diff --git a/pkgs/applications/science/biology/MACS2/default.nix b/pkgs/applications/science/biology/MACS2/default.nix
new file mode 100644
index 00000000000..cc398608ce5
--- /dev/null
+++ b/pkgs/applications/science/biology/MACS2/default.nix
@@ -0,0 +1,25 @@
+{ lib, python3, fetchurl }:
+
+python3.pkgs.buildPythonPackage rec {
+  pname = "MACS2";
+  version = "2.2.7.1";
+
+  src = python3.pkgs.fetchPypi {
+    inherit pname version;
+    sha256 = "1rcxj943kgzs746f5jrb72x1cp4v50rk3qmad0m99a02vndscb5d";
+  };
+
+  propagatedBuildInputs = with python3.pkgs; [ numpy ];
+
+  # To prevent ERROR: diffpeak_cmd (unittest.loader._FailedTest) for obsolete
+  # function (ImportError: Failed to import test module: diffpeak_cmd)
+  doCheck = false;
+  pythonImportsCheck = [ "MACS2" ];
+
+  meta = with lib; {
+    description = "Model-based Analysis for ChIP-Seq";
+    license = licenses.bsd3;
+    maintainers = with maintainers; [ gschwartz ];
+    platforms = platforms.linux;
+  };
+}
diff --git a/pkgs/top-level/all-packages.nix b/pkgs/top-level/all-packages.nix
index fef65e4d56c..f98dd0e17eb 100644
--- a/pkgs/top-level/all-packages.nix
+++ b/pkgs/top-level/all-packages.nix
@@ -28561,6 +28561,8 @@ in
 
   macse = callPackage ../applications/science/biology/macse { };
 
+  MACS2 = callPackage ../applications/science/biology/MACS2 { };
+
   migrate = callPackage ../applications/science/biology/migrate { };
 
   minia = callPackage ../applications/science/biology/minia {