diff --git a/pkgs/applications/science/physics/sacrifice/default.nix b/pkgs/applications/science/physics/sacrifice/default.nix
index d6aeeedc086..99d6df77f85 100644
--- a/pkgs/applications/science/physics/sacrifice/default.nix
+++ b/pkgs/applications/science/physics/sacrifice/default.nix
@@ -27,6 +27,10 @@ stdenv.mkDerivation rec {
     "--with-pythia=${pythia}"
   ];
 
+  postInstall = stdenv.lib.optionalString stdenv.isDarwin ''
+    install_name_tool -add_rpath ${pythia}/lib "$out"/bin/run-pythia
+  '';
+
   enableParallelBuilding = true;
 
   meta = {