diff --git a/pkgs/applications/virtualization/qemu/default.nix b/pkgs/applications/virtualization/qemu/default.nix
index 0496adb6f40..dd68eb19380 100644
--- a/pkgs/applications/virtualization/qemu/default.nix
+++ b/pkgs/applications/virtualization/qemu/default.nix
@@ -95,6 +95,8 @@ stdenv.mkDerivation rec {
 
   preConfigure = ''
     unset CPP # intereferes with dependency calculation
+  '' + optionalString stdenv.hostPlatform.isMusl ''
+    NIX_CFLAGS_COMPILE+=" -D_LINUX_SYSINFO_H"
   '';
 
   configureFlags =