diff --git a/pkgs/desktops/gnome-2/desktop/gtksourceview/default.nix b/pkgs/desktops/gnome-2/desktop/gtksourceview/default.nix
index c69ee82fa26..7c9cd42a0e9 100644
--- a/pkgs/desktops/gnome-2/desktop/gtksourceview/default.nix
+++ b/pkgs/desktops/gnome-2/desktop/gtksourceview/default.nix
@@ -1,5 +1,8 @@
-{stdenv, fetchurl, pkgconfig, atk, cairo, glib, gtk, pango, 
-  libxml2Python, perl, intltool, gettext}:
+{stdenv, fetchpatch, fetchurl, autoreconfHook, pkgconfig, atk, cairo, glib
+, gnome_common, gtk, pango
+, libxml2Python, perl, intltool, gettext, gtk-mac-integration }:
+
+with stdenv.lib;
 
 stdenv.mkDerivation rec {
   name = "gtksourceview-${version}";
@@ -9,6 +12,29 @@ stdenv.mkDerivation rec {
     url = "mirror://gnome/sources/gtksourceview/2.10/${name}.tar.bz2";
     sha256 = "c585773743b1df8a04b1be7f7d90eecdf22681490d6810be54c81a7ae152191e";
   };
-  buildInputs = [pkgconfig atk cairo glib gtk pango libxml2Python perl intltool
-    gettext];
+
+  patches = optionals stdenv.isDarwin [
+    (fetchpatch {
+      name = "change-igemacintegration-to-gtkosxapplication.patch";
+      url = "https://git.gnome.org/browse/gtksourceview/patch/?id=e88357c5f210a8796104505c090fb6a04c213902";
+      sha256 = "0h5q79q9dqbg46zcyay71xn1pm4aji925gjd5j93v4wqn41wj5m7";
+    })
+    (fetchpatch {
+      name = "update-to-gtk-mac-integration-2.0-api.patch";
+      url = "https://git.gnome.org/browse/gtksourceview/patch/?id=ab46e552e1d0dae73f72adac8d578e40bdadaf95";
+      sha256 = "0qzrbv4hpa0v8qbmpi2vp575n13lkrvp3cgllwrd2pslw1v9q3aj";
+    })
+  ];
+
+  buildInputs = [
+    pkgconfig atk cairo glib gtk
+    pango libxml2Python perl intltool
+    gettext
+  ] ++ optionals stdenv.isDarwin [
+    autoreconfHook gnome_common gtk-mac-integration
+  ];
+
+  preConfigure = optionalString stdenv.isDarwin ''
+    intltoolize --force
+  '';
 }
diff --git a/pkgs/development/libraries/cairo/default.nix b/pkgs/development/libraries/cairo/default.nix
index 5d201c52312..5b40f27674d 100644
--- a/pkgs/development/libraries/cairo/default.nix
+++ b/pkgs/development/libraries/cairo/default.nix
@@ -47,7 +47,7 @@ stdenv.mkDerivation rec {
     libiconv
   ] ++ libintlOrEmpty ++ optionals stdenv.isDarwin (with darwin.apple_sdk.frameworks; [
     CoreGraphics
-    ApplicationServices
+    CoreText
     Carbon
   ]);
 
@@ -56,6 +56,9 @@ stdenv.mkDerivation rec {
     ++ optionals xcbSupport [ libxcb xcbutil ]
     ++ optional gobjectSupport glib
     ++ optional glSupport mesa_noglu
+    ++ optionals stdenv.isDarwin (with darwin.apple_sdk.frameworks; [
+      ApplicationServices
+    ])
     ; # TODO: maybe liblzo but what would it be for here?
 
