diff --git a/pkgs/development/compilers/ocaml/generic.nix b/pkgs/development/compilers/ocaml/generic.nix
index d4a6b6250b5..d9853dd642a 100644
--- a/pkgs/development/compilers/ocaml/generic.nix
+++ b/pkgs/development/compilers/ocaml/generic.nix
@@ -66,6 +66,10 @@ stdenv.mkDerivation (args // {
   preConfigure = optionalString (!lib.versionAtLeast version "4.04") ''
     CAT=$(type -tp cat)
     sed -e "s@/bin/cat@$CAT@" -i config/auto-aux/sharpbang
+  '' + optionalString (stdenv.isDarwin && stdenv.isAarch64) ''
+    # Do what upstream does by default now: https://github.com/ocaml/ocaml/pull/10176
+    # This is required for aarch64-darwin, everything else works as is.
+    AS="${stdenv.cc}/bin/cc -c" ASPP="${stdenv.cc}/bin/cc -c"
   '';
   postBuild = ''
     mkdir -p $out/include