530 lines
21 KiB
Plaintext
530 lines
21 KiB
Plaintext
*************************** Article Separation ********************************
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Hi folks,
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for all those interested in addresses for nootropics, here they are:
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InHome Health Services
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box 3112
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CH-2800 Delemont
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Switzerland
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INTERLAB
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PO Box 587
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Newprt Pagnell
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Bucks
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MK168AA England
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and.....
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WRN Research
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POB 839 Station A
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Montreal, Canada H3C 2V5
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This companies may supply one or more of the following:
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Piracetam
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pyrogluamate
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Vinpocetine
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Acetyl-L-carnitine
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Centrophenoxine (lucidril)
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Choline
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AL721 (egg lecithin)
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DHEA (alliance 7 San diego 619-291-5360, HAF San fran 415-626-2316 &
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PDA New York 212-532-0363 )
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Deaner (DMAE)
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GEROVITAL (GH-3)
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Hydergine
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Phenytoin (Dilantin)
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Propranolol Hydrochloride (Inderal)
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Vasopressin (Diapid) nasal spray only
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Vincamine
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Xanthinol Nicotinate
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L-tryptophan
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L-Phenylalanine
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And a host of Aminos, Vitamins and assorted goodies. GOOD LUCK!!
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PS - new book, "Smart drugs & nutrients" Ward Dean, M.D. & john Morgenthaler
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Addr - B&J Publication, P.O. Box 483, Santa Cruz, CA 95061-0483
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IF YOU SEND A SASE, THEY WILL SEND YOU A LIST OF PHYSICIANS KNOWLEDGEABLE
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ABOUT SMART DRUGS & NUTRIENTS !! PLUS THEY HAVE A NEWLETTER FOR FREE!!!
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***************************** Article Separation ******************************
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Earlier, there were some questions about amino acids on alt.drugs.
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I posted a scanty summary of some of aminos I was interested in.
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More questions appeared after that, posted and in my mail box.
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This file is quite a bit more complete but still doesn't list
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many of the 22 or so AAs. (eg. alanine, histidine, idoleucine,
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proline, serine, threonine, valine... these are all common, but
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i haven't found much info on them).
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Documentation and sources are missing, so please don't take this
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file too seriously. I probably won't create another version of
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this for a while.
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(Note that this is a Folded file, for those with MSDOS machines and
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the shareware editor.)
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=============================
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AMINO ACIDS AND THEIR EFFECTS
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=============================
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Version 1.1
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Compiled by: Bj Krawchuk (krawchuk@cpsc.ucalgary.ca)
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Several sources have been used and may be requested from above.
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(*@/// Phenylalanine *)
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(*@/// L-phenylalanine *)
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L-phenylalanine
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- converted into tyrosine which is
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precursor to noradrenaline (NE) and dopamine
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- like all amino acids best taken on empty stomach since it competes
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with proteins to cross the blood brain barrier.
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- requires vitamins C and B-6 for the conversion to NE.
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- Dosage: 500 - 1000mg along with 1g C, 30-50mg B-6
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- phenylalanine also stimulates the release of
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cholecystokinin, which is the body's own appetite-suppressant,
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- can increase sexual interest
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- improves memory and mental alertness
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- antidepressant
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- do not use L-phenylalanine or L-tyrosine if you are
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using MAO inhibitors for depression (it can cause a
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major elevation in blood pressure).
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(*@\\\*)
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(*@/// DL-phenylalanine *)
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DL-phenylalanine
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- combination of synthetic (D) and natural (L) phenylalanine
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- produces endorphins and stimulates their use
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- thus, effective painkiller, often better than the
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opiate derivatives such as morphine.
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- nonaddictive, nontoxic
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- reverse-tolerance effect (pain relief gets better)
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- strong anti-depressant effect
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- can be combined with other pain-killers
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with few bad interactions
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(*@\\\*)
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(*@\\\*)
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(*@/// Tyrosine *)
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L-tyrosine
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- precursor to norepinephrine and dopamine
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- non-essential amino acid (since PA is converted into it first)
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- has been studied as an effective aid to cocaine withdrawal
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- (see L-phenylalanine)
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(*@\\\*)
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(*@/// Tryptophan *)
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L-tryptophan
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- precursor to the neurotransmitter serotonin along with
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B6, niacin, and magnesium.
