166 lines
6.5 KiB
Plaintext
166 lines
6.5 KiB
Plaintext
Merritt JC, Crawford WJ, Alexander PC, Anduze AL, Gelbart SS: Effect of
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marihuana on intraocular and blood pressure in glaucoma. Ophthalmology
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1980; 87:222-28
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Chang AE, Schilling DJ, Stillman RC, Et Al: Delta-9-tetrahydrocannabinol
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as an antiemetic in cancer patients receiving high dose methotrexate.
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Ann Intern Med 1979; 91:819-24
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Ungerleider JT; Andrysiak T: Therapeutic issues of marijuana and THC
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(tetrahydrocannabinol). Int J Addict 1985 May; 20(5):691-9
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I obtained these citations from the Pilot Drug Evaluation Staff
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Center for Drug Evaluation and Research
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Food and Drug Administration
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HFD-007
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Rockville, MD 20857
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Ask for the PDES Master Bibliography Marijuana/THC, Therapeutic Uses
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(9 pages with abstracts)
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Tod Mikuriya, M.D.
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=============================================================================
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From: ebrandt@jarthur.cs.hmc.edu (Eli Brandt)
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Newsgroups: alt.drugs
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Subject: Re: Medicinal Uses of Cannabis
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Date: 17 Nov 1993 05:52:53 GMT
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Message-ID: <2cce7l$d2q@jaws.cs.hmc.edu>
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In article <wortCGM9Lz.G71@netcom.com>, Ben Chesley <wort@netcom.com> wrote:
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>Besides the calming of nerves <hehe> I really can't think of alltogether
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>too many other uses... I could be wrong though, but those are the most
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>well known.
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Here's something I posted somewhere else:
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--------------------
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[somebody else said something]
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[I said:]
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The claim is something of an overstatement, mostly in the word
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"proven". However, it's nowhere near as whacked-out as you might
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think. I hate to inject a truckload of references, but actually I
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don't. So here you go.
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Nausea: pretty well known; I'll list a only few refs.
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Vinciguerra, Moore and Brennan, "Inhalation Marijuana as an
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Anti-emetic for Cancer Chemotherapy", NY State J. Med. 88
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(Oct 1988): 525-527.
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[78 percent of 56 patients with nausea resistant to standard
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drugs became symptom-free]
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Chang et al., "Delta-9-THC as an Antiemetic in Cancer Patients
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Receiving High-dose Methotrexate", Ann. Internal Med. 91
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(1979): 819-824.
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[smoked THC more effective than oral, among other findings]
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Doblin and Kleiman, "Marihuana as Anti-emetic Medicine: A Survey of
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Oncologists' Attitudes and Experiences", J. Clin. Oncology 9
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(191): 1275-1280.
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[44% had recommended illegal use of marijuana; half would
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prescribe it if it were legal]
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Glaucoma:
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Hepler and Frank, "Marihuana Smoking and Intraocular Pressure", JAMA
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217 (1971): 1392.
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[reduces IOP in patients with glaucoma]
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Hepler, Frank, and Petrus, "Ocular Effects of Marijuana Smoking", in
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_The Pharmacology of Marijuana_, ed. Braude and Szara. (NY:
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Raven, 1976), vol.2: 815-824.
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[no tolerance to IOP effect apparent over 94-day study]
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Multiple sclerosis: (mostly case studies)
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Clifford, "THC for Tremor in Multiple Sclerosis", Ann. Neurology 13
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(1983): 669-671.
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[case study of treatment of resistant and disabling tremor]
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Meinck et al., "Effects of Cannabinoids on Spasticity and Ataxia in
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Multiple Sclerosis", J. Neurology 236 (1989): 120-122.
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[case study of marijuana for "motor and sexual handicaps"]
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Lyman et al., "Delta-9-THC: A Novel Treatment for Experimental
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Autoimmune Encephalitis", J. Neuroimmunology 23 (1989): 73-81.
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[THC increased survival of this MS model from 2% (placebo)
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to 95%. May *prevent* progression of MS!]
