc v4.x) in 64 bit mode
+ macosx64|macosxarm64)
+    # MacOS X with gcc (GNU cc v4.x) in 64 bit mode
+-   macosx_major=`sw_vers | sed -n 's/ProductVersion://p' | cut -d . -f 1 | sed -e 's/^[[:space:]]*//'`
 -   macosx_minor=`sw_vers | sed -n 's/ProductVersion://p' | cut -d . -f 2`
 -   # cannot find the one linked to libGraf if relocated after built
--   if [ $macosx_minor -le 4 ]; then
+-   if [ $macosx_major -eq 10 -a $macosx_minor -le 4 ]; then
 -      rootlibs="$rootlibs -lfreetype"
 -   fi
     auxcflags="${cxxversionflag} -m64"
     auxldflags="-m64"
     auxlibs="-lm -ldl"
-@@ -375,18 +369,11 @@ freebsd* | openbsd* | linux*)
+@@ -378,18 +372,11 @@ freebsd* | openbsd* | linux*)
+    done
+    ;;
  macosx*)
+-   if [ \( $macosx_major -eq 10 -a $macosx_minor -ge 5 \) -o $macosx_major -gt 10  ]; then
+       auxcflags="-pthread $auxcflags"
+       auxlibs="-lpthread $auxlibs"
+-   else
+-      auxcflags="-D_REENTRANT $auxcflags"
+-      auxlibs="-lpthread $auxlibs"
+-   fi
     for f in $features ; do
-       if test "x$f" = "xthread" ; then
--         if [ $macosx_minor -ge 5 ]; then
-             auxcflags="-pthread $auxcflags"
-             auxlibs="-lpthread $auxlibs"
--         else
--            auxcflags="-D_REENTRANT $auxcflags"
--            auxlibs="-lpthread $auxlibs"
--         fi
-       fi
        if test "x$f" = "xrpath" ; then
--         if [ $macosx_minor -ge 5 ]; then
+-         if [ \( $macosx_major -eq 10 -a $macosx_minor -ge 5 \) -o $macosx_major -gt 10  ]; then
              auxlibs="-Wl,-rpath,$libdir $auxlibs"
 -         fi
        fi
diff --git a/pkgs/development/libraries/glew/1.10.nix b/pkgs/development/libraries/glew/1.10.nix
index 02737143e0d..139b93c039e 100644
--- a/pkgs/development/libraries/glew/1.10.nix
+++ b/pkgs/development/libraries/glew/1.10.nix
@@ -1,5 +1,5 @@
 { stdenv, fetchurl, libGLU, xlibsWrapper, libXmu, libXi
-, AGL ? null
+, AGL, OpenGL
 }:
 
 with stdenv.lib;
@@ -12,9 +12,8 @@ stdenv.mkDerivation rec {
     sha256 = "01zki46dr5khzlyywr3cg615bcal32dazfazkf360s1znqh17i4r";
   };
 
-  buildInputs = [ xlibsWrapper libXmu libXi ]
-              ++ optionals stdenv.isDarwin [ AGL ];
-  propagatedBuildInputs = [ libGLU ]; # GL/glew.h includes GL/glu.h
+  buildInputs = if stdenv.isDarwin then [ AGL ] else [ xlibsWrapper libXmu libXi ];
+  propagatedBuildInputs = if stdenv.isDarwin then [ OpenGL ] else [ libGLU ]; # GL/glew.h includes GL/glu.h
 
   patchPhase = ''
     sed -i 's|lib64|lib|' config/Makefile.linux
diff --git a/pkgs/development/libraries/glew/default.nix b/pkgs/development/libraries/glew/default.nix
index 80a7759c574..3b067e6d0f3 100644
--- a/pkgs/development/libraries/glew/default.nix
+++ b/pkgs/development/libraries/glew/default.nix
@@ -1,4 +1,5 @@
 { stdenv, fetchurl, libGLU, xlibsWrapper, libXmu, libXi
+, OpenGL
 }:
 
 with stdenv.lib;
@@ -13,8 +14,8 @@ stdenv.mkDerivation rec {
 
   outputs = [ "bin" "out" "dev" "doc" ];
 
