81 lines
4.7 KiB
Plaintext
81 lines
4.7 KiB
Plaintext
Do yoy wanna make PCP(Angel Dust)? The following formulas A,B and C
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tells you how. Formula D is for a related compound with similar effects.
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The substances give an eufforic effect by an oral dosage of 5 to 10mg.
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The formulas produce the free base of the compounds, but for human use
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the salt is preferred. To convert the free base to its corresponding salt
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just dissolve it in isopropanolic hydrogenchloride and precipitate the
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salt by addition of ether. Another way is to dissolve the free base in
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ether and adding an excess of hydrogenchloride to precipitate the salt.
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The 1-(1-phenylcyclohexyl)piperidine hydrogenchloride salt melts at 243-
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244 degrees C. The hydrogenchloride salt of formula D melts at 236-
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237 degrees C.
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A
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A solution containing one mole of magnesium bromide etherate
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(prepared by reacting 25g of magnesium with 188g of ethylenedibromide
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in 400ml of ether) is added to a solution of phenyl lithium prepared
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from 13.9g of lithium and 160g of bromobenzene in 500ml of anhydrous
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ether. The resulting mixture is refluxed with stirring for several
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hours and then a solution of 154g of 1-(1-piperidino)-cyclohexane-
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carbonitrile in 500ml of dry ether added. The reaction mixture is
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refluxed and stirred for 18 hours and then treated with sufficient
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satureded ammoniumchloride solution to just produce a clear ether
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layer. After filtration of the solids the ether is distilled and
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the residual 1-(1-phenylcyclohexyl)piperidine so obtained
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distilled in vacou; b.p 109 degrees at 0.25mm. On rubbing and
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stirring the oily distillate the product crystallizes. After
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recrystallization from ligroin the PCP melts at 45-46 degrees.
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B
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A mixture consisting of 170g of piperidine, 220g of cyclohexanone
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and 750ml of benzene is subjected to azeotropic distillation until
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the the evolution of water ceases. The solution is subjected to vacuum
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distillation to obtain the desired N-(1-cyclohexenyl)piperidine; b.p.
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105 degrees at 8mm.
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190g of p-toluenesulfonic acid monohydrate is suspended in 250ml toluene
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and the mixture heated under a water trap until all the water has been
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removed. 165g of N-(1-cyclohexenyl)piperidine in 500ml of ether is added
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to the toluene solution of p-toluenesulfonic acid at about 0-5 degrees.
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A solution of approximately one mole of phenyl magnesium bromide
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(prepared from 157g of bromobenzene and 24g of magnesium) in 750ml
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of ether is added to the slurry of the tosylate salt of N-(1-cyclohexenyl)-
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piperidine with stirring at about 5 degrees. The reaction mixture is stirred
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for 30 minutes after the addition has been completed and decomposed by the
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addition of an excess of saturated ammonium chloride and koncentrated
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ammonium hydroxide. The ether layer is removed, dried over potassium
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carbonate and the ether destilled. Distillation of the residue in vacuo
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yields the desired 1-(1-phenylcyclohexyl)piperidine; b.p. 135-137 degrees
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at 1mm; m.p. 46-46.5 degrees.
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C
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59g of magnesium is added to 230g of 1,5-dibromopentane in 2 liters of
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ether and the mixture stirred and refluxed for three hours. 151g of
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N-benzoylpiperidine is added to the solution of pentamethylene-bis-
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magnesiumbromide and the ether removed by distillation untill the
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temperature in the reaction vessel reaches about 83 degrees C. The
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reaction mixture is stirred at this temperature for sixteen hours,
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cooled and then treated with sufficient ammoniumhydroxide and sauterated
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ammoniumchloride to dissolve all the precipitate. The solution is diluted
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with 2 liters of ether and the ether layer removed by decantation.
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The ether layer is washed, dried over sodiumhydroxide and then the
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ether distilled. The residue is distilled in vacuo to obtain the
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desired 1-(1-phenylcyclohexyl)piperidine; bp 128-134 degrees C. at
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0.8mm Hg.
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D
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A mixture consisting of 100g of anhydrous ethylamine and 220g of
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cyclohexanone is allowed to stand for 16 hours. The reaction mixture
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is shaken thoroughly with solid potassiumhydroxide and the oil layer
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removed by decantation. Distillation of the oil layer in vacou yields
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the desired N-cyclohexylidene ethylamine; bp 68-75 degrees C. at 22mm Hg.
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A solution of phenyllithium prepared from 11.2g of lithium and 76ml of
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bromobenzene in 500ml of ether is added dropwise at 0 degrees C. to
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a solution of 51g of N-cyclohexylidene ethylamine in 500ml of ether.
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After the addition has been completed, the reaction mixture is stirred
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for one hour and then decomposed by the addition of water. The ether
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layer is removed, washed with water and dried. The ether is evaporated
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and the residue distilled in vacuo to obtain the desired
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(1-phenylcyclohexyl)-ethylamine; bp 104-108 degrees C. at 2.5mm Hg.
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