355 lines
18 KiB
INI
355 lines
18 KiB
INI
Contac CoughCaps are a very good source of DM, they contain nothing bbut
|
|
30mg DM in each cap. Working dosage for me (6'1" 210-220 lbs) has been 900mg
|
|
DM or 30 tablets. This might be far more than you will need, I suggest
|
|
determining how much Robotussin you would normally take in oreder to achieve
|
|
the desired effects and convert across (100ml Robo==300mg DM==10 CoughCaps).
|
|
|
|
Once you have figured out your dosage it is best to take the tablets over
|
|
the course of an hou. You do not want them to clump up and dissolve slowly
|
|
in one place, In fact it might even be better to take them with some food.
|
|
|
|
Just be careful with alcohol intake during this time, while it is true that
|
|
your alcohol levels will effect the intensity and depth of the stone (the
|
|
more alcohol in your system the higher you get {tres' synergistic}) higher
|
|
lavels of alcohol can also make you feel naseaus to the point of vomiting
|
|
(mind you this dosn't last all that long, but it is unpleasent [as is any
|
|
vomiting on psychedelics])
|
|
|
|
Smoking a joint or three will also have a synergistic effect, as will eating
|
|
mushrooms or chewing morning glory seeds (haven't found any acid in years :(
|
|
).
|
|
|
|
ahaigh@unixg.ubc.ca
|
|
|
|
=============================================================================
|
|
|
|
This is what I have found, your mileage will vary according to what
|
|
else you are taking at the time.
|
|
|
|
300mg DM == light buzz, similiar to 50-100yg lsd
|
|
|
|
600mg DM == stronger, similiar to 100-250ug lsd
|
|
|
|
900mg DM == very strong, full spectrum of hallucinations
|
|
equvalent to 300-600yg lsd
|
|
|
|
These levels will have different effects on different people, and at different
|
|
times for the same person, depending on what other drugs you are taking at the
|
|
time. Personally I combine 900mg DM with alcohol, marijuana, and morning glory
|
|
seeds. This I don't recommend for everyone, especially people unexperienced with
|
|
psychedelics. Start off low and work your way up. And be careful, too much DM as well as too much alcohl at the same time will make you barf.
|
|
|
|
ahaigh@unixg.ubc.ca
|
|
|
|
=============================================================================
|
|
|
|
Okay, for anyone who wants to play around with dextromethorphan, this
|
|
might be of use to you. Maybe an FAQ is needed?
|
|
|
|
First, the biochemical side of things.
|
|
Dextromethorphan acts as a cough suppressant via its agonist (activating)
|
|
activity at mu-opioid receptors. Unlike codeine, it does not seem to
|
|
activate other opioid receptors, except for the sigma receptor (see below).
|
|
|
|
As far as its "other" effects, DXM is in the same class as ketamine, PCP,
|
|
MK-801, and several other NMDA open channel blockers / sigma opioid ligands.
|
|
|
|
The sigma opioid receptor's function is unknown but it may be implicated
|
|
in schizophrenia. Sigma opioid agonists produce both the positive and the
|
|
negative symptoms of schizophrenia, unlike dopaminergics which produce only
|
|
the positive symptoms.
|
|
|
|
The NMDA receptor is a fast ion-channel receptor which is normally activated
|
|
by the excitory amino acids and possibly potentiated by glycine. There is
|
|
a second NMDA receptor subtype in the cerebellum (this may account for DXM's
|
|
perceived effect on motion). NMDA receptors probably exist in several
|
|
different subtypes. DXM, ketamine, PCP, and other similar chemicals act as
|
|
"open channel blockers." Upon the opening of the NMDA channel, the chemicals
|
|
enter the channel and block ion transfer. DXM is a non-competitive blocker.
|
|
|
|
In addition to this, there is a second "PCP2" binding site (the PCP1 site
|
|
is the NMDA open channel block site). This may be a biogenic amine reuptake
|
|
complex. If so, then these class of chemicals may act as reuptake inhibitors.
|
|
The role of the PCP2 site is poorly understood.
