108 lines
4.0 KiB
Plaintext
108 lines
4.0 KiB
Plaintext
Newsgroups: alt.drugs
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From: andersom@spot.Colorado.EDU (Marc Anderson)
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Subject: Re: Info on methcathinone
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Message-ID: <1993Jul1.222440.8062@ucsu.Colorado.EDU>
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Date: Thu, 1 Jul 1993 22:24:40 GMT
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-----BEGIN PGP SIGNED MESSAGE-----
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[some text deleted -cak]
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medline only has two entries for 'methcathinone', both of which follow:
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- -marc
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andersom@spot.colorado.edu
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- ---------- cut here ---------
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AU - Glennon RA
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AU - Yousif M
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AU - Naiman N
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AU - Kalix P
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TI - Methcathinone: a new and potent amphetamine-like agent.
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AB - The purpose of the present investigation was to examine the effect of
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N-monomethylation of phenylisopropylamine derivatives on amphetamine-
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like activity. In tests of stimulus generalization using rats trained
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to discriminate 1.0 mg/kg of (+)-amphetamine from saline, the N-
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monomethyl derivatives of 1-(X-phenyl)-2-aminopropane, where X = 2,4-
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dimethoxy (2,4-DMA), 3,4-dimethoxy (3,4-DMA), 2,4,5-trimethoxy
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(2,4,5,-TMA), and 2-methoxy-4,5-methylenedioxy (MMDA-2), did not
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produce amphetamine-appropriate responding at the doses evaluated.
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However, the N-monomethyl derivative of cathinone (i.e.,
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methcathinone), like cathinone, resulted in stimulus generalization.
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Further studies with this agent revealed that (a) in the amphetamine-
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trained animals, methcathinone (ED50 = 0.37 mg/kg) is more potent
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than racemic cathinone or racemic amphetamine (ED50 = 0.71 mg/kg in
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both cases), (b) methcathinone is capable of inducing release of
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radioactivity from [3H]dopamine-prelabeled tissue of rat caudate
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nucleus in a manner similar to that observed with cathinone,
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amphetamine, and methamphetamine, and (c) methcathinone is more
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potent than cathinone as a locomotor stimulant in mice as determined
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by their effect on spontaneous activity. The results of the present
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study provide evidence for a structural analogy between the
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prototypic psychostimulants amphetamine/methamphetamine and
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cathinone/methcathinone, and lend further support to the concept that
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amphetamine and cathinone correspond in their pharmacological
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effects.
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SO - Pharmacol Biochem Behav 1987 Mar;26(3):547-51
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DP - 1987 Mar
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TA - Pharmacol Biochem Behav
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PG - 547-51
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IP - 3
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VI - 26
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IS - 0091-3057
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UI - 87204443
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AU - Goldstone MS
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TI - 'Cat': methcathinone--a new drug of abuse [letter]
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AB - [No Abstract Available]
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SO - JAMA 1993 May 19;269(19):2508
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DP - 1993 May 19
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TA - JAMA
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PG - 2508
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IP - 19
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VI - 269
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IS - 0098-7484
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UI - 93253905
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-----BEGIN PGP SIGNATURE-----
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Version: 2.2
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iQBVAgUBLDNkHMUtKvnPICaNAQFfUgH/WRrFv/IMAFRBJTYH93igJSqY+SxTFXxw
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YpU005KcJ8DRDEU7Tbmx99rUkvLppDGseLP2Ac8JH8aW9N11L8jVSQ==
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=yz0/
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-----END PGP SIGNATURE-----
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=============================================================================
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From: ebrandt@jarthur.cs.hmc.edu (Eli Brandt)
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Newsgroups: alt.drugs
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Subject: Re: Homemade cat
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Date: 10 Jun 1994 03:51:55 GMT
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Message-ID: <2t8o0r$kjb@jaws.cs.hmc.edu>
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In article <135322Z09061994@anon.penet.fi>, Mud Phud <an97259@anon.penet.fi> wrote:
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>I found it to be much, much weaker than meth. The onset is slightly
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>slower (nasal route), there is no euphoria/rush, the high is like a
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>buzz with some of the heightened concentration and detail perception
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>ability, and the effects don't last as long as meth. I had no trouble
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>sleeping at night, unlike with a meth high.
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>
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>My question to the expert chemists in the group is why this might
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>be so. The cat refs on hmc seem to indicate that methcathinone and
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>methamphetamine should have equivalent or nearly equivalent effects.
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Maybe not. I have some notes comparing cathinone (the active principle
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of qat) with amphetamine. Rosecran et al. found that cathinone lacked
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DA agonist activity, and showed less disruption of behavior in animal
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studies. This is in Harris (ed.), _Problems of drug dependence_, NIDA,
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Monograph #27. I don't know whether this generalizes to methcathinone.
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Eli ebrandt@hmc.edu
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finger for PGP key.
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The above text is worth
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precisely its weight in gold.
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