diff --git a/pkgs/development/python-modules/sphinx/default.nix b/pkgs/development/python-modules/sphinx/default.nix
index 77256ef6cff..ee3a27809af 100644
--- a/pkgs/development/python-modules/sphinx/default.nix
+++ b/pkgs/development/python-modules/sphinx/default.nix
@@ -70,12 +70,6 @@ buildPythonPackage rec {
   # Lots of tests. Needs network as well at some point.
   doCheck = false;
 
-  # https://github.com/NixOS/nixpkgs/issues/22501
-  # Do not run `python sphinx-build arguments` but `sphinx-build arguments`.
-  postPatch = ''
-    substituteInPlace sphinx/make_mode.py --replace "sys.executable, " ""
-  '';
-
   meta = {
     description = "A tool that makes it easy to create intelligent and beautiful documentation for Python projects";
     homepage = "http://sphinx.pocoo.org/";