diff --git a/pkgs/development/python-modules/hwi/default.nix b/pkgs/development/python-modules/hwi/default.nix
new file mode 100644
index 00000000000..de9c7995bde
--- /dev/null
+++ b/pkgs/development/python-modules/hwi/default.nix
@@ -0,0 +1,51 @@
+{ lib
+, buildPythonPackage
+, fetchPypi
+, mnemonic
+, ecdsa
+, typing-extensions
+, hidapi
+, libusb1
+, pyaes
+, trezor
+, btchip
+, ckcc-protocol
+}:
+
+buildPythonPackage rec {
+  pname = "hwi";
+  version = "1.1.2";
+
+  src = fetchPypi {
+    inherit pname version;
+    sha256 = "eec460a51eb556500c1eca92015be246d5714cd53171407a76da71e4346048ae";
+  };
+
+  propagatedBuildInputs = [
+    mnemonic
+    ecdsa
+    typing-extensions
+    hidapi
+    libusb1
+    pyaes
+    trezor
+    btchip
+    ckcc-protocol
+  ];
+
+  patches = [ ./relax-deps.patch ];
+
+  # tests are not packaged in the released tarball
+  doCheck = false;
+
+  pythonImportsCheck = [
+    "hwilib"
+  ];
+
+  meta = {
+    description = "Bitcoin Hardware Wallet Interface";
+    homepage = "https://github.com/bitcoin-core/hwi";
+    license = with lib.licenses; [ mit ];
+    maintainers = with lib.maintainers; [ prusnak ];
+  };
+}
diff --git a/pkgs/development/python-modules/hwi/relax-deps.patch b/pkgs/development/python-modules/hwi/relax-deps.patch
new file mode 100644
index 00000000000..ff6c6b9768f
--- /dev/null
+++ b/pkgs/development/python-modules/hwi/relax-deps.patch
@@ -0,0 +1,16 @@
+--- a/setup.py
++++ b/setup.py
+@@ -98,10 +98,10 @@ package_data = \
+ modules = \
+ ['hwi', 'hwi-qt']
+ install_requires = \
+-['ecdsa>=0.13.0,<0.14.0',
+- 'hidapi>=0.7.99,<0.8.0',
++['ecdsa',
++ 'hidapi',
+  'libusb1>=1.7,<2.0',
++ 'mnemonic',
+- 'mnemonic>=0.18.0,<0.19.0',
+  'pyaes>=1.6,<2.0',
+  'typing-extensions>=3.7,<4.0']
+ 
diff --git a/pkgs/top-level/all-packages.nix b/pkgs/top-level/all-packages.nix
index 191b6b32ece..31d9ae88190 100644
--- a/pkgs/top-level/all-packages.nix
+++ b/pkgs/top-level/all-packages.nix
@@ -1055,6 +1055,8 @@ in
 
   httperf = callPackage ../tools/networking/httperf { };
 
+  hwi = with python3Packages; toPythonApplication hwi;
+
   ili2c = callPackage ../tools/misc/ili2c { };
 
   imageworsener = callPackage ../tools/graphics/imageworsener { };
diff --git a/pkgs/top-level/python-packages.nix b/pkgs/top-level/python-packages.nix
index b580e3f834c..acc093a3957 100644
--- a/pkgs/top-level/python-packages.nix
+++ b/pkgs/top-level/python-packages.nix
@@ -872,6 +872,8 @@ in {
 
   httptools = callPackage ../development/python-modules/httptools { };
 
+  hwi = callPackage ../development/python-modules/hwi { };
+
   i3ipc = callPackage ../development/python-modules/i3ipc { };
 
   ignite = callPackage ../development/python-modules/ignite { };