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- (actually immediate precursor to 5-hydroxytryptophan (5HTP)
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which is the precursor to serotonin (5HT))
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- prolongs slow-wave sleep
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- reduces pain sensitivity
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- no effect or increases REMS
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- has some hypnotic effects
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- useful for some types of endogenous depression
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(has been found as useful as imipramine and amitriptyline)
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- aids in reducing anxiety and tension
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- an appetite supressant
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- dosages have been studied up to 15g
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- Major Food Sources:
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Cottage cheese, milk, meat, fish, turkey, bananas,
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dried dates, peanuts, all protein-rich foods.
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(*@\\\*)
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(*@/// Lysine *)
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L-lysine
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- needed for growth and enzyme, hormone, antibody production
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- aids concentration
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- treatment for some sterility problems
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- treatment and prevention for herpes infections
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- aids fatty acid -> energy conversion
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(*@\\\*)
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(*@/// Arginine *)
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L-arginine
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- used to increase sperm counts
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(semen contains up to 80% of arginine)
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- aids immune response and healing of wounds
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- helps stored fat metabolism
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- helps to tone muscle tissue
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- used for weight-loss in combination with L-ornithine
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- one amino acid required for production of growth hormone
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(*@\\\*)
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(*@/// Ornithine *)
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L-ornithine
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- similar to arginine
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- growth hormone (which acts as a fat metabolizer) is
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stimulated to be released by ornithine and arginine.
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- can be used as a slimming technique (while you sleep -
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GH is released by the pituitary gland then)
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(*@\\\*)
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(*@/// Glutamine *)
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L-glutamine
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- converted to glutamic acid, the brain's emergency source of
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energy when glucose is in short supply.
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- precursor to the neurotransmitter GABA
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- neutralizes excess ammonia (which can inhibit proper
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brain function)
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- improves intelligence
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- helps to control alcoholism
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- helps to speed ulcer healing
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- alleviates fatigue, depression, impotence,
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schizophrenia, senility
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(*@\\\*)
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(*@/// Aspartic Acid *)
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L-aspartic acid
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- ammonia neutralizer
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- a study showed improved stamina and endurance in atheletes
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(*@\\\*)
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(*@/// Cysteine *)
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L-cysteine
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- cystine is its stable form
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- antioxidant
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- contains sulfur
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- protects cellular membranes from "free radical damage"
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- prevents alcohol and cigarette smoke damage to the brain
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- stimulant to immune system
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- believed to be good for antiaging
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- effective against copper toxicity (eg. Wilson's disease)
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- protects against X-ray and nuclear radiation
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- warning: may affect insulin effectiveness
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(*@\\\*)
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(*@/// Methionine *)
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L-methionine
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- antioxidant
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- contains sulfur
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- prevents damage of brain cells from toxic heavy metals
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- important in producing neurotransmitters and energy
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- lowers blood level of histamine
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(this may help some types of schizophrenia)
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- combined with choline and folic acid, can prevent some
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types of tumors
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- deficiencies: hair loss, atherosclerosis, cholestorol deposits,
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edema, poor urine processing
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(*@\\\*)
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(*@/// Glycine *)
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L-glycine
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- treatment for poor pituitary functioning
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- supplies creatine which is essential for muscle function
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(effective against muscular dystrophy)
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- treatment for hypoglycemia
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- stimulates glucagon which metabolizes glycogen into glucose
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- antacid
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- treatment for low blood pH
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- treatment for leucine imbalance-causing body odor and halitosis
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(*@\\\*)
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(*@/// Leucine *)
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L-taurine
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- nonessential amino acid
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- aids efficient conduction of electrical impulses