   configureFlags = if stdenv.isDarwin then [
diff --git a/pkgs/development/libraries/gtk+/2.x.nix b/pkgs/development/libraries/gtk+/2.x.nix
index ba12b4eea93..bcbbecd242d 100644
--- a/pkgs/development/libraries/gtk+/2.x.nix
+++ b/pkgs/development/libraries/gtk+/2.x.nix
@@ -2,11 +2,15 @@
 , gdk_pixbuf, libintlOrEmpty, xlibsWrapper
 , xineramaSupport ? stdenv.isLinux
 , cupsSupport ? true, cups ? null
+, gdktarget ? "x11"
+, AppKit, Cocoa
 }:
 
 assert xineramaSupport -> xorg.libXinerama != null;
 assert cupsSupport -> cups != null;
 
+with stdenv.lib;
+
 stdenv.mkDerivation rec {
   name = "gtk+-2.24.31";
 
@@ -20,7 +24,7 @@ stdenv.mkDerivation rec {
 
   enableParallelBuilding = true;
 
-  NIX_CFLAGS_COMPILE = stdenv.lib.optionalString (libintlOrEmpty != []) "-lintl";
+  NIX_CFLAGS_COMPILE = optionalString (libintlOrEmpty != []) "-lintl";
 
   setupHook = ./setup-hook.sh;
 
@@ -28,7 +32,7 @@ stdenv.mkDerivation rec {
 
   patches = [ ./2.0-immodules.cache.patch ];
 
-  propagatedBuildInputs = with xorg; with stdenv.lib;
+  propagatedBuildInputs = with xorg;
     [ glib cairo pango gdk_pixbuf atk ]
     ++ optionals (stdenv.isLinux || stdenv.isDarwin) [
          libXrandr libXrender libXcomposite libXi libXcursor
@@ -36,11 +40,13 @@ stdenv.mkDerivation rec {
     ++ optionals stdenv.isDarwin [ xlibsWrapper libXdamage ]
     ++ libintlOrEmpty
     ++ optional xineramaSupport libXinerama
-    ++ optionals cupsSupport [ cups ];
+    ++ optionals cupsSupport [ cups ]
+    ++ optionals (gdktarget == "quartz") [ AppKit Cocoa ];
 
   configureFlags = [
+    "--with-gdktarget=${gdktarget}"
     "--with-xinput=yes"
-  ] ++ stdenv.lib.optionals stdenv.isDarwin [
+  ] ++ optionals stdenv.isDarwin [
     "--disable-glibtest"
     "--disable-introspection"
     "--disable-visibility"
@@ -57,9 +63,10 @@ stdenv.mkDerivation rec {
       rm $out/lib/gtk-2.0/2.10.0/immodules.cache
       $out/bin/gtk-query-immodules-2.0 $out/lib/gtk-2.0/2.10.0/immodules/*.so > $out/lib/gtk-2.0/2.10.0/immodules.cache
     ''; # workaround for bug of nix-mode for Emacs */ '';
+    inherit gdktarget;
   };
 
-  meta = with stdenv.lib; {
+  meta = {
     description = "A multi-platform toolkit for creating graphical user interfaces";
     homepage    = http://www.gtk.org/;
     license     = licenses.lgpl2Plus;
diff --git a/pkgs/development/libraries/gtk-mac-integration/default.nix b/pkgs/development/libraries/gtk-mac-integration/default.nix
new file mode 100644
index 00000000000..30ac8f2fe28
--- /dev/null
+++ b/pkgs/development/libraries/gtk-mac-integration/default.nix
@@ -0,0 +1,30 @@
+{ stdenv, lib, fetchFromGitHub, autoreconfHook, pkgconfig, glib, gtk_doc, gtk }:
+
+stdenv.mkDerivation rec {
+  name = "gtk-mac-integration-2.0.8";
+
+  src = fetchFromGitHub {
+    owner = "GNOME";
+    repo = "gtk-mac-integration";
+    rev = "79e708870cdeea24ecdb036c77b4630104ae1776";
+    sha256 = "1fbhnvj0rqc3089ypvgnpkp6ad2rr37v5qk38008dgamb9h7f3qs";
+  };
+
+  nativeBuildInputs = [ autoreconfHook pkgconfig gtk_doc ];
+  buildInputs = [ glib gtk ];
+
+  preAutoreconf = ''
+    gtkdocize
+  '';
+
+  meta = with lib; {
+    description = "Provides integration for Gtk+ applications into the Mac desktop";
+
+    license = licenses.lgpl21;
+
+    homepage = https://wiki.gnome.org/Projects/GTK+/OSX/Integration;
+
+    maintainers = [ maintainers.matthewbauer ];
+    platforms = platforms.darwin;
+  };
+}
diff --git a/pkgs/development/libraries/pango/default.nix b/pkgs/development/libraries/pango/default.nix
index f39fc2afe7d..22cf7be84d0 100644
--- a/pkgs/development/libraries/pango/default.nix
+++ b/pkgs/development/libraries/pango/default.nix
@@ -1,5 +1,5 @@
 { stdenv, fetchurl, pkgconfig, libXft, cairo, harfbuzz
-, libintlOrEmpty, gobjectIntrospection
+, libintlOrEmpty, gobjectIntrospection, darwin
 }:
 
