diff --git a/pkgs/development/interpreters/python/hooks/pytest-check-hook.sh b/pkgs/development/interpreters/python/hooks/pytest-check-hook.sh
index 18f05b6d218..bfd2bfa7583 100644
--- a/pkgs/development/interpreters/python/hooks/pytest-check-hook.sh
+++ b/pkgs/development/interpreters/python/hooks/pytest-check-hook.sh
@@ -46,4 +46,16 @@ function pytestCheckPhase() {
 if [ -z "${dontUsePytestCheck-}" ] && [ -z "${installCheckPhase-}" ]; then
     echo "Using pytestCheckPhase"
     preDistPhases+=" pytestCheckPhase"
+
+    # It's almost always the case that setuptoolsCheckPhase should not be ran
+    # when the pytestCheckHook is being ran
+    if [ -z "${useSetuptoolsCheck-}" ]; then
+        dontUseSetuptoolsCheck=1
+
+        # Remove command if already injected into preDistPhases
+        if [[ "$preDistPhases" =~ "setuptoolsCheckPhase" ]]; then
+            echo "Removing setuptoolsCheckPhase"
+            preDistPhases=${preDistPhases/setuptoolsCheckPhase/}
+        fi
+    fi
 fi