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along nerve pathways
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- anticonvulsant (esp in combo with glutamic, aspartic acids)
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(*@\\\*)
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(*@/// Glutathione *)
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L-Glutathione
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- tripeptide amino acid made of cysteine, glutamic acid and glycine
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- "triple threat" antiaging
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- antioxidant
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- anti-tumor agent
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- respiratory accelerator in the brain
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- used in the treatment of: allergies, cataracts, diabetes,
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hypoglycemia, arthritis
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- prevents some side effects of chemotherapy and X-ray radiation
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- protects against some harmful side-effects of cigarrette smoke
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and alcohol
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(*@\\\*)
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(*@/// Carnatine *)
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L-carnatine
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- newly discovered amino acid
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- aids stored fat -> energy conversion
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- helps: hypoglycemia, reduces angina attacks, diabetes,
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liver disease, kidney disease
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- deficiency causes heart tissue damage
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(*@\\\*)
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***************************** Article Separation ******************************
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Tyrosine is available in a free form base from Vitamin Research Products
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based in Mountain View, CA. call (415) 555-1212 for number. Suggestion
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would be to start with 100mg of tyrosine at first, then to increase (weekly)
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to 300mg. Overdose symptoms include irratibility. This will need to be taken
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with several precursor vitamins like C B-5,6,12, for uptake into the
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blood/brain barrier. This amino wil compete with protein uptake, so take it
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on an empty stomach - see the book 'Life Extension" D. Pearson & S. Shaw -
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***************************** Article Separation ******************************
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I wasn't trying to analyze the precise pharmacology of tryptophan's
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toxicity (FYI, it is due to a contaminant, "peak E": Science 1990;250:1707;
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NEJM 1990;323:357). Peak E is dimeric derivative of tryptophan; contaminants
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such as peak E, in tiny quantities, are virtually inevitable when amino acids
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are synthesized by chemical syntheses. That is why I believe it is acceptable
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to refer, albeit loosely, to "tryptophan" as the culprit.
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***************************** Article Separation ******************************
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Saved from Health-Infocom News from last fall:
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Volume 3, Number 35 November 4, 1990
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Update: Analysis of L-Tryptophan
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for the Etiology of Eosinophilia-Myalgia Syndrome
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In August 1990, CDC and the Food and Drug Administration proposed a
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structure for peak 97 (Figure 1A), the high performance liquid chromatographic
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(HPLC) peak that was most predictive of L-tryptophan (LT) lots associated with
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eosinophilia-myalgia syndrome (EMS) cases(1). This report updates those
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findings.
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Analyses of the product of LT and acetaldehyde show that the product is
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the di-L-tryptophan aminal of acetaldehyde (DTAA), with the methine bridge
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coupling the two tryptophan molecules across the indolenitrogens (Figure 1B)
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rather than the amino nitrogens (Figure 1A). Thissynthesized product has the
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same proton nuclear magnetic resonance(NMR) spectra, mass spectra, and HPLC
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chromatographic properties aspeak 97. [...]
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1. CDC. Analysis of L-tryptophan for the etiology of eosinophilia-myalgia
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syndrome. MMWR 1990;39:589-91.
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2. Reynolds WF, McClean S, Perpick-Dumont M, Enriquez RG.Improved 13C-1H shift
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correlation spectra for indirectly bonded carbons and hydrogens: the FLOCK
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sequence. Magn ResonChem 1989;27:162-9.
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3. Crofford LJ, Rader JI, Dalakas MC, et al. L-Tryptophan implicated in human
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eosinophilia-myalgia syndrome causes fasciitis and perimyositis in the Lewis
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rat. JClin Invest 1990;86:1757-63.
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Health InfoCom Network News Page 28
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****************************** Article Separation *****************************
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A safe stimulant which is not caffiene does exist and it available as
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a non-prescription drug from many health food stores. It's called
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Dimethylaminoethanol, or DMAE. It works pretty well as a stimulant and
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also increases levels of acetylcholine (it's a precursor). It also
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makes rats perform significantly better on maze tests, because the
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increased acetylcholine assists in some aspects of memory.
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Another way to decrease need for sleep is to raise brain levels of
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dopamine, which can be done by taking phenylalanine. It should be
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taken on an empty stomach (500 mg to 1 gram is a reasonable dose)
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with 1g vitamin C and 50 mg vitamin B-6 to assist in the conversion of
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phenylalanine to dopamine. Another way to take the phenylalanine
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is to place a small amount between the upper lip and gum about halfway back
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in the mouth. There are blood vessels there which go directly to the brain.
