diff --git a/pkgs/development/libraries/libusb1/default.nix b/pkgs/development/libraries/libusb1/default.nix
index 65023814171..5d6a20b13a4 100644
--- a/pkgs/development/libraries/libusb1/default.nix
+++ b/pkgs/development/libraries/libusb1/default.nix
@@ -33,7 +33,9 @@ stdenv.mkDerivation rec {
 
   NIX_LDFLAGS = stdenv.lib.optionalString stdenv.isLinux "-lgcc_s";
 
-  preFixup = stdenv.lib.optionalString stdenv.isLinux ''
+  configureFlags = stdenv.lib.optional (!enableSystemd) "--disable-udev";
+
+  preFixup = stdenv.lib.optionalString enableSystemd ''
     sed 's,-ludev,-L${stdenv.lib.getLib systemd}/lib -ludev,' -i $out/lib/libusb-1.0.la
   '';