diff --git a/pkgs/development/python-modules/pyvex/default.nix b/pkgs/development/python-modules/pyvex/default.nix
index 13c54f6a41e..75637acc395 100644
--- a/pkgs/development/python-modules/pyvex/default.nix
+++ b/pkgs/development/python-modules/pyvex/default.nix
@@ -2,20 +2,20 @@
 , stdenv
 , archinfo
 , bitstring
-, fetchPypi
-, cffi
 , buildPythonPackage
+, cffi
+, fetchPypi
 , future
 , pycparser
 }:
 
 buildPythonPackage rec {
   pname = "pyvex";
-  version = "9.0.5903";
+  version = "9.0.6281";
 
   src = fetchPypi {
     inherit pname version;
-    sha256 = "sha256-qhLlRlmb48zhjX2u9w6TVVv2gb0E9kSapabiv+u4J2s=";
+    sha256 = "sha256-E8BYCzV71qVNRzWCCI2yTVU88JVMA08eqnIO8OtbNlM=";
   };
 
   propagatedBuildInputs = [
@@ -26,6 +26,11 @@ buildPythonPackage rec {
     pycparser
   ];
 
+  postPatch = ''
+    substituteInPlace pyvex_c/Makefile \
+      --replace "CC=gcc" "CC=${stdenv.cc.targetPrefix}cc"
+  '';
+
   # No tests are available on PyPI, GitHub release has tests
   # Switch to GitHub release after all angr parts are present
   doCheck = false;