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If you're using this method, you should try a smaller dose (100 mg), as it is
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more effective when taken in this manner.
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Using these and other "safe" (i.e. adjusting the body's own chemicals
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rather than introducing something new; not necessarily safe but a priori
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a better bet than most traditional stimulants) I have been able to
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cut my need for sleep by 4 hours per day without discomfort for weeks at a
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time. I have no reason to believe that they would not be effective if
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used longer, but circumstances of class work seldom required me to cut
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sleep for longer periods than this.
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Be advised, however, that these methods will not be as powerful as,
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say, amphetamines or even high-dose caffiene, but they are not likely to
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mess you up either. But if you are trying to stay up for two nights
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to finish some huge project, you might be better off sticking with
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caffiene and cold showers.
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****************************** Article Separation *****************************
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Yes, aspartame is the methyl ester of phenylalanine and aspartic acid,
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two amino acids. According to Richard Wurtman of MIT, you can get
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increases in brain levels of phenylalanine if low-protein foods such
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as soft drinks are consumed on an empty stomach.
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The brain requires vitamins B-6 and C to convert phenylalanine into
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the natural stimulant noradrenaline and another important brain chemical,
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dopamine (which is also, among other things, a stimulant and euphoric)
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Thus even if you are taking no supplemental phenylalanine, you can
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still get beneficial effects on mood, etc., by taking C and B-6
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because your brain will become more efficient at converting the
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phenylalanine that is already present in your diet.
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Speaking of diets, phenylalanine also stimulates the release of
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cholecystokinin, which is the body's own appetite-suppressant,
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used to tell the brain when the stomach has had enough. So phenylalanine
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acts indirectly as an appetite-suppressant.
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Note that all of the effects of phenylalanine are greatly enhanced if
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it is taken either on an empty stomach or with low-protein foods,
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because various proteins compete with phenylalanine for transport
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across the blood-brain barrier.
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Dosage: 500mg to 1g phenylalanine, plus 1g C, 30 to 50mg B-6.
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WARNING: Do NOT use phenylalanine:
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*If you are using MAO inhibitors, unless they are the extremely
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selective types such as deprenyl (selegiline);
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*If you have a cardiac arrythmia;
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*If you have hypertension;
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*If you have phenylketonuria;
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*If you have a psychosis;
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*If you have a pigmented malignant melanoma-type cancer;
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*If you have a violent temper.
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If you are taking other stimulants such as phenylpropanolamine, ephedrine,
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or even, potentially, caffiene or theophylline, you should monitor your
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blood pressure carefully because there is a possiblity of blood pressure
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rise and other problems characteristic of adrenaline-like drug oversoda.
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***************************** Article Separation ******************************
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Phenylalanine and many other amino acid supplements are available
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mail-order from Vitamin Research Products, 2044 Old Middlefield Way,
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Mountain View, CA 94043 USA.
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Tryptophan is currently banned for sale in the US, due to the
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contamination scare of last year. The source of the contamination
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was found (an experimental genetically-engineered bacteria used by
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_one_ Japanese firm to manufacture the Tryptophan) but the FDA has
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still refused to lift the ban.
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***************************** Article Separation ******************************
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A little-known FDA ruling now allows the importation af a 3 month personal
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supply of drugs as long as they are regarded as safe in other countries.
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INTERLAB a mail order pharmacy was established in response to this new
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FDA ruling. Interlab carries a wide range of drugs for cognitive
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enhancement, life extension, and treatment of AIDS not available in
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America.
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All of the drugs briefly discuussed here can be pruchased without a
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prescription fron them. You can request a price sheet by writing to
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INTERLAB
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PO Box 587
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Newport Pagnell,
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Bucks, England
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You must include the following signed statement with your order:
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I hearby declare that the products I am purchasing are not for
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commercial resale. They are for my own personal use only. The supply
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ordered does not exceed 3 months usage and they are used with the consent
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of my physician.
