56 lines
1.8 KiB
Plaintext
56 lines
1.8 KiB
Plaintext
From: pjordan@cab020.cs.ualberta.ca (Peter Jordan)
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Newsgroups: rec.drugs.misc,alt.drugs.chemistry,sci.chem
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Subject: Morphine... extraction circa 1907 !
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Date: 15 Sep 1995 01:41:56 GMT
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BEGIN QUOTE
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MORPHINE or MORPHIA C17H19NO3 [ maybe not correct ]
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<SKIP>Solubility stuff</SKIP>
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Occurs in opium, being known in an impure state as
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_Magisterium opii_ in the seventeenth century, and was first isolated
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in 1816 by Serturner (Gilb. Ann. 55, 61 ; 57, 192 ; 59, 50).
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Dott (Pr. E. 12, 189) found in a sample of opium that half the morphine
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was present as meconate and half as sulphate. It also occurs in
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_Eschscholtzia californica_ (Baudet a. Adrian, C.C. 1889, 197), and
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in hops.
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[ Hmmm, I wonder about that .. this is OLD stuff. ]
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Preperation.--1. Opium is macerated with water at 38 degrees, the
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extract evaporated with CaCO3 to a small bulk, and then mixed with CaCl2.
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The liquid is filtered from ppd. calcium meconate, and evaporated.
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It first deposits calcium meconate, and afterwards a mixture of the
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hydrochlorides of morphine and codeine. These crystals are dissolved in
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water and treated with ammonia, which ppts. morphine, leaving codeine
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in solution (Robiquet a. Gregory, A. 5, 87 ; 7, 261).--2. The aqueous extract
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of opium is boiled with lime, and the filtrate boiled with NH4Cl,
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which ppts. morphine (Mohr, A. 35, 120).
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<SKIP>Pages of neato stuff.</SKIP>
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APOMORHINE C17H17NO2. Formed by heating ....
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END QUOTE
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SOURCE:
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H. Forster Morley and M. M. Pattison Muir
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Assisted by Eminent Contributors
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in four volumes .. Vol. III
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_Watts' Dictionary of Chemistry_
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(revised and entirely rewritten (in 1888)
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Longmans, Green, and Co.
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39 Paternoster Row, London
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New York and Bombay
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1906
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Peter Jordan (I just happened to see it on the shelf on my way out of the lib.)
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--
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http://ugweb.cs.ualberta.ca/~pjordan/
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