diff --git a/pkgs/development/libraries/science/biology/htslib/default.nix b/pkgs/development/libraries/science/biology/htslib/default.nix
index a74905b5ba1..5a08e32e7e9 100644
--- a/pkgs/development/libraries/science/biology/htslib/default.nix
+++ b/pkgs/development/libraries/science/biology/htslib/default.nix
@@ -4,11 +4,11 @@ stdenv.mkDerivation rec {
   name = "${pname}-${version}";
   version = "${major}.0";
   pname = "htslib";
-  major = "1.4";
+  major = "1.5";
 
   src = fetchurl {
     url = "https://github.com/samtools/htslib/releases/download/${major}/htslib-${major}.tar.bz2";
-    sha256 = "0l1ki3sqfhawfn7fx9v7i2pm725jki4c5zij9j96xka5zwc8iz2w";
+    sha256 = "0bcjmnbwp2bib1z1bkrp95w9v2syzdwdfqww10mkb1hxlmg52ax0";
   };
 
   buildInputs = [ zlib bzip2 lzma curl ];