|
|
|
|
I don't know offhand the binding of DXM to sigma, PCP1, and PCP2 in comparison
|
|
to ketamine, MK-801, and PCP.
|
|
All of these drugs are being studied for their effects in preventing damage
|
|
to the brain during siezure.
|
|
|
|
In terms of effects on humans, described effects include dissociative
|
|
anaesthesia, mild hallucinations, enhanced response to music (including
|
|
highly pleasurable responses), and disturbances in motion. Nausea can
|
|
occur. DXM has some stimulant effects.
|
|
|
|
In terms of sources, DXM is available over-the-counter in many countries
|
|
in tablet form. Robitussin Maximum Strength Cough (not Robitussin DM)
|
|
contains DXM with nothing else (except a little alcohol). Robitussin DM
|
|
also contains an expectorant which should not be taken in high doses.
|
|
Dose of Robitussin Maximum Strength Cough is two to five full "shots"
|
|
using the shot glass that comes with the bottle.
|
|
|
|
The usual warnings apply. Additionally, prolonged use of DXM can and has
|
|
led to psychosis similar to PCP-induced psychosis. Individual differences
|
|
in NMDA receptors may be at work here, but you're still potentially at
|
|
risk. I personally wouldn't mix DXM with anything.
|
|
|
|
--
|
|
| Bill White +1-614-594-3434 | bwhite@oucsace.cs.ohiou.edu |
|
|
| 31 Curran Dr., Athens OH 45701 | bwhite@bigbird.cs.ohiou.edu (alternate) |
|
|
| SCA: Erasmus Marwick, Dernehealde Pursuivant, Dernehealde, Middle Kingdom |
|
|
|
|
=============================================================================
|
|
|
|
From: Nathan.Bowen@mixcom.mixcom.com (Nathan.Bowen)
|
|
Newsgroups: alt.drugs
|
|
Subject: Re: Robitussin
|
|
Message-ID: <1993Apr13.170256.10562@mixcom.com>
|
|
Date: 13 Apr 93 17:02:56 GMT
|
|
|
|
In <C5Dvq9.A40@news.cso.uiuc.edu> jroberts@ux4.cso.uiuc.edu (jroberts@ux4) writes:
|
|
|
|
>This may seem like a question that has been dragged through the mud, but
|
|
>actually I have not seen too much information on Robitussin. When it is
|
|
>mentioned, it is not made clear exactly what type of trip it gives, just that
|
|
>it gives a trip. Is it hallucinogenic? Euphoric? Alcohol-like? How long
|
|
>does it last? Any side effects? And what ever came of the evaporating
|
|
>everything but the Dextromethorphan? What is the usual dosage (6-8 oz.'s?)?
|
|
>Well, any responses would be appreciated.
|
|
|
|
The trip is more of a buzz to my experience, and to that of my
|
|
friends. I have been told that high dosages <High meaning 750-900mg>
|
|
produce hallucinogenic effects similar to 'shrooms and LSD. I cannot
|
|
deny this, because my highest dosage was 360, and most people who use it
|
|
regularly have done 240 to the best of my knowledge. The usual dosage,
|
|
then, is nonexistant - everyone has their own idea of how much is
|
|
enough. Anything less than 240 will probably not do much more than make
|
|
you a bit dizzy, groggy, and tired. 240mg would be a 4 ounce bottle of
|
|
Robitussin-DM, but I would recommend avoiding this, because of the
|
|
Guaifenesin it contains. You may want to go straight to 360mg, which is
|
|
found in most "Maximum Strength" cough medicines, such as a certain
|
|
formula of Vicks and Robitussin Maximum Strength. These also contain no
|
|
guaifenesin, but usually do contain alcohol. If you can get to Canada,
|
|
or have friends there who can mail things to you, you may want to
|
|
consider Contac CoughCaps. They are, to my knowledge, little pills
|
|
containing nothing but 30mg of DM HBr that are sold just about
|
|
everywhere - with the exception of the USA.