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[signed]
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Some Highly regarded Chemicals include:
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HYDERGINE (Ergoloid Mesylates)- Improves mental function, prevents
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hypoxia and other damage to brain cells,increases blood supply to brain,
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enhances brain metabolism, slows deposit of aging pigment and other
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posistive effects
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PRECAUTIONS- Too large inital dose may cause nausea, gastric
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disturbance or headache. Non-toxic even at very high dosages.
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Contraindicated for individuals with acute or chronic psychosis.
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DOSE- 9-12 mg/Day
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COST- 100 x 5mg. oral tablets $39
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SULBUTIAMINE (Arcalion)- Described as being like hydergine only better.
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Facilitates wakefullness, inproves long-term memory, speeds reaction time
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.
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decreases anxiety.
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PRECAUTIONS- Do not exceed 3 x 200mg tablets at any time as may
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cause severe headaches. Other than this has no other adverse affects.
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DOSE- 2 x 200mg. tablets for 20 days.
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COST- 20 X 200 mg. tablets $11
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VASSOPRESSIN (Diapid)- A brain hormone released by the pituitary.
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Improve attention, concentration, memory and reacall.
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Cocaine, LSD, amphetamines, Ritalin, and Cylert(pemoline) cause depletion
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of
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vassopressin. Marijuana and alchohol inhibit the release of vassopressin.
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A
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Whiff of vassopressin can transform your experience in about 10 seconds
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when using these drugs as it is an application of the specific hormone
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being
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affected.
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PRECAUTIONS- Vassopressin occasionall produces the following side
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affects;
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runny nose, nasal congestion, itch or irritation of the nasal cavities,
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headach
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abdominal cramps and increased bowel movements. Safety during
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pregnancy unknown.
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DOSE- Comes in a nasal spray bottle. 2-4 whiffs 3-4 time2 a day will
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produce
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noticeable affects in seconds.
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COST- 12 ml. nasal spray $22
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Send $6 with order for shipping, $10 for accelerated shiping
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These are just a small cross section of the Interlab product line, but
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they
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have found favor with me and mine.
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You may find the newletter of the Cognitive Enhancement Research
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Institute helpful. Send $1.00 to
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CERI
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PO Box 483
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Santa Cruz, CA 96061
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****************************** Article Separation *****************************
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Some friends of mine make a vitamin formula that they sell to drug treatment
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clinics to combat the neurotransmitter deficit caused by stimulant abuse...
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It really works,a lot of people have been helped off cocaine with it.
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There are two separate preparations, an AM and PM formula,
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The PM formula used to contain tryptophan,but now does not,obviously,
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However,they have had some sucess with a formula that maximizes the conversion
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of dietary tryptophan into serotonin.
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Here is the formula...
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AM......
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L-tyrosine 250 mg.
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D,L phenylalanine 125 mg.
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Pantothenic acid 25 mg.
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PABA 25 mg.
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DMAE 25 mg.
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Rubidium Cl 25 mg.
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Tocopherol acetate 12.5 mg.
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Beta carotene 2.5 mg.
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Manganese (gluconate) 2.5 mg.
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Folic acid 0.1 mg
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Copper gluconate .125 mg
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Selenium .25 mg.
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PM.......
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Niacinamide (ascorbate) 250 mg.
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Taurine 50 mg.
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Magnesium oxide 50 mg.
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Pyridoxine 25 mg.
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Niacin 12.5 mg.
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Riboflavin 12.5 mg
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Zinc 2.5 mg.
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Beta carotene 2.5 mg.
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Chromium (GTF) .025 mg.
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Vitamin B12 .0125 mg.
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This is basically a neurotransmitter boosting formula and benefits those
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who dont have a drug abuse problem too.
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I was recently lucky enough to be given several ounces of pure DMAE
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(dimethylaminoethanol) and boy,is it ever a lot better than the Twinlab
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stuff,which I had previously been using...
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I use it in combination with tyrosine in the morning and it has dramatically
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improved my memory (and an interesting sideffect is the induction of lucid
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dreams...)
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A good source for DMAE are the AIDS buying clubs that have popped up in
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major cities..(although thats not where I got this..)
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For anyone interested in neurotransmitter precursor supplementation
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(DMAE,a relative of choline,is a precursor of acetylcholine)
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this one REALLY works..
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