270 lines
12 KiB
Plaintext
270 lines
12 KiB
Plaintext
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Common Name: Diazomethane
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CAS Number: 334-88-3
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DOT Number: None
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Date: March, 1986
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HAZARD SUMMARY
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* Diazomethane can affect you when breathed in.
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* It is extremely toxic. Exposure can cause severe lung damage
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with symptoms of coughing, chest pain, shortness of breath,
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fever and fatigue. These may not be felt until hours or days
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after exposure and this can cause death.
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* Exposure to the gas or liquid can cause severe skin burns and
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eye damage.
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* Repeated exposures, even at low levels, may cause an asthma-
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like lung allergy.
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* Heat, sunlight, or other bright lights can cause it to
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explode. Contact with alkali metals, drying agents and rough
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edges can also cause explosions.
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IDENTIFICATION
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Diazomethane is a yellow gas at room temperature. It can also
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exist as a liquid under pressure. It is used in making other
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chemicals.
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REASON FOR CITATION
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* Diazomethane is on the Hazardous Substance List because it is
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regulated by OSHA and cited by ACGIH.
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HOW TO DETERMINE IF YOU ARE BEING EXPOSED
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* Exposure to hazardous substances should be routinely
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evaluated. This may include collecting personal and area air
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samples. You can obtain copies of sampling results from your
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employer. You have a legal right to this information under
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OSHA 1910.20.
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* If you think you are experiencing any work-related health
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problems, see a doctor trained to recognize occupational
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diseases. Take this Fact Sheet with you.
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WORKPLACE EXPOSURE LIMITS
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OSHA: The legal airborne permissible exposure limit (PEL) is
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0.2 ppm averaged over an 8-hour work-shift.
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ACGIH: The recommended airborne exposure limit is 0.2 ppm
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averaged over an 8-hour workshift.
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WAYS OF REDUCING EXPOSURE
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* Where possible, enclose operations and use local exhaust
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ventilation at the site of chemical release. If local exhaust
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ventilation or enclosure is not used, respirators should be
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worn.
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* Wear protective work clothing.
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* Wash thoroughly immediately after exposure to Diazomethane.
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* Post hazard and warning information in the work area. In
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addition, as part of an ongoing education and training effort,
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communicate all information on the health and safety hazards
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of Diazomethane to potentially exposed workers.
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This Fact Sheet is a summary source of information of all potential
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and most severe health hazards that may result from exposure.
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Duration of exposure, concentration of the substance and other
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factors will affect your susceptibility to any of the potential
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effects described below.
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HEALTH HAZARD INFORMATION
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Acute Health Effects
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The following acute (short-term) health effects may occur
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immediately or shortly after exposure to Diazomethane:
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* Breathing Diazomethane gas or vapors can cause severe lung
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damage. Immediate symptoms may include coughing, wheezing,
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shortness of breath, chest pain, dizziness, fatigue, headache,
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and irritation of the mouth, nose and throat. Nausea,
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vomiting, and fever may also occur. This can progress to a
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build-up of fluid in the lungs (pulmonary edema) and death.
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The effects may not be felt for hours or days after exposure.
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* Contact with Diazomethane gas, liquefied gas, or solutions can
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cause severe eye burns and permanent damage.
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* Skin contact can cause severe irritation, burns and scaling of
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the affected body area. Similar symptoms may occur on the
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skin inside the mouth, nose and throat following inhalation.
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Chronic Health Effects
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The following chronic (long-term) health effects can occur at some
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time after exposure to Diazomethane and can last for months or
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years:
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Cancer Hazard
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* According to the information presently available to the New
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Jersey Department of Health, Diazomethane has not been tested
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for its ability to cause cancer in animals.
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Reproductive Hazard
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* According to the information presently available to the New
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Jersey Department of Health, Diazomethane has not been tested
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for its ability to affect reproduction.
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Other Long-Term Effects
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* Repeated exposure to Diazomethane can cause an asthma-like
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lung allergy. Symptoms may include coughing, wheezing, and
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fatigue. The symptoms may become progressively worse with
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repeated attacks, and permanent lung damage (emphysema) may
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result.
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MEDICAL
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Medical Testing
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Before beginning employment and at regular times after that, the
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following are recommended:
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* Lung function tests. These may be normal at first if the
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person is not having an attack at the time.
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If symptoms develop or overexposure is suspected, the following may
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be useful:
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* Evaluation by a qualified allergist, including careful
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exposure history and special testing, may help diagnose
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allergy.
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* Consider chest x-ray after acute over-exposure.
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Any evaluation should include a careful history of past and present
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symptoms with an exam. Medical tests that look for damage already
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done are not a substitute for controlling exposure.
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Request copies of your medical testing. You have a legal right to
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this information under OSHA 1910.20.
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Mixed Exposures
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Because smoking can cause heart disease, as well as lung cancer,
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emphysema, and other respiratory problems, it may worsen
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respiratory conditions caused by chemical exposure. Even if you
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have smoked for a long time, stopping now will reduce your risk of
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developing health problems.