|
|
|
|
The experiences are quite unlike other mild drugs <alcohol,
|
|
which you mentioned, for instance> at the mild dosages. No one has
|
|
recently reported here any visual hallucinations at the standard 4oz
|
|
maximum strength cough syrup 360mg DM doses. On the other hand, most of
|
|
us agree that our thought patterns are shifted noticeably, and there is a
|
|
distinct difference to the sounds of music. Another effect that has
|
|
been confirmed by several people <including myself, to a tremendous
|
|
degree>, is the sensation that you're slurring your speech. I have
|
|
actually carried on conversations with people while on heavy DM buzzes,
|
|
and felt that I was slurring my speech uncontrollably, but I've been
|
|
told that, in fact, the only thing that might have given me away was the
|
|
"Pleasant Tasting Syrup" on my breath.
|
|
|
|
Speaking for myself, I've noticed some really neat balance
|
|
sensations/time distortions. A friend of mine who was kind of hanging out
|
|
around my house while I was buzzing on DM suggested that I jump up and down.
|
|
He's always been rather drug-free, and I wasn't preapred to take such a
|
|
silly suggestion without some experience to back it up, but I finally gave
|
|
in. It was great, and I kept it up for a few minutes. It's hard to explain,
|
|
but I found that I landed a few seconds after I hit the ground. I also took a
|
|
ball-like object and tossed it into the air to myself repeatedly. It,
|
|
too, took its time about landing. Kind of novel, really.
|
|
|
|
I have a collection of relevant articles on Robitussin/DM use
|
|
around here somewhere, I'll clean it up and post it this week.
|
|
|
|
-Nathan nathan.bowen@mixcom.com
|
|
|
|
|
|
=============================================================================
|
|
|
|
From: pearl@crl.com (Peter Helyar)
|
|
Newsgroups: alt.drugs
|
|
Subject: Re: Tussin can be BAD!
|
|
Date: 27 Sep 1993 19:33:24 -0700
|
|
Message-ID: <2887pk$d71@crl.crl.com>
|
|
|
|
In article <2884sg$jjf@news.u.washington.edu> lamontg@cs.washington.edu writes:
|
|
>jane@unislc.slc.unisys.com (Jane Ellis) writes:
|
|
>
|
|
(long description of bad Tuss experience deleted)
|
|
|
|
>i'm wondering to myself how much this whole reaction was related to
|
|
>simply set and setting.
|
|
|
|
My take on this one is that there is the potential for some significant
|
|
adverse effect in some people. My own experience (posted a week or so ago)
|
|
included what I interpret as a fairly severe histamine reaction. It might be
|
|
interesting to find out if Jane Ellis has other problems with histamines -
|
|
for instance hay fever.
|
|
|
|
A friend of mine who happens to be a nurse is the one who first proposed this
|
|
theory. I would very much appreciate anything anyone here has to offer in the
|
|
way of more educated viewpoints on the subject. If it gets posted soon enough,
|
|
I might even get to read it before I experiment with the combination of 540mg
|
|
DM and 50mg Benadryl which my nurse friend suggested.
|
|
|
|
In the meantime, it might be wise for any sufferers of hay fever to move very
|
|
carefully with this stuff, in case there is a corelation.
|
|
|
|
|
|
--
|
|
/^v^\ |There are no rehearsals - live like you mean it already.
|
|
( 0 0 ) |
|
|
uuuu U uuuu | pearl@crl.com (this is more reliable)
|
|
Pearlie was here | pearl@cyberden.sf.ca.us
|
|
|
|
=============================================================================
|
|
|
|
Message-ID: <005302Z25011994@anon.penet.fi>
|
|
Newsgroups: alt.drugs
|
|
From: an45874@anon.penet.fi
|
|
Date: Tue, 25 Jan 1994 00:45:56 UTC
|
|
Subject: Dextromethorphan Experience
|
|
|
|
[text deleted -cak]
|
|
|
|
I've included a few references, Read and Learn. The products I took
|
|
contained dextromethorphan as an exclusive active ingredient. I included
|
|
the info in guaifenesin because you're likely to come across it in reading
|
|
labels. Note what Merk has to say about its efficacy.
