diff --git a/pkgs/development/python-modules/mautrix-appservice/default.nix b/pkgs/development/python-modules/mautrix-appservice/default.nix
new file mode 100644
index 00000000000..1420f1880a3
--- /dev/null
+++ b/pkgs/development/python-modules/mautrix-appservice/default.nix
@@ -0,0 +1,28 @@
+{ lib, buildPythonPackage, fetchPypi, aiohttp, future-fstrings, pythonOlder }:
+
+buildPythonPackage rec {
+  pname = "mautrix-appservice";
+  version = "0.3.7";
+
+  src = fetchPypi {
+    inherit pname version;
+    sha256 = "1615220f5bb75e2093ad1e30f4c2e1243499b0b20caef014fd73faadd3bfea6c";
+  };
+
+  propagatedBuildInputs = [
+    aiohttp
+    future-fstrings
+  ];
+
+  # No tests available
+  doCheck = false;
+
+  disabled = pythonOlder "3.5";
+
+  meta = with lib; {
+    homepage = https://github.com/tulir/mautrix-appservice-python;
+    description = "A Python 3 asyncio-based Matrix application service framework";
+    license = licenses.mit;
+    maintainers = with maintainers; [ nyanloutre ];
+  };
+}
diff --git a/pkgs/top-level/python-packages.nix b/pkgs/top-level/python-packages.nix
index f260b6ad211..9c4b9a806a1 100644
--- a/pkgs/top-level/python-packages.nix
+++ b/pkgs/top-level/python-packages.nix
@@ -3003,6 +3003,8 @@ in {
 
   matrix-client = callPackage ../development/python-modules/matrix-client { };
 
+  mautrix-appservice = callPackage ../development/python-modules/mautrix-appservice { };
+
   maya = callPackage ../development/python-modules/maya { };
 
   mccabe = callPackage ../development/python-modules/mccabe { };