-  buildInputs = [ xlibsWrapper libXmu libXi ];
-  propagatedBuildInputs = [ libGLU ]; # GL/glew.h includes GL/glu.h
+  buildInputs = optionals (!stdenv.isDarwin) [ xlibsWrapper libXmu libXi ];
+  propagatedBuildInputs = if stdenv.isDarwin then [ OpenGL ] else [ libGLU ]; # GL/glew.h includes GL/glu.h
 
   patchPhase = ''
     sed -i 's|lib64|lib|' config/Makefile.linux
diff --git a/pkgs/development/libraries/libAfterImage/default.nix b/pkgs/development/libraries/libAfterImage/default.nix
new file mode 100644
index 00000000000..8936603d18b
--- /dev/null
+++ b/pkgs/development/libraries/libAfterImage/default.nix
@@ -0,0 +1,25 @@
+{ stdenv, fetchurl, zlib }:
+
+stdenv.mkDerivation {
+  pname = "libAfterImage";
+  version = "1.20";
+
+  src = fetchurl {
+    name = "libAfterImage-1.20.tar.bz2";
+    urls = [
+      "https://sourceforge.net/projects/afterstep/files/libAfterImage/1.20/libAfterImage-1.20.tar.bz2/download"
+      "ftp://ftp.afterstep.org/stable/libAfterImage/libAfterImage-1.20.tar.bz2"
+    ];
+    sha256 = "0n74rxidwig3yhr6fzxsk7y19n1nq1f296lzrvgj5pfiyi9k48vf";
+  };
+
+  buildInputs = [ zlib ];
+
+  meta = with stdenv.lib; {
+    homepage = "http://www.afterstep.org/afterimage/";
+    description = "A generic image manipulation library";
+    platforms = platforms.unix;
+    maintainers = [ maintainers.veprbl ];
+    license = licenses.lgpl21;
+  };
+}
diff --git a/pkgs/development/libraries/physics/yoda/default.nix b/pkgs/development/libraries/physics/yoda/default.nix
index 3a8fbbbdd52..39bffb65237 100644
--- a/pkgs/development/libraries/physics/yoda/default.nix
+++ b/pkgs/development/libraries/physics/yoda/default.nix
@@ -39,5 +39,7 @@ stdenv.mkDerivation rec {
     homepage    = "https://yoda.hepforge.org";
     platforms   = stdenv.lib.platforms.unix;
     maintainers = with stdenv.lib.maintainers; [ veprbl ];
+    # https://gitlab.com/hepcedar/yoda/-/issues/24
+    broken      = withRootSupport;
   };
 }
diff --git a/pkgs/top-level/all-packages.nix b/pkgs/top-level/all-packages.nix
index d0dc0a69fad..d698a901236 100644
--- a/pkgs/top-level/all-packages.nix
+++ b/pkgs/top-level/all-packages.nix
@@ -13153,9 +13153,11 @@ in
 
   gle = callPackage ../development/libraries/gle { };
 
-  glew = callPackage ../development/libraries/glew { };
+  glew = callPackage ../development/libraries/glew {
+    inherit (darwin.apple_sdk.frameworks) OpenGL;
+  };
   glew110 = callPackage ../development/libraries/glew/1.10.nix {
-    inherit (darwin.apple_sdk.frameworks) AGL;
+    inherit (darwin.apple_sdk.frameworks) AGL OpenGL;
   };
 
   glfw = glfw3;
@@ -13820,6 +13822,8 @@ in
 
   lib3mf = callPackage ../development/libraries/lib3mf { };
 
+  libAfterImage = callPackage ../development/libraries/libAfterImage { };
+
   libaacs = callPackage ../development/libraries/libaacs { };
 
   libaal = callPackage ../development/libraries/libaal { };