diff --git a/pkgs/tools/X11/xpra/default.nix b/pkgs/tools/X11/xpra/default.nix
index 863c02fb23d..ffede7d58b2 100644
--- a/pkgs/tools/X11/xpra/default.nix
+++ b/pkgs/tools/X11/xpra/default.nix
@@ -14,11 +14,11 @@ let
   xf86videodummy = callPackage ./xf86videodummy { };
 in buildPythonApplication rec {
   pname = "xpra";
-  version = "2.5";
+  version = "2.5.3";
 
   src = fetchurl {
     url = "https://xpra.org/src/${pname}-${version}.tar.xz";
-    sha256 = "0q6c7ijgpp2wk6jlh0pzqki1w60i36wyl2zfwkg0gpdh40ypab3x";
+    sha256 = "1ys35lj28903alccks9p055psy1fsk1nxi8ncchvw8bfxkkkvbys";
   };
 
   patches = [
@@ -56,7 +56,7 @@ in buildPythonApplication rec {
   propagatedBuildInputs = with python3.pkgs; [
     pillow rencode pycrypto cryptography pycups lz4 dbus-python
     netifaces numpy pygobject3 pycairo gst-python pam
-    pyopengl paramiko opencv python-uinput pyxdg
+    pyopengl paramiko opencv4 python-uinput pyxdg
     ipaddress idna
   ];
 
diff --git a/pkgs/tools/X11/xpra/fix-paths.patch b/pkgs/tools/X11/xpra/fix-paths.patch
index ac8107235be..eb982682586 100644
--- a/pkgs/tools/X11/xpra/fix-paths.patch
+++ b/pkgs/tools/X11/xpra/fix-paths.patch
@@ -1,15 +1,8 @@
+gdiff --git a/setup.py b/setup.py
+index 8d3df15..6156206 100755
 --- a/setup.py
 +++ b/setup.py
-@@ -1885,7 +1885,7 @@
-     if OSX:
-         pycairo = "py3cairo"
-     else:
--        pycairo = "pycairo"
-+        pycairo = "py3cairo"
-     cython_add(Extension("xpra.client.gtk3.cairo_workaround",
-                 ["xpra/client/gtk3/cairo_workaround.pyx"],
-                 **pkgconfig(pycairo)
-@@ -2363,10 +2363,7 @@
+@@ -2359,10 +2359,7 @@ if v4l2_ENABLED:
      v4l2_pkgconfig = pkgconfig()
      #fuly warning: cython makes this difficult,
      #we have to figure out if "device_caps" exists in the headers:
@@ -21,14 +14,16 @@
      kwargs = {"ENABLE_DEVICE_CAPS" : ENABLE_DEVICE_CAPS}
      make_constants("xpra", "codecs", "v4l2", "constants", **kwargs)
      cython_add(Extension("xpra.codecs.v4l2.pusher",
+diff --git a/xpra/x11/bindings/keyboard_bindings.pyx b/xpra/x11/bindings/keyboard_bindings.pyx
+index bd7023d..064c6b5 100644
 --- a/xpra/x11/bindings/keyboard_bindings.pyx
 +++ b/xpra/x11/bindings/keyboard_bindings.pyx
-@@ -19,7 +19,7 @@
- 
+@@ -21,7 +21,7 @@ from libc.stdlib cimport free, malloc
+
  DEF PATH_MAX = 1024
  DEF DFLT_XKB_RULES_FILE = b"base"
 -DEF DFLT_XKB_CONFIG_ROOT = b"/usr/share/X11/xkb"
 +DEF DFLT_XKB_CONFIG_ROOT = b"@xkeyboardconfig@/share/X11/xkb"
- 
+
  ###################################
  # Headers, python magic