diff --git a/pkgs/development/python-modules/pybigwig/default.nix b/pkgs/development/python-modules/pybigwig/default.nix
new file mode 100644
index 00000000000..be54a38cd99
--- /dev/null
+++ b/pkgs/development/python-modules/pybigwig/default.nix
@@ -0,0 +1,33 @@
+{ lib
+, buildPythonPackage
+, fetchPypi
+, pytest
+, numpy
+, zlib
+}:
+
+buildPythonPackage rec {
+  pname = "pyBigWig";
+  version = "0.3.17";
+
+  src = fetchPypi {
+    inherit pname version;
+    sha256 = "157x6v48y299zm382krf1dw08fdxg95im8lnabhp5vc94s04zxj1";
+  };
+
+  buildInputs = [ zlib ];
+
+  checkInputs = [ numpy pytest ];
+
+  meta = with lib; {
+    homepage = "https://github.com/deeptools/pyBigWig";
+    description = "File access to bigBed files, and read and write access to bigWig files";
+    longDescription = ''
+      A python extension, written in C, for quick access to bigBed files
+      and access to and creation of bigWig files. This extension uses
+      libBigWig for local and remote file access.
+    '';
+    license = licenses.mit;
+    maintainers = with maintainers; [ scalavision ];
+  };
+}
diff --git a/pkgs/top-level/python-packages.nix b/pkgs/top-level/python-packages.nix
index 3876b7b48c9..ea114f2dd65 100644
--- a/pkgs/top-level/python-packages.nix
+++ b/pkgs/top-level/python-packages.nix
@@ -4447,6 +4447,8 @@ in {
 
   pybfd = callPackage ../development/python-modules/pybfd { };
 
+  pybigwig = callPackage ../development/python-modules/pybigwig { };
+
   py2bit = callPackage ../development/python-modules/py2bit { };
 
   pyblock = callPackage ../development/python-modules/pyblock { };