|
|
|
|
Drug Interaction: One of the packages boldly warns about combining
|
|
dextromethorphan and any MAO inhibitor. Pay attention to it.
|
|
|
|
From _The Merk Manual_ 16th ed. [My comments/edits in brackets[]]
|
|
Dextromethorphan: a cogener of the narcotic analgesic levorphanol,
|
|
possesses no significant analgesic or sedative properties, does not repress
|
|
respiration in usual doses, and is nonaddictive. No evidencs of tolerance
|
|
has been found during long-term use. The average dosage for adults is 15
|
|
to 30 mg. t to 4 times/day. given as a tablet or syrup; for children 1
|
|
mg/kg/day is given in divided doses. Extremely high doses may depress
|
|
respiration [I have no idea (and it didn't indicate) what 'extremely high'
|
|
means]. [It acts to] inhibit or supress the cough reflex by depressing the
|
|
medullary cough center or associated higher centers.
|
|
|
|
Guaifenesin: is the most commonly used expectorant in OTC cough remedies.
|
|
It has no serious side effects, but there is no clear evidence for its
|
|
efficacy.
|
|
|
|
From _Dorland's Pocket Medical Dictionary_ (23rd ed.):
|
|
analgesic: ... an agent that relieves pain ...
|
|
cogenor: congenor
|
|
congenor: ... a chemical compound closely related to another in composition
|
|
and exerting similar or antagonistic effects, or something derived from
|
|
the same source of stock.
|
|
dextromethorphan: a synthetic morphine derivative (C18H25NO) used as an
|
|
antitussive (cough supressant) in the form of the hydrobromide salt.
|
|
guaifenesin: the glyceryl ester of guaiacol (C10H14O4), used as an
|
|
expectorant.
|
|
levorphanol: a narcotic analgesic (C17H23NO).
|
|
morphine: the principal and most active alkaloid of opium (C17H19NO2),
|
|
its hydrochloride and sulfate salts are used as narcotic analgesics.
|
|
narcotic: a drug that produces insensibility or stupor, especially an opioid.
|
|
|
|
8 teaspoons = 1 ounce approx. (For while you're standing there reading labels)
|
|
Information taken from references is included without permission.
|
|
-------------------------------------------------------------------------
|
|
To find out more about the anon service, send mail to help@anon.penet.fi.
|
|
Due to the double-blind, any mail replies to this message will be anonymized,
|
|
and an anonymous id will be allocated automatically. You have been warned.
|
|
Please report any problems, inappropriate use etc. to admin@anon.penet.fi.
|
|
|
|
=============================================================================
|
|
|
|
Newsgroups: alt.drugs
|
|
From: ez029006@othello.ucdavis.edu (Jon )
|
|
Subject: Harpers Robo article
|
|
Message-ID: <CKMo76.GzA@ucdavis.edu>
|
|
Date: Thu, 3 Feb 1994 02:57:05 GMT
|
|
|
|
The June 1993 Harper's magazine has a cool little article about
|
|
robo-ing. I believe they got it from the Spring issue
|
|
of Pills-a-go-go, whatever that is. The article is by Jim Hogshire,
|
|
and it is pretty acurate. He tells of his adventures following
|
|
drinking eight ounces of the magic elixir. I especially liked the
|
|
part about being a reptile.
|
|
|
|
So if you are at all interested in robo, go to the library and
|
|
give it a read.
|
|
|
|
--Jon
|
|
|
|
=============================================================================
|
|
|
|
Date: Wed, 17 Nov 1993 14:45:30 +1000
|
|
From: Stuart McLean <S.McLean@PHARM.UTAS.EDU.AU>
|
|
Subject: Re: Cough Medicine abuse
|
|
Sender: Drug Abuse Education Information and Research <DRUGABUS@UMAB.BITNET>
|
|
Message-id: <01H5E8FWZG8I8ZE7R4@YMIR.Claremont.Edu>
|
|
|
|
Another important aspect of dextromethorphan is that about one in ten
|
|
people have an inherited deficiency in the enzyme which metabolises this
|
|
drug (by O-demethylation). This proportion may be different for
|
|
non-European ethnic groups.
