diff --git a/pkgs/development/python-modules/setuptools-rust/default.nix b/pkgs/development/python-modules/setuptools-rust/default.nix
index ee4a3b55164..cdf5e5aa27f 100644
--- a/pkgs/development/python-modules/setuptools-rust/default.nix
+++ b/pkgs/development/python-modules/setuptools-rust/default.nix
@@ -1,4 +1,5 @@
-{ lib
+{ callPackage
+, lib
 , buildPythonPackage
 , fetchPypi
 , isPy27
@@ -23,6 +24,8 @@ buildPythonPackage rec {
 
   propagatedBuildInputs = [ semantic-version setuptools toml ];
 
+  passthru.tests.pyo3 = callPackage ./pyo3-test {};
+
   meta = with lib; {
     description = "Setuptools plugin for Rust support";
     homepage = "https://github.com/PyO3/setuptools-rust";
diff --git a/pkgs/development/python-modules/setuptools-rust/pyo3-test/default.nix b/pkgs/development/python-modules/setuptools-rust/pyo3-test/default.nix
new file mode 100644
index 00000000000..9af17aa5159
--- /dev/null
+++ b/pkgs/development/python-modules/setuptools-rust/pyo3-test/default.nix
@@ -0,0 +1,21 @@
+{ callPackage
+, rustPlatform
+, setuptools-rust
+}:
+
+callPackage ../../../tools/rust/maturin/pyo3-test/generic.nix {
+  # Isolated builds break for this package, because PyO3 is not
+  # in the build root of the Python Package:
+  #
+  # https://github.com/pypa/pip/issues/6276
+  #
+  format = "setuptools";
+
+  nativeBuildInputs = [ setuptools-rust ] ++ (with rustPlatform; [
+    cargoSetupHook
+    rust.cargo
+    rust.rustc
+  ]);
+
+  sourceRoot = "source/examples/word-count";
+}