diff --git a/pkgs/development/interpreters/python/cpython/3.10/no-ldconfig.patch b/pkgs/development/interpreters/python/cpython/3.10/no-ldconfig.patch
new file mode 100644
index 00000000000..a1f9d68eb16
--- /dev/null
+++ b/pkgs/development/interpreters/python/cpython/3.10/no-ldconfig.patch
@@ -0,0 +1,100 @@
+From 597e73f2a4b2f0b508127931b36d5540d6941823 Mon Sep 17 00:00:00 2001
+From: Frederik Rietdijk <fridh@fridh.nl>
+Date: Mon, 28 Aug 2017 09:24:06 +0200
+Subject: [PATCH] Don't use ldconfig
+
+---
+ Lib/ctypes/util.py | 70 ++----------------------------------------------------
+ 1 file changed, 2 insertions(+), 68 deletions(-)
+
+diff --git a/Lib/ctypes/util.py b/Lib/ctypes/util.py
+index 5e8b31a854..7b45ce6c15 100644
+--- a/Lib/ctypes/util.py
++++ b/Lib/ctypes/util.py
+@@ -94,46 +94,7 @@ elif os.name == "posix":
+     import re, tempfile
+ 
+     def _findLib_gcc(name):
+-        # Run GCC's linker with the -t (aka --trace) option and examine the
+-        # library name it prints out. The GCC command will fail because we
+-        # haven't supplied a proper program with main(), but that does not
+-        # matter.
+-        expr = os.fsencode(r'[^\(\)\s]*lib%s\.[^\(\)\s]*' % re.escape(name))
+-
+-        c_compiler = shutil.which('gcc')
+-        if not c_compiler:
+-            c_compiler = shutil.which('cc')
+-        if not c_compiler:
+-            # No C compiler available, give up
+-            return None
+-
+-        temp = tempfile.NamedTemporaryFile()
+-        try:
+-            args = [c_compiler, '-Wl,-t', '-o', temp.name, '-l' + name]
+-
+-            env = dict(os.environ)
+-            env['LC_ALL'] = 'C'
+-            env['LANG'] = 'C'
+-            try:
+-                proc = subprocess.Popen(args,
+-                                        stdout=subprocess.PIPE,
+-                                        stderr=subprocess.STDOUT,
+-                                        env=env)
+-            except OSError:  # E.g. bad executable
+-                return None
+-            with proc:
+-                trace = proc.stdout.read()
+-        finally:
+-            try:
+-                temp.close()
+-            except FileNotFoundError:
+-                # Raised if the file was already removed, which is the normal
+-                # behaviour of GCC if linking fails
+-                pass
+-        res = re.search(expr, trace)
+-        if not res:
+-            return None
+-        return os.fsdecode(res.group(0))
++        return None
+ 
+ 
+     if sys.platform == "sunos5":
+@@ -255,34 +216,7 @@ elif os.name == "posix":
+     else:
+ 
+         def _findSoname_ldconfig(name):
+-            import struct
+-            if struct.calcsize('l') == 4:
+-                machine = os.uname().machine + '-32'
+-            else:
+-                machine = os.uname().machine + '-64'
+-            mach_map = {
+-                'x86_64-64': 'libc6,x86-64',
+-                'ppc64-64': 'libc6,64bit',
+-                'sparc64-64': 'libc6,64bit',
+-                's390x-64': 'libc6,64bit',
+-                'ia64-64': 'libc6,IA-64',
+-                }
+-            abi_type = mach_map.get(machine, 'libc6')
+-
+-            # XXX assuming GLIBC's ldconfig (with option -p)
+-            regex = r'\s+(lib%s\.[^\s]+)\s+\(%s'
+-            regex = os.fsencode(regex % (re.escape(name), abi_type))
+-            try:
+-                with subprocess.Popen(['/sbin/ldconfig', '-p'],
+-                                      stdin=subprocess.DEVNULL,
+-                                      stderr=subprocess.DEVNULL,
+-                                      stdout=subprocess.PIPE,
+-                                      env={'LC_ALL': 'C', 'LANG': 'C'}) as p:
+-                    res = re.search(regex, p.stdout.read())
+-                    if res:
+-                        return os.fsdecode(res.group(1))
+-            except OSError:
+-                pass
++            return None
+ 
+         def _findLib_ld(name):
+             # See issue #9998 for why this is needed
+-- 
+2.15.0
+
diff --git a/pkgs/development/interpreters/python/default.nix b/pkgs/development/interpreters/python/default.nix
index 90b6e8ee0cb..a8db9bc9257 100644
--- a/pkgs/development/interpreters/python/default.nix
+++ b/pkgs/development/interpreters/python/default.nix
@@ -28,6 +28,7 @@ with pkgs;
         isPy37 = pythonVersion == "3.7";
         isPy38 = pythonVersion == "3.8";
         isPy39 = pythonVersion == "3.9";
+        isPy310 = pythonVersion == "3.10";
         isPy2 = lib.strings.substring 0 1 pythonVersion == "2";
         isPy3 = lib.strings.substring 0 1 pythonVersion == "3";
         isPy3k = isPy3;
@@ -115,6 +116,19 @@ in {
     inherit passthruFun;
   };
 
+  python310 = callPackage ./cpython {
+    self = python310;
+    sourceVersion = {
+      major = "3";
+      minor = "10";
+      patch = "0";
+      suffix = "a1";
+    };
+    sha256 = "0q59a99w1yad808mx4w6l0j7bk7dbd2kakngbk0w1h9z4dhr8wyv";
+    inherit (darwin) configd;
+    inherit passthruFun;
+  };
+
   # Minimal versions of Python (built without optional dependencies)
   python3Minimal = (python38.override {
     self = python3Minimal;
diff --git a/pkgs/top-level/all-packages.nix b/pkgs/top-level/all-packages.nix
index a6f812b2252..a63bb6a9652 100644
--- a/pkgs/top-level/all-packages.nix
+++ b/pkgs/top-level/all-packages.nix
@@ -10258,7 +10258,7 @@ in
     pkgs = pkgs.extend (final: _: {
     });
   };
-  inherit (pythonInterpreters) python27 python36 python37 python38 python39 python3Minimal pypy27 pypy36;
+  inherit (pythonInterpreters) python27 python36 python37 python38 python39 python310 python3Minimal pypy27 pypy36;
 
   # Python package sets.
   python27Packages = lib.hiPrioSet (recurseIntoAttrs python27.pkgs);
@@ -10266,6 +10266,7 @@ in
   python37Packages = recurseIntoAttrs python37.pkgs;
   python38Packages = recurseIntoAttrs python38.pkgs;
   python39Packages = python39.pkgs;
+  python310Packages = python310.pkgs;
   pypyPackages = pypy.pkgs;
   pypy2Packages = pypy2.pkgs;
   pypy27Packages = pypy27.pkgs;