 with stdenv.lib;
@@ -19,7 +19,12 @@ stdenv.mkDerivation rec {
   outputs = [ "bin" "dev" "out" "devdoc" ];
 
   buildInputs = [ gobjectIntrospection ];
-  nativeBuildInputs = [ pkgconfig ];
+  nativeBuildInputs = [ pkgconfig ]
+    ++ optionals stdenv.isDarwin (with darwin.apple_sdk.frameworks; [
+       Carbon
+       CoreGraphics
+       CoreText
+    ]);
   propagatedBuildInputs = [ cairo harfbuzz libXft ] ++ libintlOrEmpty;
 
   enableParallelBuilding = true;
@@ -48,6 +53,6 @@ stdenv.mkDerivation rec {
     license = licenses.lgpl2Plus;
 
     maintainers = with maintainers; [ raskin urkud ];
-    platforms = with platforms; linux ++ darwin;
+    platforms = platforms.linux ++ platforms.darwin;
   };
 }
diff --git a/pkgs/development/python-modules/pygtk/default.nix b/pkgs/development/python-modules/pygtk/default.nix
index 7d0896c1fb8..0940ef00ac9 100644
--- a/pkgs/development/python-modules/pygtk/default.nix
+++ b/pkgs/development/python-modules/pygtk/default.nix
@@ -3,7 +3,7 @@
 
 buildPythonPackage rec {
   name = "pygtk-2.24.0";
-  
+
   disabled = isPy3k;
 
   src = fetchurl {
@@ -20,6 +20,8 @@ buildPythonPackage rec {
 
   buildPhase = "buildPhase";
 
+  NIX_CFLAGS_COMPILE = stdenv.lib.optionalString stdenv.isDarwin "-ObjC";
+
   installPhase = "installPhase";
 
   checkPhase = stdenv.lib.optionalString (libglade == null)
diff --git a/pkgs/top-level/all-packages.nix b/pkgs/top-level/all-packages.nix
index e2475fdf4ef..e62fff9f127 100644
--- a/pkgs/top-level/all-packages.nix
+++ b/pkgs/top-level/all-packages.nix
@@ -7492,6 +7492,8 @@ in
 
   gtk2 = callPackage ../development/libraries/gtk+/2.x.nix {
     cupsSupport = config.gtk2.cups or stdenv.isLinux;
+    gdktarget = if stdenv.isDarwin then "quartz" else "x11";
+    inherit (darwin.apple_sdk.frameworks) AppKit Cocoa;
   };
 
   gtk3 = callPackage ../development/libraries/gtk+/3.x.nix { };
@@ -7517,6 +7519,10 @@ in
 
   gtk-sharp-beans = callPackage ../development/libraries/gtk-sharp-beans { };
 
+  gtk-mac-integration = callPackage ../development/libraries/gtk-mac-integration {
+    gtk = gtk2;
+  };
+
   gtkspell2 = callPackage ../development/libraries/gtkspell { };
 
   gtkspell3 = callPackage ../development/libraries/gtkspell/3.nix { };