diff --git a/pkgs/development/libraries/libxslt/default.nix b/pkgs/development/libraries/libxslt/default.nix
index 2f913093873..62b68ff9ab8 100644
--- a/pkgs/development/libraries/libxslt/default.nix
+++ b/pkgs/development/libraries/libxslt/default.nix
@@ -41,7 +41,10 @@ stdenv.mkDerivation rec {
   propagatedBuildInputs = [ findXMLCatalogs ];
 
   # TODO move cryptoSupport as last flag, when upgrading libxslt
-  configureFlags = optional (!cryptoSupport) "--without-crypto" ++ [
+  configureFlags = []
+    ++ optional (buildPlatform != hostPlatform) "--with-libxml-prefix=${libxml2.dev}"
+    ++ optional (!cryptoSupport) "--without-crypto"
+    ++ [
     "--without-debug"
     "--without-mem-debug"
     "--without-debugger"