246 lines
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246 lines
10 KiB
Plaintext
Newsgroups: alt.psychoactives
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Subject: Re: LSD dosages
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Message-ID: <2N557B1w165w@qedbbs.com>
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From: marsthom@qedbbs.com (Mark Thompson)
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Date: 23 Jul 93 12:32:00 GMT
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[some stuff deleted -cak]
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Abstracts regarding low doses of LSD (Less than 50 mcg)
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Bibliography on Psychotomimetics 1943-1966
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Reprinted with permission of Sandoz Pharmaceuticals by
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US Department of Health, Education & Welfare, Public Health Service
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National Institute of Mental Health
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RM315.Z9 S23
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GREINER T, BURCH N R, EDELBERT R
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Psychopatholgy and psychophysiology of minimal LSD-25 dosage.
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A prelimiary dosage-response spectrum.
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Arch.Neurol.& Psychiat. 79:208 (1958)
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Double-blind studies on 14 healthy subjects confirmed that LSD fails
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to elicit a physiological response in doses less than 20 mcg.
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Dramatic psychic symptoms, e.g. deviations from normal in body image,
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thought, and emotion, occurred only with dosages in excess of 20 mcg.
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However, careful observation and questioning revealed certain changes
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in affect and psychomotor activity with doses as low as 7 mcg.
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Classical schizophrenia-like symptoms first begin to appear when the
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dose exceeded 30 mcg.
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STOLL W A
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Lysergsaure-diathyl-amid, ein Phantastikum aus der Mutterkorngruppe.
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(LSD, a hallucinatory aggent from the ergot group)
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Schweiz.Arch.Neur. 60 (1947).
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A report is made of the mental effects of LSD. LSD was administered
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on 29 occasions to 16 normal subjects and on 20 occasions to 6
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schizophrenics. LSD produced a state of intoxication of the acute
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exogenic reaction type. Stress is laid on the fact that LSD is active
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in very small amounts (20-30 mcg. orally).
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STOLL W A
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Ein neues, in sehr kleinen Mengen wirsames Phantastikum.
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(An new hallucinatory agent, active in very small amounts)
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Schweiz, Arch, Neur. 60,483 (1947).
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20-30 mcg. LSD given orally to mentally normal subjects produced an
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intoxication of the acute exogenic reaction type lasting several
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hours. LSD produced autonomic and motor symptoms, disturbances of
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optical perception, clouding of consciousness, a tendency to
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euphoria, etc.
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DELAY J, PICHOT P
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Diethylamide de l'acide d-lysergique et troubles psychiques de
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l'ergotisme.
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(LSD and psychic disorders in ergotism)
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C.r. Soc. Biol. 145,1609 (1951)
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The authors observed after 20-50 mcg. LSD euphoria with compulsive
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laughter, depression, mental disorders and even slight states of
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confusion. In some cases, there were visual illusions, hallucinations
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resembling those caused by mescaline, disorders of synaesthesia and
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posture sense. The authors find a [superficial] similarity between
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the effects of LSD and the psychic symptoms observed in epidemics of
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ergotism.
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GAUSTAT H, FERRER S, CASTELIS C, LESERVE N, LUSHNAT K
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Action de las diethylamid de l'acide d-lysergique (LSD-25) sur les
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fonctions
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psychiques et l'electroencephalogramme.
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(Effect of LSD on mental functions and the EEG)
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In 7 of 12 normal subjects 40-60 mcg. LSD orally produced autonomic,
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psychic and EEG responses. In 4 subjects only 1 or 2 of these
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responses were observed. In 1 case LSD had no effect. The effects are
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considered to be an expression of neurotic hyperexcitability
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(shortening of refractory period) and a reduction in the "filtering"
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of impulses through nervous centers.
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ARNOLD O H, HOFF H
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Untersuchungen uber die Wirkingsweise von Lysergsaurediathylamid. (1.
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Mittelung.)
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(Investigations on teh mode of action of LSD (1st communication))
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Wein. Ztschr.Nerenh. 6,129 (1953)
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Normal subjects exhibit "specific" reactions to 25-100 mcg. LSD:
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disturbances of self-awareness, ideation and perception. Chronic
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alcoholics do not exhibit these reactions, especially after delirium
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tremens. In Korsakow's syndrome the specific reactions are absent
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only when lower portions of the brain (medulla, midbrain) are
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affected. Delirium tremens produces symptoms which are similar to
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those produced by LSD but of greater intensity.
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FREDERKING W
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Ueber die Verwendung von Raushdrogen (mesklan und
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Lysergsaurediaethylamid) in
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der Psychotherapie.
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(The use of LSD and mescaline in psychotherapy)
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Psyche 7,342 (1953/54)
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LSD (40-60 mcg. orally) and mescaline (0.3-0.5 Gm i.m.) were used in
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neurotic patients refreactory to psychoanalysis. Over 100
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"intoxication" studies (including author's personal investigations).
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LSD employed in 60 instances. The "intoxication", as does a dream,
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exerted a therapeutic effect aiding psychoanalysis (24 cases
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described). The therapeutic effect of LSD was better than that of
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mescaline. Caution is required in cases of anxiety states and
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suspected schizophrenia. The author strongly recommends that each
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physician using LSD should, under supervision, study the effect of a
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high dose of LSD himself in order to facilitate interpretation of a
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patient's experiences under LSD.
