133 lines
4.0 KiB
Plaintext
133 lines
4.0 KiB
Plaintext
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(word processor parameters LM=8, RM=75, TM=2, BM=2)
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Taken from KeelyNet BBS (214) 324-3501
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Sponsored by Vangard Sciences
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PO BOX 1031
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Mesquite, TX 75150
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There are ABSOLUTELY NO RESTRICTIONS
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on duplicating, publishing or distributing the
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files on KeelyNet!
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December 29, 1990
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AGE5.ASC
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The Hayflick Limit
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In the early 60's, Dr. Leonard Hayflick carried out research at the
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Wistar Institute in Philadelphia which led to the discovery of the
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"Hayflick Limit".
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Hayflick found that lung tissue appeared to die out after the cells
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had divided a certain number of times (roughly 50). Cell cultures
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were also frozen after dividing 25 times. On revival, the cells
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would continue until the 50 division limit was reached, then die.
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As the cells approached the end of their division limit, the cells
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would take on the appearance of old tissue. This appearance
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included age pigments (lipofuscin) which is also found in aged
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hearts and brain cells.
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The discovery of the Hayflick Limit led to theories speculating on
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the existence of a cellular "clock". These clocks could be
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internally regulated for each individual cell (accounting for
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variations below and above the 50 limit) or controlled systemically
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by the hypothalamus of the brain.
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Another possibility is that control is exerted by the DNA since DNA
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is known to contain our genetic blueprints. Dr. James Fries and
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Dr. Lawrence Crapo write,
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"Probably, aging just happens, as the result of cumulative,
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random, and inevitable errors in translation of DNA into
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protein. The errors may even be a crucial part of a process
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that allows variation among individuals and thus allows
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natural selection."
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Mistakes in cell division tend to accumulate from the actions of
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viruses, free radicals, radiation and chemicals to affect the
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healthy replication of DNA. As the system ages and the DNA becomes
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more damaged, the DNA repair mechanism can no longer perform to its
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optimum level.
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Organisms and animals which have better DNA repair mechanisms tend
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to live longer than those who don't.
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One technique used by lower life forms is to minimize cell
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replication during daylight hours to prevent radiation damage from
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ionizing rays such as UV.
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Page 1
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Cell division is encouraged during the night to allow the best
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possible replication with a minimum of interfering radiation.
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--------------------------------------------------------------------
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If you have comments or other information relating to such topics
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as this paper covers, please upload to KeelyNet or send to the
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Vangard Sciences address as listed on the first page.
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Thank you for your consideration, interest and support.
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Jerry W. Decker.........Ron Barker...........Chuck Henderson
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Vangard Sciences/KeelyNet
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--------------------------------------------------------------------
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If we can be of service, you may contact
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Jerry at (214) 324-8741 or Ron at (214) 242-9346
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Page 2
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