|
|
|
|
The consequence is that the effects of dextromethorphan are likely to be
|
|
more intense and more prolonged in these individuals than in the rest of
|
|
the population. Each individual's capacity to metabolise dextromethorphan
|
|
can only be determined by chemical analysis.
|
|
|
|
Ref. Schmid et al. Clin Pharmacol Ther 1985; 38(6): 618-624.
|
|
|
|
___________________________________________________________________
|
|
Stuart McLean Telephone (002) 202 199
|
|
School of Pharmacy Facsimile (002) 202 870
|
|
University of Tasmania International callers:
|
|
GPO Box 252C, Hobart 7001 please use 61 02 in place of 002
|
|
Australia Email <S.McLean@pharm.utas.edu.au>
|
|
|
|
=============================================================================
|
|
|
|
AUTHOR: Schmid B; Bircher J; Preisig R; Kupfer A
|
|
TITLE: Polymorphic dextromethorphan metabolism: co-segregation of
|
|
oxidative O-demethylation with debrisoquin hydroxylation.
|
|
SOURCE: Clin Pharmacol Ther (DHR), 1985 Dec; 38 (6): 618-24
|
|
LANGUAGE: English
|
|
COUNTRY PUB.: UNITED STATES
|
|
ANNOUNCEMENT: 8603
|
|
PUB. TYPE: JOURNAL ARTICLE
|
|
ABSTRACT: Dextromethorphan hydrobromide, 25 mg po, was given to 268
|
|
unrelated Swiss subjects to study urinary drug and
|
|
metabolite profiles. Rates of O-demethylation yielding the
|
|
main metabolite dextrorphan were expressed by the urinary
|
|
dextromethorphan/dextrorphan metabolic ratio. We found a
|
|
bimodal distribution of this parameter in our population
|
|
study, which indicates that there are two phenotypes for
|
|
dextromethorphan O-demethylation. The antimode at a
|
|
metabolic ratio of 0.3 separated the poor metabolizer (PM; n
|
|
= 23; prevalence of 9%) from extensive metabolizer (EM)
|
|
phenotypes. Urinary output of dextrorphan was less than 6%
|
|
of the dose in all PMs and was 50% in the 245 EMs. Pedigree
|
|
analysis of 14 family studies revealed an autosomal-
|
|
recessive transmission of deficient dextromethorphan O-
|
|
demethylation. In these families, 37 heterozygous genotypes
|
|
could be identified; however, through use of the urinary
|
|
drug and metabolite analysis it was not possible to identify
|
|
the heterozygous genotypes within the EM phenotype group. Co-
|
|
segregation of dextromethorphan O-demethylation with
|
|
debrisoquin 4-hydroxylation was also studied. Complete
|
|
concordance of the two phenotypic assignments was obtained,
|
|
with a Spearman rank correlation coefficient of rs = 0.78 (n
|
|
= 62; P less than 0.0001) for dextromethorphan and
|
|
debrisoquin metabolic ratios. Presumably the two drug
|
|
oxidation polymorphisms are under the same genetic control.
|
|
Thus the innocuousness and ubiquitous availability of
|
|
dextromethorphan render it attractive for worldwide
|
|
pharmacogenetic investigations in man.
|
|
MESH HEADINGS: Dextromethorphan--urine (UR)/metabolism (*ME); Dextrorphan--
|
|
urine (*UR); Levorphanol--analogs & derivatives (*AA);
|
|
Morphinans--urine (*UR); Administration, Oral; Adult; Aged;
|
|
Chromatography, High Pressure Liquid; Hydroxylation; Middle
|
|
Age; Pedigree; Phenotype; Female; Human; Male; Support, Non-
|
|
U.S. Gov't
|
|
CHEMICAL SUBS: 0 (Morphinans); 125-71-3 (Dextromethorphan); 125-73-5
|
|
(Dextrorphan); 77-07-6 (Levorphanol)
|
|
STANDARD NO.: 0009-9236
|