75 lines
3.2 KiB
Plaintext
75 lines
3.2 KiB
Plaintext
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Methamphetamine synthesis:
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The major problem with methedrine synthesis is procuring the precursors.
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Phenyl-2-propanone is the most direct precursor to my knowledge and is
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(unfortunately?) at Schedule III controlled substance. It has no
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pharmacological activity and yet the DEA saw fit to regulate it around 1975.
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The first synthesis I will give uses this in as a starting material. Actually
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it is still possible to find this substance tucked away in store rooms in many
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universities that presumably purchased the compound before it was controlled.
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A friend of mine came across 500 mls made by Eastman Kodak in the stock room at
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Princeton. I purchased 100 mls when I lived in England many years ago and did
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my first run using it. The reaction can be completed in about 6 hours giving
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about 60% yield; I am a biologist, not a chemist so someone who knew what they
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were doing could probably improve on that.
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Reagents:
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1-phenyl-2-propanone 20 gm
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EtOH 100 ml
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Methylamine 40% in water 100 mls
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Aluminum foil 20 gm
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Mercury II Chloride 150 mg
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Reflux above mixture with stirring for two hours in 500 ml round bottom flask.
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Concentrate rxn mix under reduced pressure at room temp. Pour on to ice cold
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KOH sol'n (60 gm in about 200 mls water). At this step, big problems can
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happen. A great deal of heat is liberated. Add very *slowly* and keep in an
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ice bath. Heat will degrade your product in to god knows what and just might
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end up on the ceiling, if you are not careful.) Extract solution w/ 125 x 3 mls
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ethyl ether. Recover organic layer. Extract ether with 3N HCl 25 x 3 mls.
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Add 30 mls 6 N NaOH solution (cold) to acid solution, add more if solution is
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not very basic. Extract basic solution with 25 x 3 mls of ether. Dry over
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anhydrous sodium sulfate, filter. Rotovap. off ether (distill under reduced
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pressure if you want to get fancy but it is not absolutely necessary) and
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redissolve in anhydrous ether, 100-200 mls. Bubble dry HCl gas (made my
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dropping conc. HCl onto conc. Sulfuric acid) through mixture and methedrine HCl
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should ppt. as white fluffy powder.
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Filter off meth and repeat for second and third crop. Keep the first for
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yourself and sell the rest. The subsequent crops can be pink or purplish and
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are still effective pharmacologically but they are not very clean. I hope this
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was what you are after. If it is, drop me another line and I will give you the
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synthesis for the phenyl-2-propanone. That synthesis is much nastier, more
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dangerous and takes a lot more expertise.
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Now the pitch: Methedrine is a heinous chemical. I can handle most drugs,
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except meth. I first did this synthesis for kicks. It quickly became a lot
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more than that. I started mainlining it and things got really out of hand. I
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would up in the emergency room twice, the psych ward once, got kicked out of
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Johns Hopkins University lost my job at NIDA and very nearly killed myself and
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a bunch of other people. Actually, if you want more information, I would much
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rather talk about that-- if only to discourage.... well, maybe just to warn
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people to be *very* careful when dabbling in CNS stimulants. Speed may not
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kill but it can fuck you up very bad.
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