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GAMNA G, BOFANTE B, VILLATA E
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Autoesperienze con LSD
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(Personal studies with LSD)
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Four studies were made of 10 and 50 mcg. LSD orally (by two
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psychiatrists and one chaplain). The mental symptoms were relatively
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few and were accompanied by sympaticotonia, neutrophilia and an
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increase in gamma globulin.
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ROUBICEK J
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Toxicke a experimentali dusveni porouchy
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(Toxic and experimental psychoses)
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Csl.Psychiat. 56,8 (1960)
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Based on previous studies, the author emphasizes the importance of
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the experimental psychoses, which are provoked by LSD or Psilocybin,
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for research and psychicatric therapy.
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Especially emphasized is that small doses of LSD(30-40mcg.) or
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Psilocybin can be used with good results in ambulant treatment of
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psychoneurotic and psychosomatic disorders. 200 patients received
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LSD, some on several occasions. Only 2 unpleasant situations occurred
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(sexual aggression towards the therapist). The influence of LSD and
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mescaline on the artistic ability of professional and amateur
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painters is also reported.
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SAVAGE C
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Variations in ego feeling induced by d-lysergic acid diethylamide
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(LSD-25)
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Psychoanalyt.Rev. 42:1 (1955)
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Report on 300 observations of LSD in 32 hospitalized mental patients
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and 6 normal controls. The dosage employed was 10-100 mcg. orally or
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parenterally. In normal subjects an effect was produced by 10 mcg.
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but in acute schizophrenics 100 mcg. was required to produce a much
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slighter effect. In acute schizophrenics the symptoms caused by LSD
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appeared to be an exaggferation of symptoms that already existed.
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Chronic schisophrenicsa exhibited behavior similar to that observed
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in acute episodes. Schizoid patients with depression and involutional
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depressives (most subjects developed tolerance to LSD after repeated
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doses.) It is concluededt hat LSD makes it impossible for the ego to
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integrate the evidence of its senses and to coordinate its
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activities.
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ABRAMSON H A
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Lysergic Acid Diethylamide(LSD-25): XIX. As an adjunct to brief
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psychotherapy,
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with special reference to ego enhancement.
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J.Psychol. 41:199 (1956)
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1. Previous data on the nature of the ego enhancement occuring during
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the LSD-25 reaction is amplified by making a direct comaprison with
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the ego depression simultaneously occuring. During the LSD-25
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reaction advantage may be taken of the integrative function of the
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ego if the therapist recognizes the presence of the processes of ego
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reinforcement.
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2. Although ego depression may occur during the LSD-25 reaction to
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produce a psychotic state, this state is associated primarily with
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doses greater than 50 micrograms by mouth. The nature of the ego
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depression is shown by a verbatim recording. The subject was
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essentially incapable of communicating effectively with the
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interviewer during the height of the LSD-25 response.
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3. The nature of the integrative processes during ego enhancement
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with small doses of LSD-25 (20 to 50 micrograms) is illustrated by
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verbatim recordings. It is emphasized that during the LSD-25
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reaction, the integrative functions of the ego often operate
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effectively to utilize preconscious and unconscious material during
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therapeutic interviews lasting as long as four hours and covering
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periods of observation lasting six hours. Whether or not the LSD-25
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reaction develops into one where ego reinforcement or one where ego
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depression is emphasized depends to a great extent upon the
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relationship of the therapist to the patient. During the same
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therapeutic interview the therapist can manipulate the nature of the
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response.
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4. It is beleived that LSD-25 may be utilized to more effectively
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mobilize psychodynamic vectors during the analysis of the
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transference.
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5. In non-psychotic groups studied, important relationships developed
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amongst groups consisting of two to five members. These always led to
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some insight and better adaptive techniques both at work and in
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community activities on the part of the subjects who met repeatedly.
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This suggests the possible use of LSD-25 as an adjuvant to group
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therapy.
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6. Preliminary data are reported on the effect of LSD-25 on the
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reassociation of dreams. It is stressed that verbatim recordings are
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a necessary condidton for the successful utilizatio of dream
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reassociation.
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BERLIN L, GUTHRIE T, WIEDER A, GOODELL H, WOLFF H G
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Studies in human cerebral function: the effects of mescaline and lysergic
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acid on cerebral processes pertinent to creative activity.
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J.Nerv & Ment.Dis. 122:487 (1955)
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LSD (50 mcg.) or mescaline (400-700 mg) orally impaired the highest
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integrative functions of 4 graphic artists. Drawings revealed an
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unusual expansiveness and relaxation of control, both colour and line
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being free and bold. (black and white illustrations). No major
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difference in effect between LSD and mescaline. Similar impairment of
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functions was noted in a playwright given 50 mcg LSD orally.
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ABRAMSON H A, JARVIK M E, LEVINE A, KAUFMAN M R, HIRSH M W
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"Lysergic acid diethylamide (LSD-25): XV. The effects produced by
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substitution of a tap water placebo."
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J.Psychol. 40:367 (1955)
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Studies in 33 normal subjects revealed that tap water is capable of
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eliciting certain responses from certain subjects who believe they
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have received LSD.
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