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AIDS: (effects on appetite are well known)
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Migraines: primarily anecdotal reports, but see:
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Volfe, Dvilansky, and Nathan, "Cannabinoids Block Release of
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Serotonic from Platelets Induced by Plasma from Migraine
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Patients", Int'l. J. Clin. and Pharm. Res. 5 (1985): 243-246.
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"spasms": (also speculative)
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Malec, Harvey, and Cayner, "Cannabis Effect on Spasticity in Spinal
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Cord Injury", Arch. Physical and Med. Rehab. 63 (March
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1982): 116-118.
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[half of the patients surveyed used marijuana for muscle
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spasms]
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Maurer et al., "Delta-9-THC Shows Antispastic and Analgesic Effects
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in a Single Case Double-Blind Trial", Eur. Arch. Psychiatry
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and Clin. Neurosci. 240 (1990): 1-4.
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[oral THC comparable in efficacy to codeine, but more
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effective at reducing muscle spasms]
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labor pains: anecdotal, unless you consider nineteenth-century use.
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But as to analgesia in general:
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Noyes, Brunk, Avery, and Canter, "The Analgesic Properties of
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Delta-9-THC and Codeine", Clin. Pharm. and Therapeutics 18
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(1975): 84-89.
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[20 mg THC approximately as effective as 120 mg codeine in
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patients with advanced cancer]
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Milstein, MacCannel, Karr, and Clark: "Marijuana-produced Changes in
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Pain Tolerance: Experienced and Non-experience Subjects",
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Int'l. Pharmacopsychiatry 10 (1975): 177-182.
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[analgesic effect greater in more experienced users]
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> I have heard of its benefits in relieving SOME pain, but I find the claim
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>that it might help asthma to be pretty laughable.
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Laugh not; THC is an effective bronchodilator. Of course, smoking
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plants is probably less than optimal for asthmatics. Inhalation
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would be better, but THC itself appears to be an irritant by this
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route.
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Smoked THC vs. inhaled isoproterenol: Tashkin et al., "Effects of
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Smoked Marijuana in Experimentally Induced Asthma", Amer.
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Rvw. of Respiratory Disease 112 (1975): 377-386.
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[smoked THC had slower, longer effect]
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Inhaled THC vs. isoproterenol: Vachon et al., "Airways response to
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Aerosolized Delta-9-THC: Preliminary Report", in _The
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Therapeutic Potential of Marijuana_, ed. Cohen and Stillman.
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[inhaled THC had faster, shorter effect]
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The flyer in question didn't mention epilepsy, but I'll throw that in:
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Davis and Ramsey, "Antiepileptic Action of Marijuana-Active
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Substances", Federation Proceedings 8 (1949): 284-285.
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[2 of 5 cases of severe anticonvulsant-resistant grand mal
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epilepsy controlled]
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Consroe, Wood, and Buchsbaum, "Anticonvulsant Nature of Marijuana
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Smoking", JAMA 234 (1975): 306-307.
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[case study: marijuana effective as adjunct to phenytoin and
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phenobarbital]
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Cunha, Carlini, Periera, et al., "Chronic Administration of
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Cannabidiol to Healthy Volunteers and Epileptic Patients",
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Pharmacology 21 (1980): 175-185.
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[cannabidiol effective as adjunct to antiepileptic drugs]
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The above cites are mostly from Grinspoon and Bakalar,
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_Marihuana, the Forbidden Medicine_. I've only read a few of the
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referenced articles, so I'm going by their commentary for the most
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part.
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>You can find such an example of this on the Shamen's album "Boss
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>Drum." The cut "Natural States" is an interview with someone bombed
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>out of their gourd, blabbering on and on about something which
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>probably makes complete sense to them, but is sheer nonsense to
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>anyone in full possession of thier senses.
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Would that be the Tim Leary track? :-)
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PGP 2 key by finger or e-mail
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Eli ebrandt@jarthur.claremont.edu
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