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WORKPLACE CONTROLS AND PRACTICES
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Unless a less toxic chemical can be substituted for a hazardous
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substance, ENGINEERING CONTROLS are the most effective way of
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reducing exposure. The best protection is to enclose operations
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and/or provide local exhaust ventilation at the site of chemical
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release. Isolating operations can also reduce exposure. Using
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respirators or protective equipment is less effective than the
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controls mentioned above, but is sometimes necessary.
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In evaluating the controls present in your workplace, consider: (1)
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how hazardous the substance is, (2) how much of the substance is
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released into the workplace and (3) whether harmful skin or eye
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contact could occur. Special controls should be in place for
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highly toxic chemicals or when significant skin, eye, or breathing
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exposures are possible. In addition, the following control is
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recommended:
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* Where possible, automatically transfer Diazomethane from
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cylinders or other storage containers to process containers.
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Good WORK PRACTICES can help to reduce hazardous exposures. The
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following work practices are recommended:
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* Workers whose clothing has been contaminated by liquid
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Diazomethane should change into clean clothing promptly.
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* Do not take contaminated work clothes home. Family members
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could be exposed.
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* Contaminated work clothes should be laundered by individuals
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who have been informed of the hazards of exposure to
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Diazomethane.
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* Eye wash fountains should be provided in the immediate work
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area for emergency use.
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* If there is the possibility of skin exposure, emergency shower
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facilities should be provided.
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* On skin contact with Diazomethane, immediately wash or shower
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to remove the chemical.
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* Do not eat, smoke, or drink where Diazomethane is handled,
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processed, or stored, since the chemical can be swallowed.
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Wash hands carefully before eating or smoking.
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PERSONAL PROTECTIVE EQUIPMENT
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WORKPLACE CONTROLS ARE BETTER THAN PERSONAL PROTECTIVE EQUIPMENT.
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However, for some jobs (such as outside work, confined space entry,
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jobs done only once in a while, or jobs done while workplace
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controls are being installed), personal protective equipment may be
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appropriate.
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The following recommendations are only guidelines and may not apply
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to every situation.
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Clothing
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* Avoid skin contact with Diazomethane. Wear protective gloves
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and clothing. Safety equipment suppliers/manufacturers can
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provide recommendations on the most protective glove/clothing
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material for your operation.
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* All protective clothing (suits, gloves, footwear, headgear)
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should be clean, available each day, and put on before work.
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Eye Protection
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* Wear splash-proof chemical goggles and face shield when
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working with liquid Diazomethane, or gas-proof goggles when
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working with the gas, unless full facepiece respiratory
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protection is worn.
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Respiratory Protection
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IMPROPER USE OF RESPIRATORS IS DANGEROUS. Such equipment should
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only be used if the employer has a written program that takes into
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account workplace conditions, requirements for worker training,
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respirator fit testing and medical exams, as described in OSHA
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1910.134.
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* Where the potential exists for exposures over 0.2 ppm, use a
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MSHA/NIOSH approved supplied-air respirator with a full
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facepiece operated in the positive pressure mode or with a
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full facepiece, hood, or helmet in the continuous flow mode,
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or use a MSHA/NIOSH approved self-contained breathing
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apparatus with a full facepiece operated in pressure-demand or
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other positive pressure mode.
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* Exposure to 10 ppm is immediately dangerous to life and
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health. If the possibility of exposures above 10 ppm exists,
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use a MSHA/NIOSH approved self-contained breathing apparatus
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with a full facepiece operated in continuous flow or other
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positive pressure mode.
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HANDLING AND STORAGE
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* Prior to working with Diazomethane you should be trained on
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its proper handling and storage.
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* Diazomethane must be stored to avoid contact with ALKALI
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METALS, such as LITHIUM, SODIUM, or POTASSIUM; or DRYING
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AGENTS, such as CALCIUM SULFATE, since violent reactions
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occur.
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* Store in tightly closed containers in a cool well-ventilated
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area away from HEAT and LIGHT. The pure liquid material
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explodes above 302oF, whereas impure material explodes at
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lower temperatures. Exposure of the gas or solutions to
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SUNLIGHT or other BRIGHT LIGHTING may cause an explosion.
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Contact with ROUGH EDGES, such as found on ground glass, may
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cause an explosion. Safety barriers or shields should be used
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to protect workers from accidental explosions.
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* Sources of ignition such as smoking and open flames are
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prohibited where Diazomethane is handled, used, or stored.
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* Metal containers used in the transfer of 5 gallons or more of
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Diazomethane should be grounded and bonded. Drums must be
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equipped with self-closing valves, pressure vacuum bungs, and
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flame arresters.
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* Use only non-sparking tools and equipment, especially when
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opening and closing containers of Diazomethane.
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* Wherever Diazomethane is used, handled, manufactured, or
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stored, use explosion-proof electrical equipment and fittings.
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Common Name: Diazomethane
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DOT Number: None
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DOT Emergency Guide code: No Citation
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CAS Number: 334-88-3
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-----------------------------------------
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Hazard rating NJ DOH NFPA
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FLAMMABILITY Not Found
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REACTIVITY Not Found
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EXPLOSIVE LIQUID
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----------------------------------------
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Hazard Rating Key: 0=minimal; 1=slight; 2=moderate; 3=serious;
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4=severe
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FIRE HAZARDS
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* Diazomethane will explode in a fire. In the event of a fire,
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immediately evacuate the area.
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